Abstract：
:The cell biologist's insight into endosomal diversity, in terms of both form and function, has increased dramatically in the past few years. This understanding has been promoted by the availability of powerful new techniques that allow imaging of both cargo and machinery in the endocytic process in real time, and by our ability to inhibit components of this machinery by RNA interference. The emerging picture from these studies is of a highly complex, dynamic and adaptable endosomal system that interacts at various points with the secretory system of the cell.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Perret E,Lakkaraju A,Deborde S,Schreiner R,Rodriguez-Boulan Edoi
10.1016/j.ceb.2005.06.008subject
Has Abstractpub_date
2005-08-01 00:00:00pages
423-34issue
4eissn
0955-0674issn
1879-0410pii
S0955-0674(05)00089-Xjournal_volume
17pub_type
杂志文章,评审abstract：:Like other spectrin repeat proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton. However nuclear envelope (NE) nesprins, uniquely hardwire the nuclear lamina to the cytoskeleton and molecular motors. Emerging evidence suggests that nesprins also form a ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2010.11.006
更新日期：2011-02-01 00:00:00
abstract：:In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single cell level have revealed that transcriptional kinetics are high...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2011.09.004
更新日期：2011-12-01 00:00:00
abstract：:The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2010.08.021
更新日期：2010-12-01 00:00:00
abstract：:Flowers and shoots are derived from specialized groups of stem cells termed meristems. Recent studies in Arabidopsis have identified factors that contribute to meristem structure and identity, such as CLAVATA1, CLAVATA3, and SHOOTMERISTEMLESS, which act in both shoot and flower meristems, as well as LEAFY and APETALA1...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(96)80089-5
更新日期：1996-12-01 00:00:00
abstract：:Integrins have the ability to organise macromolecular structures both inside and outside the cell. Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word. ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00142-3
更新日期：2000-10-01 00:00:00
abstract：:Tissue stem cells are found in specialized microenvironments (niches) where they are exposed to diverse systemic and local signals that are integrated with cell intrinsic factors to regulate stem cell behavior. In general, systemic signals are utilized to coordinate the response of tissues to acute or long-term change...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2012.01.004
更新日期：2012-04-01 00:00:00
abstract：:When PI3Ks are deregulated by aberrant surface receptors or modulators, accumulation of PtdIns(3,4,5)P3 leads to increased cell growth, proliferation and contact-independent survival. The PI3K/PKB/TOR axis controls protein synthesis and growth, while PtdIns(3,4,5)P3-mediated activation of Rho GTPases directs cell moti...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2005.02.011
更新日期：2005-04-01 00:00:00
abstract：:The relationship between cell growth (cell mass increase over time) and cell division is poorly understood in animal stem cells. Recent studies in several Drosophila stem cell types have provided the tools to interrogate this relationship. In several cases (brat, mei-P26, pros, bam, lethal giant larvae, polo), mutatio...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2008.10.002
更新日期：2008-12-01 00:00:00
abstract：:Primordial germ cells (PGCs), the progenitors of the gametes, migrate from the position where they are specified towards the region where the gonad develops. To reach their target, the PGCs obtain directional cues from cells positioned along their migration path. One such cue, the chemokine SDF-1, has recently been fo...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2004.01.004
更新日期：2004-04-01 00:00:00
abstract：:Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau pro...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00194-0
更新日期：2001-04-01 00:00:00
abstract：:Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail. The cilium is assembled from mature (mother) centr...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.04.011
更新日期：2013-08-01 00:00:00
abstract：:One parental copy of an imprinted gene is invariably expressed during development. The characteristic of the heritable epigenetic germline imprint remains elusive, but recent evidence stresses the necessity for additional post-zygotic epigenetic modifications to account for this temporal and tissue-specific mono-allel...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(94)90031-0
更新日期：1994-06-01 00:00:00
abstract：:Regulation of messenger RNA (mRNA) transcription, processing and translation occurs in the context of biomolecular condensates. How the physical properties of condensates connect with their biological regulatory functions is an ongoing area of interest, particularly for RNA metabolic pathways. Phosphorylation has emer...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.12.007
更新日期：2021-01-12 00:00:00
abstract：:Positive-strand RNA (+RNA) viruses (e.g. poliovirus, hepatitis C virus, dengue virus, SARS-coronavirus) remodel cellular membranes to form so-called viral replication compartments (VRCs), which are the sites where viral RNA genome replication takes place. To induce VRC formation, these viruses extensively rewire lipid...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2017.02.005
更新日期：2017-08-01 00:00:00
