Transcription factors: positive and negative regulators of cell growth and disease.

abstract：:The mitotic and meiotic cell cycle share many regulators, but there are also important differences between the two processes. The meiotic maturation of Xenopus oocytes has proved useful for understanding the regulation of Cdc2-cyclin-B, a key activator of G2/M progression. New insights have been made recently into the...

journal_title：Current opinion in cell biology

authors： Nebreda AR,Ferby I

更新日期：2000-12-01 00:00:00

abstract：:Cellular asymmetries have been proposed to play a role in plant embryogenesis. Genetic studies of Arabidopsis and other experimental approaches in several plant species have addressed the origins of cellular asymmetry in specific cases. Although zygote polarity, which precedes the formation of the apical-basal axis of...

journal_title：Current opinion in cell biology

authors： Jürgens G,Grebe M,Steinmann T

更新日期：1997-12-01 00:00:00

abstract：:Inability to meet protein folding demands within the endoplasmic reticulum (ER) activates the unfolded protein response (UPR), a signaling pathway with both adaptive and apoptotic outputs. While some secretory cell types have a remarkable ability to increase protein folding capacity, their upper limits can be reached ...

journal_title：Current opinion in cell biology

authors： Shore GC,Papa FR,Oakes SA

更新日期：2011-04-01 00:00:00

abstract：:Blood vessel development is a vital process during embryonic development, during tissue growth, regeneration and disease processes in the adult. In the past decade researchers have begun to unravel basic molecular mechanisms that regulate the formation of vascular lumen, sprouting angiogenesis, fusion of vessels, and ...

journal_title：Current opinion in cell biology

authors： Wacker A,Gerhardt H

更新日期：2011-12-01 00:00:00

abstract：:Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy bala...

journal_title：Current opinion in cell biology

authors： Wu Z,Puigserver P,Spiegelman BM

更新日期：1999-12-01 00:00:00

abstract：:Antigen processing leads to binding of antigenic peptides to major histocompatibility complex (MHC) molecules, and these peptide-MHC complexes are recognized by T cells. The class I and class II MHC antigen processing pathways employ different mechanisms and patterns of intracellular transport that allow the two class...

journal_title：Current opinion in cell biology

authors： Harding CV,Geuze HJ

更新日期：1993-08-01 00:00:00

abstract：:Evolutionarily conserved from yeast to man, mitogen-activated protein kinase (MAPK) pathways respond to a variety of disparate signals which induce differentiation, proliferation, or changes in intracellular enzyme regulation. Recent advances have identified two new mammalian MAPK relatives, JNK1 and p38, and the path...

journal_title：Current opinion in cell biology

authors： Waskiewicz AJ,Cooper JA

更新日期：1995-12-01 00:00:00

abstract：:The principal subunits of a large superfamily of plasma-membrane cation channels are functionally autonomous in ion conductance and in gating by membrane potential and intracellular ligands. Recent work has located the structural elements responsible for the ion conductance and gating of these channels. These studies ...

journal_title：Current opinion in cell biology

authors： Catterall WA

更新日期：1994-08-01 00:00:00

abstract：:Recently there have been advances in studies of the molecular biology of the receptor for CNTF. In contrast with the receptors for other known neurotrophic factors, which belong to the family of receptor tyrosine kinases, the CNTF receptor belongs to the family of cytokine receptors. This review will describe the stru...

journal_title：Current opinion in cell biology

authors： Davis S,Yancopoulos GD

更新日期：1993-04-01 00:00:00

abstract：:The study of eukaryotic telomeres at the molecular level began with the discovery of short, tandem repeats at Tetrahymena chromosome ends. In the following two decades, major insights about telomere structure and function have come from investigations of telomerase, the DNA polymerase that synthesizes these repeats. I...

journal_title：Current opinion in cell biology

authors： Collins K

更新日期：1996-06-01 00:00:00

abstract：:The Arp2/3 complex is necessary for nucleating the formation of branched networks of actin filaments at the cell cortex, and an increasing number of proteins able to activate the Arp2/3 complex have been described. The Wiskott-Aldrich syndrome protein (WASP) family and cortactin comprise the large majority of the know...

journal_title：Current opinion in cell biology

authors： Weaver AM,Young ME,Lee WL,Cooper JA

更新日期：2003-02-01 00:00:00

abstract：:Recent advances in understanding spatial genome organization inside the nucleus have shown that chromatin is compartmentalized into megabase-scale units known as topologically associating domains (TADs). In further studies, TADs were linked to differing transcriptional activity, suggesting that they might provide a sc...

journal_title：Current opinion in cell biology

authors： Ibrahim DM,Mundlos S

更新日期：2020-06-01 00:00:00

abstract：:Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functi...

journal_title：Current opinion in cell biology

authors： Will CL,Lührmann R

更新日期：1997-06-01 00:00:00

abstract：:Cellular plasticity is now recognized as a fundamental feature of tissue biology. The steady-state differentiation of stem and progenitor cells into mature cells is, in itself, the index form of cellular plasticity in adult organisms. Following injury, when it is critical to quickly regenerate and restore tissue integ...

journal_title：Current opinion in cell biology

authors： Paksa A,Rajagopal J

更新日期：2017-12-01 00:00:00

abstract：:Metastatic cancer cells produce invasive membrane protrusions called invadopodia and pseudopodia, which play a central role in driving cancer cell dissemination in the body. Malignant cells use these structures to attach to and degrade extracellular matrix proteins, generate force for cell locomotion, and to penetrate...

