Proliferative control in Drosophila stem cells.

Abstract:

:The relationship between cell growth (cell mass increase over time) and cell division is poorly understood in animal stem cells. Recent studies in several Drosophila stem cell types have provided the tools to interrogate this relationship. In several cases (brat, mei-P26, pros, bam, lethal giant larvae, polo), mutations have been defined that trigger tumorous overproliferation of progenitor cells and reveal how unrestricted self-renewing capacity is controlled. Moreover, microRNAs have been discovered as essential regulators of stem cell division rate and identity, suggesting that stem cell self-renewal depends on protein translational control. Biosynthetic capacity has also been found to be limiting for stem cell division rates. Finally, asymmetric cell division can impose dominant differentiation signals in a stem cell's daughter, and this can inhibit the stem cell-specific proliferation signature and lock in cell cycle exit.

journal_name

Curr Opin Cell Biol

authors

Kohlmaier A,Edgar BA

doi

10.1016/j.ceb.2008.10.002

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

699-706

issue

6

eissn

0955-0674

issn

1879-0410

pii

S0955-0674(08)00173-7

journal_volume

20

pub_type

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