Polycomb complexes and epigenetic states.

abstract：:Emerging studies indicate that connexins have activities completely unrelated to gap junctions and, conversely, that non-connexin proteins can form gap junction channels. ...

journal_title：Current opinion in cell biology

authors： Stout C,Goodenough DA,Paul DL

更新日期：2004-10-01 00:00:00

abstract：:The Polycomb group proteins are best known for their role as epigenetic regulators of the fly homeotic (Hox) gene clusters, but it has long been clear that these well conserved proteins have many other targets. For example, they are vital for maintaining both the pluripotency of stem cells and the identity of differen...

journal_title：Current opinion in cell biology

authors： Ringrose L

更新日期：2007-06-01 00:00:00

abstract：:A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of...

journal_title：Current opinion in cell biology

authors： Gruenberg J,Clague MJ

更新日期：1992-08-01 00:00:00

abstract：:A major current issue in vesicle trafficking is whether NSF (N-ethylmaleimide-sensitive factor) and alpha-SNAP (alpha-soluble NSF attachment protein) are required prior to SNARE (SNAP receptor) complex formation to allow vesicle docking, or after docking at a step close to membrane fusion. Recent studies of yeast vacu...

journal_title：Current opinion in cell biology

authors： Hay JC,Scheller RH

更新日期：1997-08-01 00:00:00

abstract：:Cohesin is a four subunit complex, conserved from yeast to man, with the ability to hold together two DNA segments within its ring-shaped structure. When the two segments belong to sister chromatids, cohesin is mediating cohesion, which is essential for chromosome segregation in mitosis and meiosis and for homologous ...

journal_title：Current opinion in cell biology

authors： Remeseiro S,Losada A

更新日期：2013-02-01 00:00:00

abstract：:Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals. During the past year, numerous candidate downstream targets for these GTPases have been identified using affinity chromatography and yeast two-hybrid t...

journal_title：Current opinion in cell biology

authors： Tapon N,Hall A

更新日期：1997-02-01 00:00:00

abstract：:Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen g...

journal_title：Current opinion in cell biology

authors： Cukierman E,Pankov R,Yamada KM

更新日期：2002-10-01 00:00:00

abstract：:HOM/Hox genes are master regulatory switches that specify axial identity and control the growth and differentiation of groups of cells related by position. HOM/Hox genes function combinatorially and hierarchically to specify cell fate. Some of the genes they regulate and that mediate specific identify functions have b...

journal_title：Current opinion in cell biology

authors： Botas J

更新日期：1993-12-01 00:00:00

abstract：:Clathrin-mediated endocytosis (CME) is the main endocytic pathway supporting housekeeping functions in cells. However, CME may be too slow to internalize proteins from the cell surface during certain physiological processes such as reaction to stress hormones ('fight-or-flight' reaction), chemotaxis or compensatory en...

journal_title：Current opinion in cell biology

authors： Watanabe S,Boucrot E

更新日期：2017-08-01 00:00:00

abstract：:Myosins are a large family of structurally diverse mechanoenzymes which, upon interaction with actin filaments, convert energy from ATP hydrolysis into mechanical force. Consistent with the ubiquitous association of actin with membranes, many of these novel myosins are membrane-associated. In the past two years, evide...

journal_title：Current opinion in cell biology

authors： Hasson T,Mooseker MS

更新日期：1995-08-01 00:00:00

abstract：:Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain their size without...

journal_title：Current opinion in cell biology

authors： Sauls JT,Li D,Jun S

更新日期：2016-02-01 00:00:00

abstract：:Chaperones are centrally involved in the control of protein structure, function, localization and transport. A flurry of scientific activity continues to examine the molecular nature of chaperone-substrate recognition and the role of auxiliary chaperones (cohort proteins) and small molecules that expedite these proces...

journal_title：Current opinion in cell biology

authors： Kelley WL,Georgopoulos C

更新日期：1992-12-01 00:00:00

abstract：:The concept that ostensibly tissue-specific stem cells can give rise to cells of heterologous lineages has gained support from studies using purified hematopoietic stem cells and sensitive donor-cell tracking methods. The ability to exploit these findings in clinical settings will probably depend on new insights into ...

journal_title：Current opinion in cell biology

authors： Goodell MA

更新日期：2001-12-01 00:00:00

abstract：:Living cells must be able to switch between growth and differentiation with high fidelity and precise spatial control to ensure that normal tissue patterns are formed in the embryo and maintained throughout adult life. Most work on cell proliferation focuses on elucidating the signaling pathways responsible for contro...

journal_title：Current opinion in cell biology

authors： Mammoto A,Ingber DE

更新日期：2009-12-01 00:00:00

abstract：:Within the class of integral membrane proteins, the bacterial porins display a remarkable resistance to denaturants and proteases. This stability is probably crucial for the formation of highly ordered, three-dimensional crystals. Structural analysis of these crystals has been possible in atomic detail. This analysis ...

