Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives.

abstract：:Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals. During the past year, numerous candidate downstream targets for these GTPases have been identified using affinity chromatography and yeast two-hybrid t...

journal_title：Current opinion in cell biology

authors： Tapon N,Hall A

更新日期：1997-02-01 00:00:00

abstract：:The proposition is forwarded that the cAMP-dependent protein kinase is one of quite a small class of enzymes wherein differential modes of binding of its multiple substrates make an important contribution to the end physiological response. It is postulated that a variety of different substrate affinities may have evol...

journal_title：Current opinion in cell biology

authors： Walsh DA,Glass DB,Mitchell RD

更新日期：1992-04-01 00:00:00

abstract：:Recent evidence corroborates the idea that the structure of the nucleolus need not be strictly maintained for proper function, suggesting that the organelle is composed of supramolecular assemblies formed during rRNA synthesis. More controversial is whether the nucleolus exists in the absence of rRNA synthesis and whe...

journal_title：Current opinion in cell biology

authors： Mélèse T,Xue Z

更新日期：1995-06-01 00:00:00

abstract：:Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functi...

journal_title：Current opinion in cell biology

authors： Will CL,Lührmann R

更新日期：1997-06-01 00:00:00

abstract：:In the past year, major advances have been made in our understanding of the regulation of phosphoinositidase C, and of the action of the inositol trisphosphate receptor and how it may generate 'quantal' Ca2+ release. The functions of inositol tetrakisphosphate and of the 3-phosphorylated inositol lipids continue to ge...

journal_title：Current opinion in cell biology

authors： Irvine RF

更新日期：1992-04-01 00:00:00

abstract：:In vitro experiments led to a simple model in which basal transcription factors sequentially assembled with RNA Polymerase II to generate a preinitiation complex (PIC). Emerging evidence indicates that PIC composition is not universal, but promoter-dependent. Active promoters are occupied by a mixed population of comp...

journal_title：Current opinion in cell biology

authors： Sikorski TW,Buratowski S

更新日期：2009-06-01 00:00:00

abstract：:The spatial separation of nuclear transcription and cytoplasmic translation in eukaryotic cells implies that mRNAs have to travel. On their journey, proteins involved in the various steps of transcript formation, processing and transport dynamically interact with mRNAs to form diverse messenger ribonucleoprotein compl...

journal_title：Current opinion in cell biology

authors： Sommer P,Nehrbass U

更新日期：2005-06-01 00:00:00

abstract：:Most cancers arise in epithelia, the tissue type that lines all body cavities. The organization of epithelia enables them to act as a barrier and perform vectorial transport of molecules between body compartments. Crucial for their organization and function is a highly specialized network of cell adhesion and polarity...

journal_title：Current opinion in cell biology

authors： Hinck L,Näthke I

更新日期：2014-02-01 00:00:00

abstract：:The number and variety of factors underlying control of gene expression have been frequently underestimated. Non-coding RNAs generated through pervasive transcription have recently been implicated in shaping the transcriptional landscape in different organisms from bacteria to higher eukaryotes, adding a previously un...

journal_title：Current opinion in cell biology

authors： Castelnuovo M,Stutz F

更新日期：2015-06-01 00:00:00

abstract：:Spatiotemporal Ca2+ signalling in the cytoplasm is currently understood as an excitation phenomenon by analogy with electrical excitation in the plasma membrane. In many cell types, Ca2+ waves and Ca2+ oscillations are mediated by inositol 1,4,5-trisphosphate (IP3) receptor/Ca2+ channels in the endoplasmic reticulum m...

journal_title：Current opinion in cell biology

authors： Miyazaki S

更新日期：1995-04-01 00:00:00

abstract：:In Caenorhabditis elegans, cell migration is guided by localized cues, including molecules such as EGL-17/FGF and UNC-6/netrin. These external cues are linked to an intracellular response to migrate, at least in part, by CED-5, a homolog of DOCK180/MBC, and MIG-2, a Rac-like GTPase. In addition, metalloproteases are r...

journal_title：Current opinion in cell biology

authors： Blelloch R,Newman C,Kimble J

更新日期：1999-10-01 00:00:00

abstract：:The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings...

journal_title：Current opinion in cell biology

authors： Phua SC,Nihongaki Y,Inoue T

更新日期：2018-02-01 00:00:00

abstract：:The mitotic spindle assembly and chromosome segregation in eukaryotes must be coordinated with the nuclear envelope (NE) remodeling. In a so-called 'open' mitosis the envelope of the mother nucleus is dismantled allowing the cytoplasmic spindle microtubules to capture the chromosomes. Alternatively, cells undergoing '...

journal_title：Current opinion in cell biology

authors： Zhang D,Oliferenko S

更新日期：2013-02-01 00:00:00

abstract：:The mitotic and meiotic cell cycle share many regulators, but there are also important differences between the two processes. The meiotic maturation of Xenopus oocytes has proved useful for understanding the regulation of Cdc2-cyclin-B, a key activator of G2/M progression. New insights have been made recently into the...

journal_title：Current opinion in cell biology

authors： Nebreda AR,Ferby I

更新日期：2000-12-01 00:00:00

abstract：:The principal subunits of a large superfamily of plasma-membrane cation channels are functionally autonomous in ion conductance and in gating by membrane potential and intracellular ligands. Recent work has located the structural elements responsible for the ion conductance and gating of these channels. These studies ...

