Abstract：
:The mitotic spindle assembly and chromosome segregation in eukaryotes must be coordinated with the nuclear envelope (NE) remodeling. In a so-called 'open' mitosis the envelope of the mother nucleus is dismantled allowing the cytoplasmic spindle microtubules to capture the chromosomes. Alternatively, cells undergoing 'closed' mitosis assemble the intranuclear spindle and divide the nucleus without ever losing the nucleocytoplasmic compartmentalization. Here we focus on the mechanisms underlying mitotic NE dynamics in unicellular eukaryotes undergoing a closed nuclear division, paying specific attention to the emerging roles of the lipid biosynthesis machinery in this process. We argue that lessons learned in these organisms may be generally relevant to understanding the NE remodeling and the evolution of mitotic mechanisms throughout the eukaryotic domain.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Zhang D,Oliferenko Sdoi
10.1016/j.ceb.2012.09.001subject
Has Abstractpub_date
2013-02-01 00:00:00pages
142-8issue
1eissn
0955-0674issn
1879-0410pii
S0955-0674(12)00140-8journal_volume
25pub_type
杂志文章,评审abstract：:Several aspects of the interactions between growth factors and cell adhesion are described. Recent advances in the field come from the identification of molecules resembling growth factors or growth factor receptors, which bear cell adhesion motifs as well as molecules participating in both cell growth control and adh...
journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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