Abstract：
:The establishment of left-right asymmetry during development of vertebrate embryos depends on leftward flow in the nodal cavity. The flow is produced by the rotational movement of the posteriorly tilted nodal cilia. However, it remains poorly understood how the nodal cilia are tilted posteriorly, and how the directionality of the flow is translated into gene expression patterns in the embryo. Recent studies have identified signaling molecules involved in these processes. First, planar cell polarity signaling has been shown to be involved in the posterior positioning of the basal bodies of nodal cilia, which leads to the posterior tilting of their rotation axes. Second, identification of putative receptors and signaling molecules suggests a link between the signaling molecules delivered by the nodal flow, and downstream signaling in the cells surrounding the nodal cavity and the lateral plate mesoderm.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Hirokawa N,Tanaka Y,Okada Ydoi
10.1016/j.ceb.2012.01.002subject
Has Abstractpub_date
2012-02-01 00:00:00pages
31-9issue
1eissn
0955-0674issn
1879-0410pii
S0955-0674(12)00003-8journal_volume
24pub_type
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