Abstract:
:Recent evidence corroborates the idea that the structure of the nucleolus need not be strictly maintained for proper function, suggesting that the organelle is composed of supramolecular assemblies formed during rRNA synthesis. More controversial is whether the nucleolus exists in the absence of rRNA synthesis and whether it interacts with the nuclear scaffold. The simultaneous and highly integrative nature of building a ribosome is reflected in the numerous observations showing that proteins involved in all aspects of ribosomal biogenesis affect pre-rRNA processing. The identification of several new nucleolar proteins without an obvious role in pre-rRNA metabolism may provide the field with long sought after assembly factors that might be key players in eukaryotic ribosome biogenesis.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Mélèse T,Xue Zdoi
10.1016/0955-0674(95)80085-9subject
Has Abstractpub_date
1995-06-01 00:00:00pages
319-24issue
3eissn
0955-0674issn
1879-0410pii
0955-0674(95)80085-9journal_volume
7pub_type
杂志文章,评审abstract::Eukaryotes silence gene expression in the presence of double-stranded RNA homologous to the silenced gene. Silencing occurs by the targeted degradation of mRNA. Biochemical reactions that recapitulate this phenomenon generate RNA fragments of 21--23 nucleotides from the double-stranded RNA. These stably associate with...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(00)00204-0
更新日期:2001-04-01 00:00:00
abstract::The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2019.07.012
更新日期:2019-12-01 00:00:00
abstract::The Polycomb group proteins are best known for their role as epigenetic regulators of the fly homeotic (Hox) gene clusters, but it has long been clear that these well conserved proteins have many other targets. For example, they are vital for maintaining both the pluripotency of stem cells and the identity of differen...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2007.04.010
更新日期:2007-06-01 00:00:00
abstract::Myosins are a large family of structurally diverse mechanoenzymes which, upon interaction with actin filaments, convert energy from ATP hydrolysis into mechanical force. Consistent with the ubiquitous association of actin with membranes, many of these novel myosins are membrane-associated. In the past two years, evide...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(95)80017-4
更新日期:1995-08-01 00:00:00
abstract::It has become clear that many vital metabolic circuits and early developmental programs are regulated translationally. Until recently, the mechanisms underlying most of these observations were poorly understood. The past year has witnessed several important advances in the understanding of how the translational appara...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(95)80095-6
更新日期:1995-06-01 00:00:00
abstract::In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(99)80036-2
更新日期:1999-04-01 00:00:00
abstract::The Arp2/3 complex is necessary for nucleating the formation of branched networks of actin filaments at the cell cortex, and an increasing number of proteins able to activate the Arp2/3 complex have been described. The Wiskott-Aldrich syndrome protein (WASP) family and cortactin comprise the large majority of the know...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(02)00015-7
更新日期:2003-02-01 00:00:00
abstract::Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau pro...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(00)00194-0
更新日期:2001-04-01 00:00:00
abstract::Over the last five decades more than 100 types of RNA modifications have been identified in organism of all kingdoms of life, yet their function and biological relevance remain largely elusive. The recent development of transcriptome-wide techniques to detect RNA modifications such as N(6)-methyladenosine (m(6)A) and ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2014.06.006
更新日期:2014-12-01 00:00:00
abstract::A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2016.04.001
更新日期:2016-10-01 00:00:00
abstract::Extracellular matrix (ECM) induces and maintains the differentiation of epithelial cells, not by totally altering their state of differentiation, but by activating overt differentiation. Recent studies of cultured mammary cells provide an elegant molecular analysis of this kind of progressive cell differentiation. Oth...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(93)90088-8
更新日期:1993-12-01 00:00:00
abstract::AB toxins deliver their enzymatically active A domain to the cytosol. Some AB-toxins are able to penetrate cellular membranes from endosomes where the low pH triggers their translocation. One such toxin is diphtheria toxin and important features of its translocation mechanism have been unraveled during the last year. ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(00)00109-5
更新日期:2000-08-01 00:00:00
abstract::The zebrafish is rapidly increasing in popularity with developmental biologists. Driving this interest are the elegant methods for in vivo observations and recovery of early developmental mutations. The past year has seen the introduction of additional methods for in vivo manipulation of identified cells and the appli...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(91)90118-i
更新日期:1991-12-01 00:00:00
abstract::Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulated storage and release of lipids to fulfil their fundamental roles in energy metabolism, membrane synthesis and provision of lipid-derived signaling molecules. Although small LDs are observed in all types of eukaryotic c...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2017.02.002
