Control of cell migration during Caenorhabditis elegans development.

abstract：:A hallmark of polarity in most migrating cells is the orientation of the nuclear centrosomal (NC) axis relative to the front-back cellular axis. Here, we review 'effector functions' associated with the NC axis during cell migration. We highlight recent research that has demonstrated that the orientation of the NC axis...

journal_title：Current opinion in cell biology

authors： Luxton GW,Gundersen GG

更新日期：2011-10-01 00:00:00

abstract：:Most cancers arise in epithelia, the tissue type that lines all body cavities. The organization of epithelia enables them to act as a barrier and perform vectorial transport of molecules between body compartments. Crucial for their organization and function is a highly specialized network of cell adhesion and polarity...

journal_title：Current opinion in cell biology

authors： Hinck L,Näthke I

更新日期：2014-02-01 00:00:00

abstract：:Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by GEFs (guanine nucleotide exchange factors) and then inactivated by GAPs (GTPase activating proteins). Recent evidence shows that in addition to activati...

journal_title：Current opinion in cell biology

authors： Lamber EP,Siedenburg AC,Barr FA

更新日期：2019-08-01 00:00:00

abstract：:Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic...

journal_title：Current opinion in cell biology

authors： Burke B

更新日期：2018-06-01 00:00:00

abstract：:Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold o...

journal_title：Current opinion in cell biology

authors： Fernandez-Martinez J,Rout MP

更新日期：2009-08-01 00:00:00

abstract：:In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single cell level have revealed that transcriptional kinetics are high...

journal_title：Current opinion in cell biology

authors： Suter DM,Molina N,Naef F,Schibler U

更新日期：2011-12-01 00:00:00

abstract：:Protection from cancer and ensured longevity are tightly linked in mammals. One of the fundamental mechanisms contributing to both is the cellular response to DNA damage. The appropriate response is an initial attempt at repair, but if the damage is too extensive or compromises DNA metabolism, a signalling cascade tri...

journal_title：Current opinion in cell biology

authors： Mitchell JR,Hoeijmakers JH,Niedernhofer LJ

更新日期：2003-04-01 00:00:00

abstract：:The shaping of the vertebrate embryonic body plan depends heavily on the narrowing and lengthening (convergence and extension) of embryonic tissues by cell intercalation, a process by which cells actively crawl between one another along the axis of convergence to produce a narrower, longer array. We discuss recent evi...

journal_title：Current opinion in cell biology

authors： Skoglund P,Keller R

更新日期：2010-10-01 00:00:00

abstract：:Polarising a cell or an embryo is a crucial and recurrent event during development, as it is important for cell differentiation and migration. Cells can become polarised along their apical-basal axis and also within the plane of the tissue layer to which they belong. The embryo develops three axes: the anteroposterior...

journal_title：Current opinion in cell biology

authors： Wedlich D

更新日期：2002-10-01 00:00:00

abstract：:Tight junctions create a paracellular barrier between both epithelial and endothelial cells. Recent advances have helped define their molecular composition and regulation. Studies in cultured cell lines provide new insights into how assembly and barrier properties may be controlled by signal transduction cascades. ...

journal_title：Current opinion in cell biology

authors： Anderson JM,Balda MS,Fanning AS

更新日期：1993-10-01 00:00:00

abstract：:Cell polarization is critical for lineage segregation and morphogenesis during mammalian embryogenesis. However, the processes and mechanisms that establish cell polarity in the mammalian embryo are not well understood. Recent studies suggest that unique regulatory mechanisms are deployed by the mouse embryo to establ...

journal_title：Current opinion in cell biology

authors： Zhu M,Zernicka-Goetz M

更新日期：2020-02-01 00:00:00

abstract：:The Polycomb group proteins are best known for their role as epigenetic regulators of the fly homeotic (Hox) gene clusters, but it has long been clear that these well conserved proteins have many other targets. For example, they are vital for maintaining both the pluripotency of stem cells and the identity of differen...

journal_title：Current opinion in cell biology

authors： Ringrose L

更新日期：2007-06-01 00:00:00

abstract：:New structural analyses of the spectrin family of actin cross-linking proteins are providing molecular explanations for both the interchain binding between the alpha and beta chains of spectrin and the intermolecular associations between spectrin and other proteins. Additionally, the analyses bring into focus a confor...

journal_title：Current opinion in cell biology

authors： Viel A,Branton D

更新日期：1996-02-01 00:00:00

abstract：:Misfolded and mistargeted proteins in the early secretory pathway present significant risks to the cell. A diverse and integrated network of quality control pathways protects the cell from these threats. We focus on the discovery of new mechanisms that contribute to this protective network. Biochemical and structural ...

journal_title：Current opinion in cell biology

authors： Phillips BP,Gomez-Navarro N,Miller EA

更新日期：2020-08-01 00:00:00

abstract：:In the adult, angiogenesis, the formation of new blood vessels from pre-existing vasculature contributes to the pathogenesis of many disorders including cancer. The role of adhesion molecules, especially integrins, in pathological angiogenesis has long been the subject of investigation, mostly because of their potenti...

journal_title：Current opinion in cell biology

authors： Hodivala-Dilke K

更新日期：2008-10-01 00:00:00

abstract：:As a 'double-edged sword', neutrophil (polymorphonuclear leukocyte) migration across epithelial-lined organs is an important component of host defense, but it also results in epithelial pathophysiology and disease symptoms. There have been significant advances in better understanding the mechanisms of how leukocytes c...

