Rab regulation by GEFs and GAPs during membrane traffic.

Abstract:

:Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by GEFs (guanine nucleotide exchange factors) and then inactivated by GAPs (GTPase activating proteins). Recent evidence shows that in addition to activating and inactivating Rab GTPases, both Rab GEFs and GAPs directly contribute to membrane tethering events during vesicle traffic. Other studies have extended the range of processes, in which Rabs function, and revealed roles for Rabs and their GAPs in the regulation of autophagy. Here, we will discuss these advances and the emerging relationship between the domain architectures of Rab GEFs and vesicle coat protein complexes linked with GTPases of the Sar, ARF and Arl families in animal cells.

journal_name

Curr Opin Cell Biol

authors

Lamber EP,Siedenburg AC,Barr FA

doi

10.1016/j.ceb.2019.03.004

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

34-39

eissn

0955-0674

issn

1879-0410

pii

S0955-0674(19)30003-1

journal_volume

59

pub_type

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