journal_title：Current opinion in cell biology

authors： Klemke RL

更新日期：2012-10-01 00:00:00

abstract：:Cell-cell signalling is an essential process in the formation of multicellular organisms. Notch is the receptor of an evolutionarily conserved signalling pathway regulating numerous developmental decisions. Indeed, its misregulation is linked to multiple developmental and physiological disorders. Notch and its ligands...

journal_title：Current opinion in cell biology

authors： Le Borgne R

更新日期：2006-04-01 00:00:00

abstract：:Kinases belonging to the mitogen-activated protein kinase (MAPK) family are used throughout evolution to control the cellular responses to external signals such as growth factors, nutrient status, stress or inductive signals. Many important substrates for MAPKs are transcription factors, and both the genetic and the b...

journal_title：Current opinion in cell biology

authors： Treisman R

更新日期：1996-04-01 00:00:00

abstract：:Focal adhesion kinase (pp125FAK), a protein tyrosine kinase, has recently been suggested to regulate aspects of signalling induced by integrins and by certain growth factor and hormone receptors. New studies indicate that the domains of pp125FAK regulate its interactions with integrin subunits, other protein tyrosine ...

journal_title：Current opinion in cell biology

authors： Schaller MD,Parsons JT

更新日期：1994-10-01 00:00:00

abstract：:Research over the past two decades has defined a window of time in the early/mid G1 phase of the cell cycle during which mammalian cells are responsive to extracellular signals. Recent evidence indicates that this period ends with the phosphorylation of the retinoblastoma protein, enabling the cells to pass through th...

journal_title：Current opinion in cell biology

authors： Planas-Silva MD,Weinberg RA

更新日期：1997-12-01 00:00:00

abstract：:Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate ...

journal_title：Current opinion in cell biology

authors： Garrod D,Chidgey M,North A

更新日期：1996-10-01 00:00:00

abstract：:A major goal in cell biology is to understand the functional organization of macromolecular complexes in vivo. Electron microscopy is helping cell biologists to achieve this goal, thanks to its ability to resolve structural details in the nanometer range. While issues related to specimen preparation, imaging, and imag...

journal_title：Current opinion in cell biology

authors： Hoenger A,McIntosh JR

更新日期：2009-02-01 00:00:00

abstract：:Senescence represents a permanent exit from the cell cycle and its role in curtailing the proliferation of damaged and potentially oncogenic cells has relevance both as a front-line defense against cancer and as an underlying cause of aging. The retinoblastoma protein (RB) and p53 tumor suppressors are central to the ...

journal_title：Current opinion in cell biology

authors： Chandler H,Peters G

更新日期：2013-12-01 00:00:00

abstract：:Neural induction is the process by which embryonic cells in the ectoderm make a decision to acquire a neural fate (to form the neural plate) rather than give rise to other structures such as epidermis or mesoderm. An influential model proposed a decade ago, the 'default model', postulated that ectodermal cells will be...

journal_title：Current opinion in cell biology

authors： Stern CD

更新日期：2006-12-01 00:00:00

abstract：:The control of translation and mRNA degradation plays a key role in the regulation of eukaryotic gene expression. In the cytosol, mRNAs engaged in translation are distributed throughout the cytosol, while translationally inactive mRNAs can accumulate in P bodies, in complex with mRNA degradation and translation repres...

journal_title：Current opinion in cell biology

authors： Balagopal V,Parker R

更新日期：2009-06-01 00:00:00

abstract：:How are cell morphogenesis and cell cycle coordinated? The fission yeast is a rod-shaped unicellular organism widely used to study how a cell self-organizes in space and time. Here, we discuss recent advances in understanding how the cell acquires and maintains its regular rod shape and uses it to control cell divisio...

journal_title：Current opinion in cell biology

authors： Hachet O,Bendezú FO,Martin SG

更新日期：2012-12-01 00:00:00

abstract：:Like other spectrin repeat proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton. However nuclear envelope (NE) nesprins, uniquely hardwire the nuclear lamina to the cytoskeleton and molecular motors. Emerging evidence suggests that nesprins also form a ...

journal_title：Current opinion in cell biology

authors： Mellad JA,Warren DT,Shanahan CM

更新日期：2011-02-01 00:00:00

abstract：:Actin polymerization generates the force that deforms the cell membrane, pulls the cell forward and propels endosomes and bacteria within the cell. The mechanism of force generation has been probed using experimental biomimetic systems where force generation and movement occur by the same actin-polymerization processe...

journal_title：Current opinion in cell biology

authors： Plastino J,Sykes C

更新日期：2005-02-01 00:00:00

abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...

journal_title：Current opinion in cell biology

authors： Shaw TJ,Martin P

更新日期：2016-10-01 00:00:00

abstract：:Telomeres, the natural termini of eukaryotic chromosomes, have been the subject of intense interest during the last decade because of the roles that these chromosome termini perform in both cancer and aging. As we become more cognizant of the consequences of telomere dysfunction on several aspects of human health, sig...

journal_title：Current opinion in cell biology

authors： Bertuch AA,Lundblad V

更新日期：2006-06-01 00:00:00

abstract：:Force arising from actin polymerization and myosin activity drives a number of different actin-based cell movements. Several new reports support previous data suggesting that actin polymerization drives lamellipodial protrusion and bacterial propulsion, and one report describes a more indirect role for actin assembly ...

journal_title：Current opinion in cell biology

authors： Cramer LP,Mitchison TJ,Theriot JA

更新日期：1994-02-01 00:00:00