Abstract：
:As the largest and stiffest organelle in the cell, the nucleus can be subjected to significant forces generated by the cytoskeleton to adjust its shape and position, and accommodate the cellular machinery during cell migration, differentiation or division. As it was anticipated, recent work showed that mechanosensitive mechanisms exist in the nucleus and regulate its structure and function in response to mechanical force. While the molecular mechanisms that mediate this response are only beginning to be elucidated, the nuclear envelope seems to play a central role in this process. Here, we review these nuclear mechanosensitive mechanisms and highlight their functional homology with those located at the cell surface. Additionally, we discuss how these nuclear envelope mechanisms function during adhesion and migration, and how they participate in cytoskeletal organization, via direct physical contact or signaling event regulation.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Aureille J,Belaadi N,Guilluy Cdoi
10.1016/j.ceb.2016.10.003subject
Has Abstractpub_date
2017-02-01 00:00:00pages
59-67eissn
0955-0674issn
1879-0410pii
S0955-0674(16)30171-5journal_volume
44pub_type
杂志文章,评审abstract：:In the adult, angiogenesis, the formation of new blood vessels from pre-existing vasculature contributes to the pathogenesis of many disorders including cancer. The role of adhesion molecules, especially integrins, in pathological angiogenesis has long been the subject of investigation, mostly because of their potenti...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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abstract：:Piwi-interacting RNAs (piRNAs) were reported in 2006 as a novel class of small non-coding RNAs associated with Piwi proteins of the Argonaute/Piwi family. Recent studies have revealed not only the biogenesis of piRNAs and their roles in transposon silencing, but also the function of the Piwi-piRNA pathway in epigeneti...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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abstract：:The advent of green fluorescent protein technology, its use in photobleaching experiments and the development of methods to rapidly acquire images and analyze complex datasets have opened the door to unraveling the mechanisms of nuclear functions in living cells. Studies over the past few years have characterized the ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：1991-12-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2004.07.014
更新日期：2004-10-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.04.008
更新日期：2020-10-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2015.01.003
更新日期：2015-02-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2014.06.006
更新日期：2014-12-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2015.10.005
更新日期：2015-12-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.04.002
更新日期：2020-08-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2009.08.002
更新日期：2009-12-01 00:00:00
abstract：:There are, in theory, several ways in which proteins may pass through the Golgi apparatus. Among these, the cisternal progression-maturation mode has gained broad consensus. However, there remain questions regarding the molecular mechanisms by which resident proteins are sorted from cargo and move backward to the prox...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2010.05.003
更新日期：2010-08-01 00:00:00
abstract：:The principal subunits of a large superfamily of plasma-membrane cation channels are functionally autonomous in ion conductance and in gating by membrane potential and intracellular ligands. Recent work has located the structural elements responsible for the ion conductance and gating of these channels. These studies ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.05.002
更新日期：2020-10-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.12.007
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.07.002
更新日期：2013-12-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00268-4
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2016.04.001
更新日期：2016-10-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2012.10.019
更新日期：2013-02-01 00:00:00
abstract：:Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail. The cilium is assembled from mature (mother) centr...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.04.011
更新日期：2013-08-01 00:00:00
abstract：:The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2009.03.006
更新日期：2009-06-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.05.008
更新日期：2013-10-01 00:00:00
abstract：:The processes of dying are as tightly regulated as those of growth and proliferation, and together they establish a finely tuned balance that ensures proper organ size and function. Failure in the regulation of these responses lies at the heart of many human diseases. Certain members of the inhibitor of apoptosis (IAP...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2010.08.025
更新日期：2010-12-01 00:00:00
