Abstract:
:The structure and integrity of the mitochondrial compartment are features essential for it to function efficiently. The maintenance of mitochondrial structure in cells ranging from yeast to humans has been shown to require both ongoing fission and fusion. Recent characterization of many of the molecular components that direct mitochondrial fission and fusion events have led to a more complete understanding of how these processes take place. Further, mitochondrial fragmentation observed when cells undergo apoptosis requires mitochondrial fission, underlying the importance of mitochondrial dynamics in cellular homeostasis. Mitochondrial structure also impacts mitochondrial DNA inheritance. Recent studies suggest that faithful transmission of mitochondrial DNA to daughter cells might require a mitochondrial membrane tethering apparatus.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Scott SV,Cassidy-Stone A,Meeusen SL,Nunnari Jdoi
10.1016/s0955-0674(03)00070-xsubject
Has Abstractpub_date
2003-08-01 00:00:00pages
482-8issue
4eissn
0955-0674issn
1879-0410pii
S095506740300070Xjournal_volume
15pub_type
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