Abstract:
:Protein degradation plays key roles in diverse pathways in cell division, growth and differentiation. Aberrant stabilization of crucial proteins participating in oncogenic pathways is often observed in cancer. The importance of proper protein turnover is exemplified by the SCF(Fbxw7) ubiquitin ligase, which is frequently mutated in human cancer, including T cell acute lymphoblastic leukemia. Recent studies have revealed novel substrates of Fbxw7 and shed light on its role on differentiation of stem cells and expansion of stem-cell-like cells driving tumorigenesis. Detailed understanding of the contribution of the Fbxw7-regulated network of proteins in initiation and progression of cancer will facilitate the identification of candidate intervention targets in human cancer.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Kourtis N,Strikoudis A,Aifantis Idoi
10.1016/j.ceb.2015.09.003subject
Has Abstractpub_date
2015-12-01 00:00:00pages
28-34eissn
0955-0674issn
1879-0410pii
S0955-0674(15)00113-1journal_volume
37pub_type
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