journal_title：Current opinion in cell biology

authors： Catterall WA

更新日期：1994-08-01 00:00:00

abstract：:The concept that ostensibly tissue-specific stem cells can give rise to cells of heterologous lineages has gained support from studies using purified hematopoietic stem cells and sensitive donor-cell tracking methods. The ability to exploit these findings in clinical settings will probably depend on new insights into ...

journal_title：Current opinion in cell biology

authors： Goodell MA

更新日期：2001-12-01 00:00:00

abstract：:Focal adhesion kinase (pp125FAK), a protein tyrosine kinase, has recently been suggested to regulate aspects of signalling induced by integrins and by certain growth factor and hormone receptors. New studies indicate that the domains of pp125FAK regulate its interactions with integrin subunits, other protein tyrosine ...

journal_title：Current opinion in cell biology

authors： Schaller MD,Parsons JT

更新日期：1994-10-01 00:00:00

abstract：:Regulation of messenger RNA (mRNA) transcription, processing and translation occurs in the context of biomolecular condensates. How the physical properties of condensates connect with their biological regulatory functions is an ongoing area of interest, particularly for RNA metabolic pathways. Phosphorylation has emer...

journal_title：Current opinion in cell biology

authors： Nosella ML,Forman-Kay JD

更新日期：2021-01-12 00:00:00

abstract：:This past year has seen a significant increase in our understanding of eukaryotic origins of replication, of the proteins that identify these origins, of DNA sequences that promote their unwinding, and of transcription factors that stimulate origin activity. DNA replication begins at specific sites in both simple and ...

journal_title：Current opinion in cell biology

authors： DePamphilis ML

更新日期：1993-06-01 00:00:00

abstract：:One parental copy of an imprinted gene is invariably expressed during development. The characteristic of the heritable epigenetic germline imprint remains elusive, but recent evidence stresses the necessity for additional post-zygotic epigenetic modifications to account for this temporal and tissue-specific mono-allel...

journal_title：Current opinion in cell biology

authors： Surani MA

更新日期：1994-06-01 00:00:00

abstract：:Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic network that through interactions with all vital cell structures, provides an effective mechanochemical integrator of morphology and function, absolutely necessary for intra-cellular and intercellular coordination of all muscle fun...

journal_title：Current opinion in cell biology

authors： Capetanaki Y,Papathanasiou S,Diokmetzidou A,Vatsellas G,Tsikitis M

更新日期：2015-02-01 00:00:00

abstract：:Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by GEFs (guanine nucleotide exchange factors) and then inactivated by GAPs (GTPase activating proteins). Recent evidence shows that in addition to activati...

journal_title：Current opinion in cell biology

authors： Lamber EP,Siedenburg AC,Barr FA

更新日期：2019-08-01 00:00:00

abstract：:Diverse post-translational modifications of histone amino termini represent an important epigenetic mechanism for the organisation of chromatin structure and the regulation of gene activity. Within the past two years, great progress has been made in understanding the functional implications of histone methylation; in ...

journal_title：Current opinion in cell biology

authors： Lachner M,Jenuwein T

更新日期：2002-06-01 00:00:00

abstract：:A nuclear pore complex (NPC) is a large protein assembly that mediates the nucleocytoplasmic exchange of molecules. During the cell cycle, NPCs assemble, disassemble, and dynamically change their distribution on assembled nuclear envelope (NE), whereas in post-mitosis, NPCs are extremely stable. Extensive studies on i...

journal_title：Current opinion in cell biology

authors： Imamoto N,Funakoshi T

更新日期：2012-08-01 00:00:00

abstract：:A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity toward relevant substrates. Recently the structural basis for these protein-protein interactions has ...

journal_title：Current opinion in cell biology

authors： Beene DL,Scott JD

更新日期：2007-04-01 00:00:00

abstract：:In the past decade, studies into the way in which intracellular bacterial pathogens hijack and subvert their hosts have provided many important insights into regulation of the actin cytoskeleton and cell motility, in addition to increasing our understanding of the infection process. Viral pathogens, however, may ultim...

journal_title：Current opinion in cell biology

authors： Ploubidou A,Way M

更新日期：2001-02-01 00:00:00

abstract：:Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and membranes. Innate immune cells and transformed cancer cells share the capacity for both constitutive and induced macropinocytosis, which...

journal_title：Current opinion in cell biology

authors： Stow JL,Hung Y,Wall AA

更新日期：2020-08-01 00:00:00

abstract：:The development of a complex multicellular organism requires a coordination of growth and cell division under the control of patterning mechanisms. Studies in yeast have pioneered our understanding of the relationship between growth and cell division. In recent years, many of the pathways that regulate growth in multi...

journal_title：Current opinion in cell biology

authors： Tapon N,Moberg KH,Hariharan IK

更新日期：2001-12-01 00:00:00

abstract：:The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place th...

journal_title：Current opinion in cell biology

authors： Yonemura S

更新日期：2011-10-01 00:00:00

abstract：:Polarity is defined by the segregation of cellular components along a defined axis. To polarize robustly, cells must be able to break symmetry and subsequently amplify these nascent asymmetries. Finally, asymmetric localization of signaling molecules must be translated into functional regulation of downstream effector...

journal_title：Current opinion in cell biology

authors： Peglion F,Goehring NW

更新日期：2019-10-01 00:00:00