abstract：:Secretion of proteins across the bacterial outer membrane takes place via a variety of mechanisms from simple one-component systems to complex multicomponent pathways. Secretion pathways can be organized into evolutionarily and functionally related groups, which highlight their relationship with organelle biogenesis. ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00111-3
更新日期：2000-08-01 00:00:00
abstract：:Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown that PcG mechanisms control a large number of genes regulating many cellular functions and all developmental pathways. Cur...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2008.03.002
更新日期：2008-06-01 00:00:00
abstract：:Far from being simple 'bags' of enzymes, bacteria are richly endowed with ultrastructures that challenge and expand standard definitions of the cytoskeleton. Here we review rods, rings, twisted pairs, tubes, sheets, spirals, moving patches, meshes and composites, and suggest defining the term 'bacterial cytoskeleton' ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2012.10.019
更新日期：2013-02-01 00:00:00
abstract：:New structural analyses of the spectrin family of actin cross-linking proteins are providing molecular explanations for both the interchain binding between the alpha and beta chains of spectrin and the intermolecular associations between spectrin and other proteins. Additionally, the analyses bring into focus a confor...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(96)80048-2
更新日期：1996-02-01 00:00:00
abstract：:The insulin receptor substrates function at the heart of the insulin signalling network. It has recently become apparent that the intracellular localisation of these molecules is regulated in a precise manner that is critical for both the generation and the termination of the insulin signal. Some insulin receptor subs...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(99)00079-4
更新日期：2000-04-01 00:00:00
abstract：:The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depe...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.06.004
更新日期：2013-10-01 00:00:00
abstract：:The hetero-hexameric origin recognition complex (ORC) is well known for its separable roles in DNA replication and heterochromatin assembly. However, ORC and its individual subunits have been implicated in diverse cellular activities in both the nucleus and the cytoplasm. Some of ORC's implied functions, such as cell ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2007.04.007
更新日期：2007-06-01 00:00:00
abstract：:Emerging studies indicate that connexins have activities completely unrelated to gap junctions and, conversely, that non-connexin proteins can form gap junction channels. ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2004.07.014
更新日期：2004-10-01 00:00:00
abstract：:Actin polymerization generates the force that deforms the cell membrane, pulls the cell forward and propels endosomes and bacteria within the cell. The mechanism of force generation has been probed using experimental biomimetic systems where force generation and movement occur by the same actin-polymerization processe...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2004.12.001
更新日期：2005-02-01 00:00:00
abstract：:Several lines of evidence indicate that the lipids in the plasma membrane of animal cells are inhomogeneously distributed, and that various types of specialized lipid domains play an important role in many biological processes. The characteristics of these domains, such as size, composition and dynamics, are currently...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(02)00351-4
更新日期：2002-08-01 00:00:00
abstract：:Inability to meet protein folding demands within the endoplasmic reticulum (ER) activates the unfolded protein response (UPR), a signaling pathway with both adaptive and apoptotic outputs. While some secretory cell types have a remarkable ability to increase protein folding capacity, their upper limits can be reached ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2010.11.003
更新日期：2011-04-01 00:00:00
abstract：:Research into the molecular mechanisms of target cell recognition by natural killer (NK) cells has recently progressed rapidly. NK cells express several MHC I recognizing receptors that inactivate the NK cells' functions. In pathological alterations of MHC I expression, the NK cell inhibitory receptors do not engage a...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(97)80120-2
更新日期：1997-10-01 00:00:00
abstract：:Dystroglycan provides a crucial linkage between the cytoskeleton and the basement membrane for skeletal muscle cells. Disruption of this linkage leads to various forms of muscular dystrophy. Significant recent advances in understanding the structure and function of dystroglycan include detailed in vitro and in vivo an...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(96)80103-7
更新日期：1996-10-01 00:00:00
abstract：:A hallmark of polarity in most migrating cells is the orientation of the nuclear centrosomal (NC) axis relative to the front-back cellular axis. Here, we review 'effector functions' associated with the NC axis during cell migration. We highlight recent research that has demonstrated that the orientation of the NC axis...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2011.08.001
更新日期：2011-10-01 00:00:00
abstract：:The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are un...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/S0955-0674(99)80050-7
更新日期：1999-06-01 00:00:00
abstract：:Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain their size without...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2016.02.004
更新日期：2016-02-01 00:00:00
