Abstract：
:Although it is universally accepted that protein synthesis occurs in the cytoplasm, the possibility that translation can also take place in the nucleus has been hotly debated. Reports have been published claiming to demonstrate nuclear translation, but alternative explanations for these results have not been excluded, and other experiments argue against it. Much of the appeal of nuclear translation is that functional proofreading of newly made mRNAs in the nucleus would provide an efficient way to monitor mRNAs for the presence of premature termination codons, thereby avoiding the synthesis of deleterious proteins. mRNAs that are still in the nucleus-associated fraction of cells are subject to translational proofreading resulting in nonsense-mediated mRNA decay and perhaps nonsense-associated alternate splicing. However, these mRNAs are likely to be in the perinuclear cytoplasm rather than within the nucleus. Therefore, in the absence of additional evidence, we conclude that nuclear translation is unlikely to occur.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Dahlberg JE,Lund Edoi
10.1016/j.ceb.2004.03.006subject
Has Abstractpub_date
2004-06-01 00:00:00pages
335-8issue
3eissn
0955-0674issn
1879-0410pii
S0955067404000444journal_volume
16pub_type
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