Antigen processing and intracellular traffic of antigens and MHC molecules.

abstract：:Polarising a cell or an embryo is a crucial and recurrent event during development, as it is important for cell differentiation and migration. Cells can become polarised along their apical-basal axis and also within the plane of the tissue layer to which they belong. The embryo develops three axes: the anteroposterior...

journal_title：Current opinion in cell biology

authors： Wedlich D

更新日期：2002-10-01 00:00:00

abstract：:There is accumulating evidence that lateral assemblies (rafts) of sphingolipids and cholesterol form platforms that serve to support numerous cellular events in membrane traffic and signal transduction. Raft membrane microdomains are thought to function by preferentially associating with specific proteins while exclud...

journal_title：Current opinion in cell biology

authors： Harder T,Simons K

更新日期：1997-08-01 00:00:00

abstract：:The arrangement and dynamics of chromosomes inside the nucleus of mammalian cells have been studied intensively over the last two years. Although chromosomes are relatively immobile and occupy non-random positions in interphase, their dynamic movements in mitosis have traditionally been assumed to randomize this arran...

journal_title：Current opinion in cell biology

authors： Gerlich D,Ellenberg J

更新日期：2003-12-01 00:00:00

abstract：:Mammalian cell biology is witnessing a new era in which cellular processes are explained through dynamic networks of interacting cellular components. In this fast-pacing field, where image-based RNAi screening is taking a central role, there is a strong need to improve ways to capture such interactions in space and ti...

journal_title：Current opinion in cell biology

authors： Sacher R,Stergiou L,Pelkmans L

更新日期：2008-08-01 00:00:00

abstract：:A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hier...

journal_title：Current opinion in cell biology

authors： Roskelley CD,Srebrow A,Bissell MJ

更新日期：1995-10-01 00:00:00

abstract：:Studies of various membrane trafficking steps over the past year indicate that membranes are tethered together prior to the interaction of v-SNAREs and t-SNAREs across the membrane junction. The tethering proteins identified to date are quite large, being either fibrous proteins or multimeric protein complexes. The te...

journal_title：Current opinion in cell biology

authors： Waters MG,Pfeffer SR

更新日期：1999-08-01 00:00:00

abstract：:The cerebral cortex is composed of hundreds of different types of neurons, which underlie its ability to perform highly complex neural processes. How cortical neurons are generated during development constitutes a major challenge in developmental neurosciences with important implications for brain repair and diseases....

journal_title：Current opinion in cell biology

authors： Tiberi L,Vanderhaeghen P,van den Ameele J

更新日期：2012-04-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) is a fundamental process governing morphogenesis in multicellular organisms. This process is also reactivated in a variety of diseases including fibrosis and in the progression of carcinoma. The molecular mechanisms of EMT were primarily studied in epithelial cell lines, lea...

journal_title：Current opinion in cell biology

authors： Thiery JP

更新日期：2003-12-01 00:00:00

abstract：:A major goal in cell biology is to understand the functional organization of macromolecular complexes in vivo. Electron microscopy is helping cell biologists to achieve this goal, thanks to its ability to resolve structural details in the nanometer range. While issues related to specimen preparation, imaging, and imag...

journal_title：Current opinion in cell biology

authors： Hoenger A,McIntosh JR

更新日期：2009-02-01 00:00:00

abstract：:1990 has been a year of continued exciting developments in cell cycle control. Progress has occurred in delineating the mechanism of activation of maturation-promoting factor during entry into mitosis and the mechanism of cyclin degradation responsible for exit from mitosis. Notable advances have also occurred in our ...

journal_title：Current opinion in cell biology

authors： Maller JL

更新日期：1991-04-01 00:00:00

abstract：:Cell competition is a short-range intercellular communication, in which cells compare their fitness with that of their neighbors and eliminate the cells with relatively lower fitness. It is considered important for the formation and maintenance of healthy tissues; however, its exact role during development, especially...

journal_title：Current opinion in cell biology

authors： Hashimoto M,Sasaki H

更新日期：2020-12-01 00:00:00

abstract：:Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression. ...

journal_title：Current opinion in cell biology

authors： Nigg EA

更新日期：1993-04-01 00:00:00

abstract：:Clathrin-mediated endocytosis (CME) is the main endocytic pathway supporting housekeeping functions in cells. However, CME may be too slow to internalize proteins from the cell surface during certain physiological processes such as reaction to stress hormones ('fight-or-flight' reaction), chemotaxis or compensatory en...

journal_title：Current opinion in cell biology

authors： Watanabe S,Boucrot E

更新日期：2017-08-01 00:00:00

abstract：:The activation of the serine/threonine kinase Raf-1 is proving to be an intricate multistep process. Recent advances in elucidating how Raf-1 becomes activated in response to signaling events have emphasized the role of phosphorylation and protein interactions in Raf-1 regulation. The picture clearly emerging is that ...

journal_title：Current opinion in cell biology

authors： Morrison DK,Cutler RE

更新日期：1997-04-01 00:00:00

abstract：:It is widely recognized that after endocytosis, internalized cargo is delivered to endosomes that act as sorting stations. The limiting membrane of endosomes contain specialized subregions, or microdomains, that represent distinct functions of the endosome, including regions competing for cargo capture leading to degr...