journal_title：Current opinion in cell biology

authors： Schulz GE

更新日期：1993-08-01 00:00:00

abstract：:The structure of mitochondria is highly dynamic. Mitochondrial shape is cell-type specific and can be modified to meet changing requirements in energy production, calcium homeostasis, lipid biogenesis, fatty acid synthesis and other mitochondrial activities. This is achieved by modulating the dynamic properties of mit...

journal_title：Current opinion in cell biology

authors： Hoppins S

更新日期：2014-08-01 00:00:00

abstract：:Hermansky-Pudlak syndrome defines a group of genetic disorders characterized by defects in organelles of the endosomal-lysosomal system, most notably melanosomes and platelet-dense granules. About a dozen genes have been implicated in the pathogenesis of the disease in humans and mice. Most of these genes encode novel...

journal_title：Current opinion in cell biology

authors： Dell'Angelica EC

更新日期：2004-08-01 00:00:00

abstract：:Eukaryotic chromatin is a negatively charged polymer consisting of genomic DNA, histones, and various nonhistone proteins. Because of its highly charged character, the structure of chromatin varies greatly depending on the surrounding environment (i.e. cations etc.): from an extended 10-nm fiber, to a folded 30-nm fib...

journal_title：Current opinion in cell biology

authors： Maeshima K,Tamura S,Hansen JC,Itoh Y

更新日期：2020-06-01 00:00:00

abstract：:The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including ...

journal_title：Current opinion in cell biology

authors： Ferretti E,Hadjantonakis AK

更新日期：2019-12-01 00:00:00

abstract：:Polarity is defined by the segregation of cellular components along a defined axis. To polarize robustly, cells must be able to break symmetry and subsequently amplify these nascent asymmetries. Finally, asymmetric localization of signaling molecules must be translated into functional regulation of downstream effector...

journal_title：Current opinion in cell biology

authors： Peglion F,Goehring NW

更新日期：2019-10-01 00:00:00

abstract：:The advent of green fluorescent protein technology, its use in photobleaching experiments and the development of methods to rapidly acquire images and analyze complex datasets have opened the door to unraveling the mechanisms of nuclear functions in living cells. Studies over the past few years have characterized the ...

journal_title：Current opinion in cell biology

authors： Janicki SM,Spector DL

更新日期：2003-04-01 00:00:00

abstract：:Polarising a cell or an embryo is a crucial and recurrent event during development, as it is important for cell differentiation and migration. Cells can become polarised along their apical-basal axis and also within the plane of the tissue layer to which they belong. The embryo develops three axes: the anteroposterior...

journal_title：Current opinion in cell biology

authors： Wedlich D

更新日期：2002-10-01 00:00:00

abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...

journal_title：Current opinion in cell biology

authors： Shaw TJ,Martin P

更新日期：2016-10-01 00:00:00

abstract：:Force arising from actin polymerization and myosin activity drives a number of different actin-based cell movements. Several new reports support previous data suggesting that actin polymerization drives lamellipodial protrusion and bacterial propulsion, and one report describes a more indirect role for actin assembly ...

journal_title：Current opinion in cell biology

authors： Cramer LP,Mitchison TJ,Theriot JA

更新日期：1994-02-01 00:00:00

abstract：:Classical heterochromatin chromosomal landmarks, such as centromeres and telomeres, are characterized by specific chromatin signatures. Among these, the incorporation of histone variants has recently emerged as an important feature. Using the centromere as a paradigm, we consider the role of histone variant dynamics i...

journal_title：Current opinion in cell biology

authors： Boyarchuk E,Montes de Oca R,Almouzni G

更新日期：2011-06-01 00:00:00

abstract：:Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic...

journal_title：Current opinion in cell biology

authors： Burke B

更新日期：2018-06-01 00:00:00

abstract：:Mammalian Unc-51-like kinases 1 and 2 (ULK1 and ULK2) belong to the ULK/Atg1 family of serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 is best known for regulating flux through the autophagy pathway, it has evolutionarily conserved noncanonical functions in protein trafficking th...

journal_title：Current opinion in cell biology

authors： Wang B,Kundu M

更新日期：2017-04-01 00:00:00

abstract：:In the past year, major advances have been made in our understanding of the regulation of phosphoinositidase C, and of the action of the inositol trisphosphate receptor and how it may generate 'quantal' Ca2+ release. The functions of inositol tetrakisphosphate and of the 3-phosphorylated inositol lipids continue to ge...

journal_title：Current opinion in cell biology

authors： Irvine RF

更新日期：1992-04-01 00:00:00

abstract：:The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...

journal_title：Current opinion in cell biology

authors： Impens F,Vandekerckhove J,Gevaert K

更新日期：2010-12-01 00:00:00

abstract：:A defining feature of eukaryotic cells is the nucleus, which houses the genome inside the nuclear envelope (NE): a double lipid bilayer that separates the nuclear and cytoplasmic materials. Although the NE is commonly viewed as a barrier that is overcome only by embedded nuclear pore complexes (NPCs) that facilitate n...

journal_title：Current opinion in cell biology

authors： Smoyer CJ,Jaspersen SL

更新日期：2014-02-01 00:00:00