Regulation of the meiotic cell cycle in oocytes.

abstract：:Far from being simple 'bags' of enzymes, bacteria are richly endowed with ultrastructures that challenge and expand standard definitions of the cytoskeleton. Here we review rods, rings, twisted pairs, tubes, sheets, spirals, moving patches, meshes and composites, and suggest defining the term 'bacterial cytoskeleton' ...

journal_title：Current opinion in cell biology

authors： Pilhofer M,Jensen GJ

更新日期：2013-02-01 00:00:00

abstract：:Although it is universally accepted that protein synthesis occurs in the cytoplasm, the possibility that translation can also take place in the nucleus has been hotly debated. Reports have been published claiming to demonstrate nuclear translation, but alternative explanations for these results have not been excluded,...

journal_title：Current opinion in cell biology

authors： Dahlberg JE,Lund E

更新日期：2004-06-01 00:00:00

abstract：:In the past decade, studies into the way in which intracellular bacterial pathogens hijack and subvert their hosts have provided many important insights into regulation of the actin cytoskeleton and cell motility, in addition to increasing our understanding of the infection process. Viral pathogens, however, may ultim...

journal_title：Current opinion in cell biology

authors： Ploubidou A,Way M

更新日期：2001-02-01 00:00:00

abstract：:Many aspects of cell physiology are controlled by protein kinases and phosphatases, which together determine the phosphorylation state of targeted substrates. Some of these target proteins are themselves kinases or phosphatases or other components of a regulatory network characterized by feedback and feed-forward loop...

journal_title：Current opinion in cell biology

authors： Novak B,Kapuy O,Domingo-Sananes MR,Tyson JJ

更新日期：2010-12-01 00:00:00

abstract：:Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones, and various associated proteins. Over the past ten years, our view of chromatin has shifted from a static regular structure to a dynamic and highly variable configuration. While the details are not fully understood yet, chromatin ...

journal_title：Current opinion in cell biology

authors： Maeshima K,Ide S,Babokhov M

更新日期：2019-06-01 00:00:00

abstract：:Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail. The cilium is assembled from mature (mother) centr...

journal_title：Current opinion in cell biology

authors： Kim S,Dynlacht BD

更新日期：2013-08-01 00:00:00

abstract：:Blood vessel development is a vital process during embryonic development, during tissue growth, regeneration and disease processes in the adult. In the past decade researchers have begun to unravel basic molecular mechanisms that regulate the formation of vascular lumen, sprouting angiogenesis, fusion of vessels, and ...

journal_title：Current opinion in cell biology

authors： Wacker A,Gerhardt H

更新日期：2011-12-01 00:00:00

abstract：:Flowers and shoots are derived from specialized groups of stem cells termed meristems. Recent studies in Arabidopsis have identified factors that contribute to meristem structure and identity, such as CLAVATA1, CLAVATA3, and SHOOTMERISTEMLESS, which act in both shoot and flower meristems, as well as LEAFY and APETALA1...

journal_title：Current opinion in cell biology

authors： Liljegren SJ,Yanofsky MF

更新日期：1996-12-01 00:00:00

abstract：:The Golgi apparatus occupies a central position within the secretory pathway where it is a hub for vesicle trafficking. Distinct classes of transport vesicles traffic diverse cargoes into and out of this organelle, as well as between the different Golgi subcompartments. A key feature of Golgi trafficking is the specif...

journal_title：Current opinion in cell biology

authors： Witkos TM,Lowe M

更新日期：2017-08-01 00:00:00

abstract：:Recent discoveries have converged on the emerging enzymology that governs the G1-S phase transition of the mammalian somatic cell cycle. These discoveries have led to an appreciation of the regulatory role of proline-directed protein phosphorylation in molecular signalling, and have resulted in the identification of a...

journal_title：Current opinion in cell biology

authors： Hall FL,Vulliet PR

更新日期：1991-04-01 00:00:00

abstract：:The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the extracellular matrix to permit normal remodeling and contribute to pathological tissue destruction and tumor cell invasion. More recently, the identification of specific matrix and non-matrix substrates for MMPs and the elucidation of ...

journal_title：Current opinion in cell biology

authors： McCawley LJ,Matrisian LM

更新日期：2001-10-01 00:00:00

abstract：:Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal networks, made of actin filaments, microtubules, and intermediate filaments. These three types of cytoskeletal polymers have rather different structural and physical properties, enabling specific cellular functions. However, there ...

journal_title：Current opinion in cell biology

authors： Huber F,Boire A,López MP,Koenderink GH

更新日期：2015-02-01 00:00:00

abstract：:The proposition is forwarded that the cAMP-dependent protein kinase is one of quite a small class of enzymes wherein differential modes of binding of its multiple substrates make an important contribution to the end physiological response. It is postulated that a variety of different substrate affinities may have evol...

journal_title：Current opinion in cell biology

authors： Walsh DA,Glass DB,Mitchell RD

更新日期：1992-04-01 00:00:00

abstract：:The long-standing interest in centrioles and basal bodies stems from the evolutionary conservation of their structural design and from their dual mode of assembly (templated versus de novo), revealed by electron microscopic studies nearly four decades ago and unique for a subcellular organelle. Molecular dissection of...

journal_title：Current opinion in cell biology

authors： Beisson J,Wright M

更新日期：2003-02-01 00:00:00

abstract：:The insulin receptor substrates function at the heart of the insulin signalling network. It has recently become apparent that the intracellular localisation of these molecules is regulated in a precise manner that is critical for both the generation and the termination of the insulin signal. Some insulin receptor subs...

