Coactivator control of cardiovascular growth and remodeling.

abstract：:The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are un...

journal_title：Current opinion in cell biology

authors： Tacke R,Manley JL

更新日期：1999-06-01 00:00:00

abstract：:The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place th...

journal_title：Current opinion in cell biology

authors： Yonemura S

更新日期：2011-10-01 00:00:00

abstract：:Mammalian cell biology is witnessing a new era in which cellular processes are explained through dynamic networks of interacting cellular components. In this fast-pacing field, where image-based RNAi screening is taking a central role, there is a strong need to improve ways to capture such interactions in space and ti...

journal_title：Current opinion in cell biology

authors： Sacher R,Stergiou L,Pelkmans L

更新日期：2008-08-01 00:00:00

abstract：:Many aspects of cell physiology are controlled by protein kinases and phosphatases, which together determine the phosphorylation state of targeted substrates. Some of these target proteins are themselves kinases or phosphatases or other components of a regulatory network characterized by feedback and feed-forward loop...

journal_title：Current opinion in cell biology

authors： Novak B,Kapuy O,Domingo-Sananes MR,Tyson JJ

更新日期：2010-12-01 00:00:00

abstract：:The rate at which receptors have been cloned has recently increased dramatically--existing families have been extended and new families created. The rapid cloning by homology of 'orphan receptors' has also stimulated the development of a new reverse pharmacology. ...

journal_title：Current opinion in cell biology

authors： Libert F,Vassart G,Parmentier M

更新日期：1991-04-01 00:00:00

abstract：:It is widely recognized that after endocytosis, internalized cargo is delivered to endosomes that act as sorting stations. The limiting membrane of endosomes contain specialized subregions, or microdomains, that represent distinct functions of the endosome, including regions competing for cargo capture leading to degr...

journal_title：Current opinion in cell biology

authors： Norris A,Grant BD

更新日期：2020-08-01 00:00:00

abstract：:Misfolded and mistargeted proteins in the early secretory pathway present significant risks to the cell. A diverse and integrated network of quality control pathways protects the cell from these threats. We focus on the discovery of new mechanisms that contribute to this protective network. Biochemical and structural ...

journal_title：Current opinion in cell biology

authors： Phillips BP,Gomez-Navarro N,Miller EA

更新日期：2020-08-01 00:00:00

abstract：:Germline stem cells (GSCs) sustain gametogenesis during the life of organisms. Recent progress has substantially extended our understanding of GSC behavior, including the mechanisms of stem cell self-renewal, asymmetric stem cell division, stem cell niches, dedifferentiation, and tissue aging. GSCs typically are highl...

journal_title：Current opinion in cell biology

authors： Yuan H,Yamashita YM

更新日期：2010-12-01 00:00:00

abstract：:Cellular microtubules are mosaic polymers assembled from multiple αβ-tubulin isoforms bearing chemically diverse posttranslational modifications. This tubulin diversity constitutes a combinatorial code that regulates microtubule interactions with cellular effectors and alters their intrinsic dynamic and mechanical pro...

journal_title：Current opinion in cell biology

authors： Roll-Mecak A

更新日期：2019-02-01 00:00:00

abstract：:The structure and integrity of the mitochondrial compartment are features essential for it to function efficiently. The maintenance of mitochondrial structure in cells ranging from yeast to humans has been shown to require both ongoing fission and fusion. Recent characterization of many of the molecular components tha...

journal_title：Current opinion in cell biology

authors： Scott SV,Cassidy-Stone A,Meeusen SL,Nunnari J

更新日期：2003-08-01 00:00:00

abstract：:Recent advances in our understanding of transcription factors that regulate RNA polymerase II transcribed genes are described. This review considers the role of alternate protein-protein interactions to yield positive or negative regulation, the consequences of deregulated factor activity on cell function and approach...

journal_title：Current opinion in cell biology

authors： Morimoto RI

更新日期：1992-06-01 00:00:00

abstract：:Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail. The cilium is assembled from mature (mother) centr...

journal_title：Current opinion in cell biology

authors： Kim S,Dynlacht BD

更新日期：2013-08-01 00:00:00

abstract：:Centrioles are essential microtubule-based organelles, typically present in pairs, which organize cilia and centrosomes. Their mode of biogenesis is unique for a subcellular organelle since, during cell division, each pre-existing centriole guides the formation of a new one, a process that is coordinated with DNA repl...

journal_title：Current opinion in cell biology

authors： Meunier A,Spassky N

更新日期：2016-02-01 00:00:00

abstract：:Neural induction is the process by which embryonic cells in the ectoderm make a decision to acquire a neural fate (to form the neural plate) rather than give rise to other structures such as epidermis or mesoderm. An influential model proposed a decade ago, the 'default model', postulated that ectodermal cells will be...

journal_title：Current opinion in cell biology

authors： Stern CD

更新日期：2006-12-01 00:00:00

abstract：:Myosins are a large family of structurally diverse mechanoenzymes which, upon interaction with actin filaments, convert energy from ATP hydrolysis into mechanical force. Consistent with the ubiquitous association of actin with membranes, many of these novel myosins are membrane-associated. In the past two years, evide...

