Abstract:
:This review discusses recent advances in our understanding of adhesion receptor trafficking in vitro, and extrapolates them as far as what is currently possible towards an understanding of migration in three dimensions in vivo. Our specific focus is the mechanisms for endocytosis and recycling of the two major classes of cell-matrix adhesion receptors, integrins and syndecans. We review the signalling networks that are employed to regulate trafficking and conversely the effects of trafficking on signalling itself. We then define the contribution that this element of the migration process makes to processes such as wound healing and tumour invasion.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Jacquemet G,Humphries MJ,Caswell PTdoi
10.1016/j.ceb.2013.05.008subject
Has Abstractpub_date
2013-10-01 00:00:00pages
627-32issue
5eissn
0955-0674issn
1879-0410pii
S0955-0674(13)00082-3journal_volume
25pub_type
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