journal_title：Current opinion in cell biology

authors： Whitehead JP,Clark SF,Urso B,James DE

更新日期：2000-04-01 00:00:00

abstract：:Throughout their lifetimes, all cells experience force. These forces are sensed by cell surface adhesion receptors, such as the cadherins and integrins. Much attention has focused on identifying how these adhesion receptors transmit force. In contrast, less is known regarding how these force-activated pathways are int...

journal_title：Current opinion in cell biology

authors： Salvi AM,DeMali KA

更新日期：2018-10-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid and glucose homeostasis, inflammation and wound healing. In addition to ligand binding, phosphorylation can also regulate PPARs; the biological effects of phosphorylation depend on the stimulus, the kinase, the PPAR isotype, th...

journal_title：Current opinion in cell biology

authors： Gelman L,Michalik L,Desvergne B,Wahli W

更新日期：2005-04-01 00:00:00

abstract：:The materials cells are made of are strikingly different from man-made materials. Metabolism keeps cells out of equilibrium. Motor proteins and energy-consuming polymerization drive shape changes and motion. In contrast to macroscopic machines, though, there is no clear distinction between the force generators and the...

journal_title：Current opinion in cell biology

authors： Mackintosh FC,Schmidt CF

更新日期：2010-02-01 00:00:00

abstract：:Cell surface molecules, ligands, and solutes can be endocytosed into animal cells via several pathways in addition to clathrin-mediated endocytosis, which all seem to lead to canonical endosomes. It seems that viruses can enter and infect cells through most of, if not all, endocytic routes, having evolved different, s...

journal_title：Current opinion in cell biology

authors： Gruenberg J

更新日期：2009-08-01 00:00:00

abstract：:Emerging studies indicate that connexins have activities completely unrelated to gap junctions and, conversely, that non-connexin proteins can form gap junction channels. ...

journal_title：Current opinion in cell biology

authors： Stout C,Goodenough DA,Paul DL

更新日期：2004-10-01 00:00:00

abstract：:The zebrafish is rapidly increasing in popularity with developmental biologists. Driving this interest are the elegant methods for in vivo observations and recovery of early developmental mutations. The past year has seen the introduction of additional methods for in vivo manipulation of identified cells and the appli...

journal_title：Current opinion in cell biology

authors： Fulwiler C,Gilbert W

更新日期：1991-12-01 00:00:00

abstract：:Cellular microtubules are mosaic polymers assembled from multiple αβ-tubulin isoforms bearing chemically diverse posttranslational modifications. This tubulin diversity constitutes a combinatorial code that regulates microtubule interactions with cellular effectors and alters their intrinsic dynamic and mechanical pro...

journal_title：Current opinion in cell biology

authors： Roll-Mecak A

更新日期：2019-02-01 00:00:00

abstract：:Regulation of skeletal muscle determination and differentiation in vertebrates centers on a core regulatory network which is composed of two families of transcription factors, the MyoD group basic helix-loop-helix (bHLH) muscle regulatory factors (MRFs) and the myocyte enhancer factor 2 (MEF2) group of MADS-box regula...

journal_title：Current opinion in cell biology

authors： Yun K,Wold B

更新日期：1996-12-01 00:00:00

abstract：:Oocyte cytoplasmic factors can reprogramme the sperm genome during fertilisation or the somatic cell genome during cloning. Diverse reprogramming machinery acts sequentially and interdependently on the imported genome to drive it to totipotency, but their three-dimensional interactions in the cytoplasm remain unknown....

journal_title：Current opinion in cell biology

authors： Kang YK,Lee KK,Han YM

更新日期：2003-06-01 00:00:00

abstract：:Cells act as building blocks of multicellular organisms, forming higher-order structures at different biological scales. Niches, tissues and, ultimately, entire organisms consist of single cells that remain in constant communication. Emergence of developmental patterns and tissue architecture thus relies on single cel...

journal_title：Current opinion in cell biology

authors： Zinner M,Lukonin I,Liberali P

更新日期：2020-12-01 00:00:00

abstract：:Actin polymerization generates the force that deforms the cell membrane, pulls the cell forward and propels endosomes and bacteria within the cell. The mechanism of force generation has been probed using experimental biomimetic systems where force generation and movement occur by the same actin-polymerization processe...

journal_title：Current opinion in cell biology

authors： Plastino J,Sykes C

更新日期：2005-02-01 00:00:00

abstract：:Hermansky-Pudlak syndrome defines a group of genetic disorders characterized by defects in organelles of the endosomal-lysosomal system, most notably melanosomes and platelet-dense granules. About a dozen genes have been implicated in the pathogenesis of the disease in humans and mice. Most of these genes encode novel...

journal_title：Current opinion in cell biology

authors： Dell'Angelica EC

更新日期：2004-08-01 00:00:00

abstract：:The cortical force-generating machinery pulls on dynamic plus-ends of astral microtubules to control spindle position and orientation, which underlie division type specification and cellular patterning in many eukaryotic cells. A prior work identified cytoplasmic dynein, a minus-end directed microtubule motor, as a ke...

journal_title：Current opinion in cell biology

authors： Kiyomitsu T

更新日期：2019-10-01 00:00:00

abstract：:Research over the past two decades has defined a window of time in the early/mid G1 phase of the cell cycle during which mammalian cells are responsive to extracellular signals. Recent evidence indicates that this period ends with the phosphorylation of the retinoblastoma protein, enabling the cells to pass through th...

journal_title：Current opinion in cell biology

authors： Planas-Silva MD,Weinberg RA

更新日期：1997-12-01 00:00:00

abstract：:Over the last five decades more than 100 types of RNA modifications have been identified in organism of all kingdoms of life, yet their function and biological relevance remain largely elusive. The recent development of transcriptome-wide techniques to detect RNA modifications such as N(6)-methyladenosine (m(6)A) and ...

journal_title：Current opinion in cell biology

authors： Blanco S,Frye M

更新日期：2014-12-01 00:00:00