Abstract:
:Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by GEFs (guanine nucleotide exchange factors) and then inactivated by GAPs (GTPase activating proteins). Recent evidence shows that in addition to activating and inactivating Rab GTPases, both Rab GEFs and GAPs directly contribute to membrane tethering events during vesicle traffic. Other studies have extended the range of processes, in which Rabs function, and revealed roles for Rabs and their GAPs in the regulation of autophagy. Here, we will discuss these advances and the emerging relationship between the domain architectures of Rab GEFs and vesicle coat protein complexes linked with GTPases of the Sar, ARF and Arl families in animal cells.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Lamber EP,Siedenburg AC,Barr FAdoi
10.1016/j.ceb.2019.03.004subject
Has Abstractpub_date
2019-08-01 00:00:00pages
34-39eissn
0955-0674issn
1879-0410pii
S0955-0674(19)30003-1journal_volume
59pub_type
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