Abstract:
:HOM/Hox genes are master regulatory switches that specify axial identity and control the growth and differentiation of groups of cells related by position. HOM/Hox genes function combinatorially and hierarchically to specify cell fate. Some of the genes they regulate and that mediate specific identify functions have been identified. Research in Drosophila has shown that HOM genes are continuously required during development for correct axial identity.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Botas Jdoi
10.1016/0955-0674(93)90086-6subject
Has Abstractpub_date
1993-12-01 00:00:00pages
1015-22issue
6eissn
0955-0674issn
1879-0410pii
0955-0674(93)90086-6journal_volume
5pub_type
杂志文章,评审abstract::Diverse post-translational modifications of histone amino termini represent an important epigenetic mechanism for the organisation of chromatin structure and the regulation of gene activity. Within the past two years, great progress has been made in understanding the functional implications of histone methylation; in ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(02)00335-6
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abstract::The pancreas is derived from the foregut endoderm during embryonic development. After gastrulation and endoderm germ layer formation complex morphogenetic events coupled with cell differentiation programs pattern the gut tube and induce pancreas organogenesis. This results in formation of exocrine, ductal and hormone-...
journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2012.01.004
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:1999-02-01 00:00:00
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
abstract::In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single cell level have revealed that transcriptional kinetics are high...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2011.09.004
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abstract::The Polycomb group proteins are best known for their role as epigenetic regulators of the fly homeotic (Hox) gene clusters, but it has long been clear that these well conserved proteins have many other targets. For example, they are vital for maintaining both the pluripotency of stem cells and the identity of differen...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2007.04.010
更新日期:2007-06-01 00:00:00
abstract::Piwi-interacting RNAs (piRNAs) were reported in 2006 as a novel class of small non-coding RNAs associated with Piwi proteins of the Argonaute/Piwi family. Recent studies have revealed not only the biogenesis of piRNAs and their roles in transposon silencing, but also the function of the Piwi-piRNA pathway in epigeneti...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2013.01.010
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2019.07.018
更新日期:2020-02-01 00:00:00
abstract::Cellular plasticity is now recognized as a fundamental feature of tissue biology. The steady-state differentiation of stem and progenitor cells into mature cells is, in itself, the index form of cellular plasticity in adult organisms. Following injury, when it is critical to quickly regenerate and restore tissue integ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2018.01.003
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(95)80085-9
更新日期:1995-06-01 00:00:00
abstract::Germline stem cells (GSCs) sustain gametogenesis during the life of organisms. Recent progress has substantially extended our understanding of GSC behavior, including the mechanisms of stem cell self-renewal, asymmetric stem cell division, stem cell niches, dedifferentiation, and tissue aging. GSCs typically are highl...
journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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更新日期:1996-10-01 00:00:00
abstract::While canonical 3'end modifications of mRNAs or tRNAs are well established, recent technological advances in RNA analysis have given us a glimpse of how widespread other types of distinctive 3'end modifications appear to be. Next to alternative nuclear or cytoplasmic polyadenylation mechanisms, evidence accumulated fo...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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abstract::Several GPCRs, including receptors previously thought to signal primarily from the cell surface, have been recently shown to signal from many intracellular compartments. This raises the idea that signaling by any given receptor is spatially encoded in the cell, with distinct sites of signal origin dictating distinct d...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:2019-04-01 00:00:00
abstract::The number and variety of factors underlying control of gene expression have been frequently underestimated. Non-coding RNAs generated through pervasive transcription have recently been implicated in shaping the transcriptional landscape in different organisms from bacteria to higher eukaryotes, adding a previously un...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2015.04.011
更新日期:2015-06-01 00:00:00
abstract::Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones, and various associated proteins. Over the past ten years, our view of chromatin has shifted from a static regular structure to a dynamic and highly variable configuration. While the details are not fully understood yet, chromatin ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2019.02.003
更新日期:2019-06-01 00:00:00
abstract::Cilia (and flagella) are microtubule-based protrusions that are found in single or multiple copies on the surface of most eukaryotic cells. Defects in cilia formation and/or function have now been correlated with an expanding spectrum of human genetic diseases termed ciliopathies. Recent work indicates that cilia are ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2016.05.004
更新日期:2016-08-01 00:00:00
abstract::The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...
journal_title:Current opinion in cell biology
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更新日期:2010-12-01 00:00:00
abstract::Commitment to division requires that cells sense, interpret, and respond appropriately to multiple signals. In most eukaryotes, cells commit to division in G1 before DNA replication. Beyond a point, known as Start in yeast and the restriction point in mammals, cells will proceed through the cell cycle despite changes ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2013.07.010
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abstract::Cell competition is a short-range intercellular communication, in which cells compare their fitness with that of their neighbors and eliminate the cells with relatively lower fitness. It is considered important for the formation and maintenance of healthy tissues; however, its exact role during development, especially...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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