journal_title：Current opinion in cell biology

authors： Norris A,Grant BD

更新日期：2020-08-01 00:00:00

abstract：:At the time of this writing, searching Google Scholar for 'light-sheet microscopy' returns almost 8500 results; over three-quarters of which were published in the last 5 years alone. Searching for other advanced imaging methods in the last 5 years yields similar results: 'super-resolution microscopy' (>16 000), 'singl...

journal_title：Current opinion in cell biology

authors： Lemon WC,McDole K

更新日期：2020-10-01 00:00:00

abstract：:Cell surface molecules, ligands, and solutes can be endocytosed into animal cells via several pathways in addition to clathrin-mediated endocytosis, which all seem to lead to canonical endosomes. It seems that viruses can enter and infect cells through most of, if not all, endocytic routes, having evolved different, s...

journal_title：Current opinion in cell biology

authors： Gruenberg J

更新日期：2009-08-01 00:00:00

abstract：:The adipose tissue of mammals represents a dynamic organ disseminated throughout the body. It fluctuates in abundance according to the availability of metabolic energy supplies. Mature adipose tissue communicates with the central nervous system via a hormonal circuit that controls satiety. Adipogenesis can be recapitu...

journal_title：Current opinion in cell biology

authors： Yeh WC,McKnight SL

更新日期：1995-12-01 00:00:00

abstract：:Genetic analysis in model organisms has recently achieved a detailed molecular description of many key cellular processes controlling embryonic morphogenesis. To understand higher order tissue morphogenesis, we now need to define how these processes become integrated across different cell groups and cell layers. Here,...

journal_title：Current opinion in cell biology

authors： Zhang H,Gally C,Labouesse M

更新日期：2010-10-01 00:00:00

abstract：:Despite some recent setbacks, it remains clear that adult stem cells under appropriate experimental conditions can at some frequency exhibit a wider range of differentiation potentials than previously appreciated. This is underscored by the recent demonstration of the extensive differentiation potential of mesenchymal...

journal_title：Current opinion in cell biology

authors： Joshi CV,Enver T

更新日期：2002-12-01 00:00:00

abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...

journal_title：Current opinion in cell biology

authors： Shaw TJ,Martin P

更新日期：2016-10-01 00:00:00

abstract：:The nucleoskeleton is composed of many interacting structural proteins that provide the framework for DNA replication, transcription and a variety of other nuclear functions. For example, the type-V intermediate filament proteins, the lamins, and their associated proteins (e.g. Lap2alpha) play important roles in DNA r...

journal_title：Current opinion in cell biology

authors： Shumaker DK,Kuczmarski ER,Goldman RD

更新日期：2003-06-01 00:00:00

abstract：:The mitogen-activated protein kinase appears to be regulated by another growth factor regulated kinase, the mitogen-activated protein kinase activator. In the past year, much progress has been made in purifying and characterizing the mitogen-activated protein kinase activator, in determining its primary structure, and...

journal_title：Current opinion in cell biology

authors： Ahn NG,Seger R,Krebs EG

更新日期：1992-12-01 00:00:00

abstract：:Protein splicing is a series of enzymatic events involving intramolecular protein breakage, rejoining and intron homing, in which introns are able to promote the recombinative transposition of their own coding sequences. Eukaryotic and prokaryotic spliced proteins have conserved similar gene structure, but little amin...

journal_title：Current opinion in cell biology

authors： Neff NF

更新日期：1993-12-01 00:00:00

abstract：:Integrins have the ability to organise macromolecular structures both inside and outside the cell. Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word. ...

journal_title：Current opinion in cell biology

authors： Brown NH

更新日期：2000-10-01 00:00:00

abstract：:Asymmetric cell division (ACD) is the fundamental process through which one cell divides into two cells with different fates. In animals, it is crucial for the generation of cell-type diversity and for stem cells, which use ACD both to self-renew and produce one differentiating daughter cell. One of the most prominent...

journal_title：Current opinion in cell biology

authors： Loyer N,Januschke J

更新日期：2020-02-01 00:00:00

abstract：:Recent evidence corroborates the idea that the structure of the nucleolus need not be strictly maintained for proper function, suggesting that the organelle is composed of supramolecular assemblies formed during rRNA synthesis. More controversial is whether the nucleolus exists in the absence of rRNA synthesis and whe...

journal_title：Current opinion in cell biology

authors： Mélèse T,Xue Z

更新日期：1995-06-01 00:00:00

abstract：:Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by GEFs (guanine nucleotide exchange factors) and then inactivated by GAPs (GTPase activating proteins). Recent evidence shows that in addition to activati...

journal_title：Current opinion in cell biology

authors： Lamber EP,Siedenburg AC,Barr FA

更新日期：2019-08-01 00:00:00

abstract：:Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic network that through interactions with all vital cell structures, provides an effective mechanochemical integrator of morphology and function, absolutely necessary for intra-cellular and intercellular coordination of all muscle fun...

journal_title：Current opinion in cell biology

authors： Capetanaki Y,Papathanasiou S,Diokmetzidou A,Vatsellas G,Tsikitis M

更新日期：2015-02-01 00:00:00

abstract：:A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Cell Biology. ...

journal_title：Current opinion in cell biology

authors： Pines J,Lafont F

更新日期：2001-08-01 00:00:00