Abstract：
:Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail. The cilium is assembled from mature (mother) centrioles or basal bodies, which serve to nucleate growth of axonemes that give rise to two structurally distinct variants, motile and nonmotile cilia. Whereas motile cilia are typically found in large bundles and beat synchronously to generate fluid flow, primary cilia (with the exception of those found at the embryonic node) are generally immotile and are found as solitary organelles. Remarkably, until recently, the primary cilium was considered a vestigial organelle without apparent biological function. However, research over the past decade has established that the primary cilium is capable of transducing essential signaling information from the extracellular milieu. Defects in the cilium, and the structure from which it arises, the basal body, have been shown to cause a spectrum of diseases, ranging from developmental defects to obesity, diabetes, and cancer. Many of these diseases, or ciliopathies, are manifested as genetic syndromes, such as Joubert syndrome, Bardet-Biedel (BBS), Meckel-Gruber (MKS), and Nephronophthisis (NPHP), illustrating the importance of understanding cilium structure and function and the mechanisms required for its assembly. This review focuses primarily on recent advances in our understanding of the regulatory controls governing the assembly and maintenance of the primary cilium.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Kim S,Dynlacht BDdoi
10.1016/j.ceb.2013.04.011subject
Has Abstractpub_date
2013-08-01 00:00:00pages
506-11issue
4eissn
0955-0674issn
1879-0410pii
S0955-0674(13)00074-4journal_volume
25pub_type
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：1992-04-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章
doi：10.1016/s0955-0674(96)80054-8
更新日期：1996-02-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：1996-02-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2017.02.002
更新日期：2017-08-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：2002-04-01 00:00:00
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journal_title：Current opinion in cell biology
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更新日期：2015-12-01 00:00:00
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journal_title：Current opinion in cell biology
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更新日期：2014-08-01 00:00:00
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
