Abstract:
:Spatiotemporal Ca2+ signalling in the cytoplasm is currently understood as an excitation phenomenon by analogy with electrical excitation in the plasma membrane. In many cell types, Ca2+ waves and Ca2+ oscillations are mediated by inositol 1,4,5-trisphosphate (IP3) receptor/Ca2+ channels in the endoplasmic reticulum membrane, with positive feedback between cytosolic Ca2+ and IP3-induced Ca2+ release creating a regenerative process. Remarkable advances have been made in the past year in the analysis of subcellular Ca2+ microdomains using confocal microscopy and of Ca2+ influx pathways that are functionally coupled to IP3-induced Ca2+ release. Ca2+ signals can be conveyed into the nucleus and mitochondria. Ca2+ entry from outside the cell allows repetitive Ca2+ release by providing Ca2+ to refill the endoplasmic reticulum stores, thus giving rise to frequency-encoded Ca2+ signals.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Miyazaki Sdoi
10.1016/0955-0674(95)80027-1subject
Has Abstractpub_date
1995-04-01 00:00:00pages
190-6issue
2eissn
0955-0674issn
1879-0410pii
0955-0674(95)80027-1journal_volume
7pub_type
杂志文章,评审abstract::The arrangement and dynamics of chromosomes inside the nucleus of mammalian cells have been studied intensively over the last two years. Although chromosomes are relatively immobile and occupy non-random positions in interphase, their dynamic movements in mitosis have traditionally been assumed to randomize this arran...
journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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