Abstract：
:Mitochondria are classically known as the essential energy producers in cells. As such, the activation of mitochondrial metabolism upon cellular differentiation was deemed a necessity to fuel the high metabolic needs of differentiated cells. However, recent studies have revealed a direct role for mitochondrial activity in the regulation of stem cell fate and differentiation. Several components of mitochondrial metabolism and respiration have now been shown to regulate different aspects of stem cell differentiation through signaling, transcriptional, proteomic and epigenetic modulations. In light of these findings mitochondrial metabolism is no longer considered a consequence of cellular differentiation, but rather a key regulatory mechanism of this process. This review will focus on recent progress that defines mitochondria as the epicenters for the regulation of stem cell fate decisions.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Khacho M,Slack RSdoi
10.1016/j.ceb.2017.11.003subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1-8eissn
0955-0674issn
1879-0410pii
S0955-0674(17)30137-0journal_volume
49pub_type
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