journal_title：Current opinion in cell biology

authors： Hasson T,Mooseker MS

更新日期：1995-08-01 00:00:00

abstract：:Cell-cell signalling is an essential process in the formation of multicellular organisms. Notch is the receptor of an evolutionarily conserved signalling pathway regulating numerous developmental decisions. Indeed, its misregulation is linked to multiple developmental and physiological disorders. Notch and its ligands...

journal_title：Current opinion in cell biology

authors： Le Borgne R

更新日期：2006-04-01 00:00:00

abstract：:Polarising a cell or an embryo is a crucial and recurrent event during development, as it is important for cell differentiation and migration. Cells can become polarised along their apical-basal axis and also within the plane of the tissue layer to which they belong. The embryo develops three axes: the anteroposterior...

journal_title：Current opinion in cell biology

authors： Wedlich D

更新日期：2002-10-01 00:00:00

abstract：:Mitochondria are highly dynamic organelles that constantly fuse and divide. Dynamin-related GTPases are the core components of the machineries that mediate mitochondrial fusion and fission. The role and regulation of these machineries are currently under intense investigation. Recently, members of the BCL2 family of p...

journal_title：Current opinion in cell biology

authors： Rolland SG,Conradt B

更新日期：2010-12-01 00:00:00

abstract：:Secretion of proteins across the bacterial outer membrane takes place via a variety of mechanisms from simple one-component systems to complex multicomponent pathways. Secretion pathways can be organized into evolutionarily and functionally related groups, which highlight their relationship with organelle biogenesis. ...

journal_title：Current opinion in cell biology

authors： Thanassi DG,Hultgren SJ

更新日期：2000-08-01 00:00:00

abstract：:Transport of newly synthesized material from the endoplasmic reticulum (ER) towards the Golgi complex, through the Golgi cisternae, and out of the trans-Golgi network (TGN) is thought to be mediated by vesicular carriers. Different types of vesicle are involved in this biosynthetic membrane traffic. All are coated wit...

journal_title：Current opinion in cell biology

authors： Kreis TE,Pepperkok R

更新日期：1994-08-01 00:00:00

abstract：:Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown that PcG mechanisms control a large number of genes regulating many cellular functions and all developmental pathways. Cur...

journal_title：Current opinion in cell biology

authors： Schwartz YB,Pirrotta V

更新日期：2008-06-01 00:00:00

abstract：:Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic network that through interactions with all vital cell structures, provides an effective mechanochemical integrator of morphology and function, absolutely necessary for intra-cellular and intercellular coordination of all muscle fun...

journal_title：Current opinion in cell biology

authors： Capetanaki Y,Papathanasiou S,Diokmetzidou A,Vatsellas G,Tsikitis M

更新日期：2015-02-01 00:00:00

abstract：:The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings...

journal_title：Current opinion in cell biology

authors： Phua SC,Nihongaki Y,Inoue T

更新日期：2018-02-01 00:00:00

abstract：:Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial cont...

journal_title：Current opinion in cell biology

authors： Harper CS,White AJ,Lackner LL

更新日期：2020-08-01 00:00:00

abstract：:The cell biologist's insight into endosomal diversity, in terms of both form and function, has increased dramatically in the past few years. This understanding has been promoted by the availability of powerful new techniques that allow imaging of both cargo and machinery in the endocytic process in real time, and by o...

journal_title：Current opinion in cell biology

authors： Perret E,Lakkaraju A,Deborde S,Schreiner R,Rodriguez-Boulan E

更新日期：2005-08-01 00:00:00

abstract：:Classical heterochromatin chromosomal landmarks, such as centromeres and telomeres, are characterized by specific chromatin signatures. Among these, the incorporation of histone variants has recently emerged as an important feature. Using the centromere as a paradigm, we consider the role of histone variant dynamics i...

journal_title：Current opinion in cell biology

authors： Boyarchuk E,Montes de Oca R,Almouzni G

更新日期：2011-06-01 00:00:00

abstract：:As a key part of the mechanism which controls growth and division, cells are able to respond to a variety of intracellular and extracellular stimuli. Significant progress has been made in the understanding of the biochemical mechanisms underlying mating-factor signal transduction in Saccharomyces cerevisiae. Some of t...

journal_title：Current opinion in cell biology

authors： Oehlen B,Cross FR

更新日期：1994-12-01 00:00:00

abstract：:Living cells must be able to switch between growth and differentiation with high fidelity and precise spatial control to ensure that normal tissue patterns are formed in the embryo and maintained throughout adult life. Most work on cell proliferation focuses on elucidating the signaling pathways responsible for contro...

journal_title：Current opinion in cell biology

authors： Mammoto A,Ingber DE

更新日期：2009-12-01 00:00:00

abstract：:The cerebral cortex is composed of hundreds of different types of neurons, which underlie its ability to perform highly complex neural processes. How cortical neurons are generated during development constitutes a major challenge in developmental neurosciences with important implications for brain repair and diseases....

journal_title：Current opinion in cell biology

authors： Tiberi L,Vanderhaeghen P,van den Ameele J

更新日期：2012-04-01 00:00:00

abstract：:The initiation of chromosomal DNA replication involves initiator proteins that recruit and load hexameric DNA helicases at replication origins. This helicase loading step is tightly regulated in bacteria and eukaryotes. In contrast to the situation in bacteria, the eukaryotic helicase is loaded in an inactive form. Th...

journal_title：Current opinion in cell biology

authors： Remus D,Diffley JF

更新日期：2009-12-01 00:00:00