journal_title：Current opinion in cell biology

authors： Zen K,Parkos CA

更新日期：2003-10-01 00:00:00

abstract：:A consensus view on the three-dimensional structure of the F-actin filament and the relative strength of the intersubunit contacts in the filament has been established from an atomic filament model and recent three-dimensional reconstructions from electron micrographs of F-actin filaments. Functional implications of r...

journal_title：Current opinion in cell biology

authors： Bremer A,Aebi U

更新日期：1992-02-01 00:00:00

abstract：:Signaling involves the coordinated action of multiple molecules including stimuli, receptors and enzymes part of which interact with the transcriptional machinery and target chromatin. Signaling systems regulate the cell events responsible for survival, development and homeostasis. Many of the signaling pathways induc...

journal_title：Current opinion in cell biology

authors： Suganuma T,Workman JL

更新日期：2013-06-01 00:00:00

abstract：:The concept that ostensibly tissue-specific stem cells can give rise to cells of heterologous lineages has gained support from studies using purified hematopoietic stem cells and sensitive donor-cell tracking methods. The ability to exploit these findings in clinical settings will probably depend on new insights into ...

journal_title：Current opinion in cell biology

authors： Goodell MA

更新日期：2001-12-01 00:00:00

abstract：:Evolution of the mammalian sex chromosomes heavily impacts on the expression of X-encoded genes, both in marsupials and placental mammals. The loss of genes from the Y chromosome forced a two-fold upregulation of dose sensitive X-linked homologues. As a corollary, female cells would experience a lethal dose of X-linke...

journal_title：Current opinion in cell biology

authors： Gribnau J,Grootegoed JA

更新日期：2012-06-01 00:00:00

abstract：:The actin supergene family encodes a number of structurally related, but perhaps functionally distinct, protein isoforms that regulate contractile potential in muscle tissues and help to control the shape as well as the motility of non-muscle cells. In spite of the documented conservation amongst isoactin genes and th...

journal_title：Current opinion in cell biology

authors： Herman IM

更新日期：1993-02-01 00:00:00

abstract：:Plant cells are connected across cell walls by nanoscopic channels called plasmodesmata (PD), which allow plant cells to share resources and exchange signaling molecules. Several protein components of PD membranes have been identified, and recent advances in superresolution live-cell microscopy are illuminating PD ult...

journal_title：Current opinion in cell biology

authors： Brunkard JO,Runkel AM,Zambryski PC

更新日期：2015-08-01 00:00:00

abstract：:Cell surface molecules, ligands, and solutes can be endocytosed into animal cells via several pathways in addition to clathrin-mediated endocytosis, which all seem to lead to canonical endosomes. It seems that viruses can enter and infect cells through most of, if not all, endocytic routes, having evolved different, s...

journal_title：Current opinion in cell biology

authors： Gruenberg J

更新日期：2009-08-01 00:00:00

abstract：:Myosins are a large family of structurally diverse mechanoenzymes which, upon interaction with actin filaments, convert energy from ATP hydrolysis into mechanical force. Consistent with the ubiquitous association of actin with membranes, many of these novel myosins are membrane-associated. In the past two years, evide...

journal_title：Current opinion in cell biology

authors： Hasson T,Mooseker MS

更新日期：1995-08-01 00:00:00

abstract：:Regulation of messenger RNA (mRNA) transcription, processing and translation occurs in the context of biomolecular condensates. How the physical properties of condensates connect with their biological regulatory functions is an ongoing area of interest, particularly for RNA metabolic pathways. Phosphorylation has emer...

journal_title：Current opinion in cell biology

authors： Nosella ML,Forman-Kay JD

更新日期：2021-01-12 00:00:00

abstract：:The cell biologist's insight into endosomal diversity, in terms of both form and function, has increased dramatically in the past few years. This understanding has been promoted by the availability of powerful new techniques that allow imaging of both cargo and machinery in the endocytic process in real time, and by o...

journal_title：Current opinion in cell biology

authors： Perret E,Lakkaraju A,Deborde S,Schreiner R,Rodriguez-Boulan E

更新日期：2005-08-01 00:00:00

abstract：:The processes of dying are as tightly regulated as those of growth and proliferation, and together they establish a finely tuned balance that ensures proper organ size and function. Failure in the regulation of these responses lies at the heart of many human diseases. Certain members of the inhibitor of apoptosis (IAP...

journal_title：Current opinion in cell biology

authors： Lopez J,Meier P

更新日期：2010-12-01 00:00:00

abstract：:Blood vessel development is a vital process during embryonic development, during tissue growth, regeneration and disease processes in the adult. In the past decade researchers have begun to unravel basic molecular mechanisms that regulate the formation of vascular lumen, sprouting angiogenesis, fusion of vessels, and ...

journal_title：Current opinion in cell biology

authors： Wacker A,Gerhardt H

更新日期：2011-12-01 00:00:00

abstract：:Intracellular signals are received and generated by the alpha(IIb)beta(3) integrin on platelets. Recent advances have been made in the areas of agonist receptors that initiate platelet activation, downstream signaling molecules (e.g. small G-proteins and kinases) and changes in ligand-occupied alpha(IIb)beta(3) that c...

journal_title：Current opinion in cell biology

authors： Parise LV

更新日期：1999-10-01 00:00:00

abstract：:Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals. During the past year, numerous candidate downstream targets for these GTPases have been identified using affinity chromatography and yeast two-hybrid t...

journal_title：Current opinion in cell biology

authors： Tapon N,Hall A

更新日期：1997-02-01 00:00:00