更新日期:2017-08-01 00:00:00
abstract::Although it is universally accepted that protein synthesis occurs in the cytoplasm, the possibility that translation can also take place in the nucleus has been hotly debated. Reports have been published claiming to demonstrate nuclear translation, but alternative explanations for these results have not been excluded,...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2004.03.006
更新日期:2004-06-01 00:00:00
abstract::Peroxisomes are part of the ubiquitous set of eukaryotic organelles. They are small, single membrane bounded vesicles, specialized in the degradation of very-long-chain fatty acids and in synthesis of myelin lipids. Once considered inconspicuous, recent new insights in the formation and function of peroxisomes have re...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2013.05.004
更新日期:2013-08-01 00:00:00
abstract::In vitro experiments led to a simple model in which basal transcription factors sequentially assembled with RNA Polymerase II to generate a preinitiation complex (PIC). Emerging evidence indicates that PIC composition is not universal, but promoter-dependent. Active promoters are occupied by a mixed population of comp...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2009.03.006
更新日期:2009-06-01 00:00:00
abstract::The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are un...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/S0955-0674(99)80050-7
更新日期:1999-06-01 00:00:00
abstract::Several recent scientific and technical developments have made it possible to postulate the use of the 'magic bullet' concept; that is, the identification of specific antigens present on tumor cells that can be targeted either by therapeutic antibodies or by small molecules. The use of monoclonal antibodies in cancer,...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(03)00106-6
更新日期:2003-10-01 00:00:00
abstract::In the adult, angiogenesis, the formation of new blood vessels from pre-existing vasculature contributes to the pathogenesis of many disorders including cancer. The role of adhesion molecules, especially integrins, in pathological angiogenesis has long been the subject of investigation, mostly because of their potenti...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2008.06.007
更新日期:2008-10-01 00:00:00
abstract::Mammalian Unc-51-like kinases 1 and 2 (ULK1 and ULK2) belong to the ULK/Atg1 family of serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 is best known for regulating flux through the autophagy pathway, it has evolutionarily conserved noncanonical functions in protein trafficking th...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2017.02.011
更新日期:2017-04-01 00:00:00
abstract::Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and membranes. Innate immune cells and transformed cancer cells share the capacity for both constitutive and induced macropinocytosis, which...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2020.06.005
更新日期:2020-08-01 00:00:00
abstract::The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2010.08.021
更新日期:2010-12-01 00:00:00
abstract::Several recently discovered mammalian cell adhesion proteins recognize and bind to sialic acid-containing ligands. Reports concerning the molecular specificities of these interactions have been intriguing but somewhat confusing, partly because of pitfalls in methodology or interpretation. Nevertheless, these protein-c...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(92)90041-a
更新日期:1992-04-01 00:00:00
abstract::The adipose tissue of mammals represents a dynamic organ disseminated throughout the body. It fluctuates in abundance according to the availability of metabolic energy supplies. Mature adipose tissue communicates with the central nervous system via a hormonal circuit that controls satiety. Adipogenesis can be recapitu...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(95)80074-3
更新日期:1995-12-01 00:00:00
abstract::Oocyte cytoplasmic factors can reprogramme the sperm genome during fertilisation or the somatic cell genome during cloning. Diverse reprogramming machinery acts sequentially and interdependently on the imported genome to drive it to totipotency, but their three-dimensional interactions in the cytoplasm remain unknown....
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(03)00031-0
更新日期:2003-06-01 00:00:00
abstract::Tissue stem cells are found in specialized microenvironments (niches) where they are exposed to diverse systemic and local signals that are integrated with cell intrinsic factors to regulate stem cell behavior. In general, systemic signals are utilized to coordinate the response of tissues to acute or long-term change...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2012.01.004
更新日期:2012-04-01 00:00:00
abstract::Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functi...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(97)80003-8
更新日期:1997-06-01 00:00:00
abstract::The cortical force-generating machinery pulls on dynamic plus-ends of astral microtubules to control spindle position and orientation, which underlie division type specification and cellular patterning in many eukaryotic cells. A prior work identified cytoplasmic dynein, a minus-end directed microtubule motor, as a ke...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2019.03.001
更新日期:2019-10-01 00:00:00
abstract::A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(92)90077-p
更新日期:1992-08-01 00:00:00