The structure of the F-actin filament and the actin molecule.

abstract：:Organelles of the central membrane system of higher eukaryotes have been shown to utilize microtubules both for maintenance of their characteristic spatial distributions and for efficient transport of their protein and lipid to diverse sites within the cell. Recent work addressing the mechanisms that underlie this org...

journal_title：Current opinion in cell biology

authors： Cole NB,Lippincott-Schwartz J

更新日期：1995-02-01 00:00:00

abstract：:The mitotic spindle assembly and chromosome segregation in eukaryotes must be coordinated with the nuclear envelope (NE) remodeling. In a so-called 'open' mitosis the envelope of the mother nucleus is dismantled allowing the cytoplasmic spindle microtubules to capture the chromosomes. Alternatively, cells undergoing '...

journal_title：Current opinion in cell biology

authors： Zhang D,Oliferenko S

更新日期：2013-02-01 00:00:00

abstract：:Intracellular signals are received and generated by the alpha(IIb)beta(3) integrin on platelets. Recent advances have been made in the areas of agonist receptors that initiate platelet activation, downstream signaling molecules (e.g. small G-proteins and kinases) and changes in ligand-occupied alpha(IIb)beta(3) that c...

journal_title：Current opinion in cell biology

authors： Parise LV

更新日期：1999-10-01 00:00:00

abstract：:In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two...

journal_title：Current opinion in cell biology

authors： Ohi R,Gould KL

更新日期：1999-04-01 00:00:00

abstract：:AB toxins deliver their enzymatically active A domain to the cytosol. Some AB-toxins are able to penetrate cellular membranes from endosomes where the low pH triggers their translocation. One such toxin is diphtheria toxin and important features of its translocation mechanism have been unraveled during the last year. ...

journal_title：Current opinion in cell biology

authors： Falnes PO,Sandvig K

更新日期：2000-08-01 00:00:00

abstract：:Cohesin, one of structural maintenance of chromosomes (SMC) complexes, forms a ring-shaped protein complex, and mediates sister chromatid cohesion for accurate chromosome segregation and precise genome inheritance. The cohesin ring entraps one or two DNA molecules to achieve cohesion, which is further regulated by coh...

journal_title：Current opinion in cell biology

authors： Nishiyama T

更新日期：2019-06-01 00:00:00

abstract：:There are, in theory, several ways in which proteins may pass through the Golgi apparatus. Among these, the cisternal progression-maturation mode has gained broad consensus. However, there remain questions regarding the molecular mechanisms by which resident proteins are sorted from cargo and move backward to the prox...

journal_title：Current opinion in cell biology

authors： Nakano A,Luini A

更新日期：2010-08-01 00:00:00

abstract：:At the time of this writing, searching Google Scholar for 'light-sheet microscopy' returns almost 8500 results; over three-quarters of which were published in the last 5 years alone. Searching for other advanced imaging methods in the last 5 years yields similar results: 'super-resolution microscopy' (>16 000), 'singl...

journal_title：Current opinion in cell biology

authors： Lemon WC,McDole K

更新日期：2020-10-01 00:00:00

abstract：:Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors i...

journal_title：Current opinion in cell biology

authors： Hakes AE,Brand AH

更新日期：2019-10-01 00:00:00

abstract：:Members of the kinesin superfamily of microtubule-based motors and the myosin superfamily of actin-based motors that move 'backwards' have been identified. As the core catalytic domains of myosins and kinesins are similar in structure, this raises the intriguing questions of how direction reversal is accomplished and ...

journal_title：Current opinion in cell biology

authors： Hasson T,Cheney RE

更新日期：2001-02-01 00:00:00

abstract：:Tissue stem cells are found in specialized microenvironments (niches) where they are exposed to diverse systemic and local signals that are integrated with cell intrinsic factors to regulate stem cell behavior. In general, systemic signals are utilized to coordinate the response of tissues to acute or long-term change...

journal_title：Current opinion in cell biology

authors： Resende LP,Jones DL

更新日期：2012-04-01 00:00:00

abstract：:Receptors for the two peroxisomal targeting signals PTS1 and PTS2 have recently been identified in yeasts. The disparate subcellular locations of PTS receptor homologs have led to proposals of receptor shuttling between the cytosol and the peroxisomal membrane, and to the suggestion that some of these molecules may ev...

journal_title：Current opinion in cell biology

authors： Subramani S

更新日期：1996-08-01 00:00:00

abstract：:Acetyl-CoA represents a key node in metabolism due to its intersection with many metabolic pathways and transformations. Emerging evidence reveals that cells monitor the levels of acetyl-CoA as a key indicator of their metabolic state, through distinctive protein acetylation modifications dependent on this metabolite....

journal_title：Current opinion in cell biology

authors： Shi L,Tu BP

更新日期：2015-04-01 00:00:00

abstract：:This review discusses recent advances in our understanding of adhesion receptor trafficking in vitro, and extrapolates them as far as what is currently possible towards an understanding of migration in three dimensions in vivo. Our specific focus is the mechanisms for endocytosis and recycling of the two major classes...

journal_title：Current opinion in cell biology

authors： Jacquemet G,Humphries MJ,Caswell PT

更新日期：2013-10-01 00:00:00

abstract：:Cell migration requires the integration and coordination of specific focal adhesion dynamics at the cell front, center and rear. In this review, we will present our understanding of the regulation of adhesion turnover and disassembly in various regions of the cell. Adhesion turnover involves a number of tyrosine kinas...

journal_title：Current opinion in cell biology

authors： Broussard JA,Webb DJ,Kaverina I

更新日期：2008-02-01 00:00:00

abstract：:Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain their size without...

journal_title：Current opinion in cell biology

authors： Sauls JT,Li D,Jun S

更新日期：2016-02-01 00:00:00

abstract：:The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete in...

journal_title：Current opinion in cell biology

authors： Grünwald D,Singer RH

更新日期：2012-02-01 00:00:00

abstract：:The number and variety of factors underlying control of gene expression have been frequently underestimated. Non-coding RNAs generated through pervasive transcription have recently been implicated in shaping the transcriptional landscape in different organisms from bacteria to higher eukaryotes, adding a previously un...

journal_title：Current opinion in cell biology

authors： Castelnuovo M,Stutz F

更新日期：2015-06-01 00:00:00

abstract：:As a key part of the mechanism which controls growth and division, cells are able to respond to a variety of intracellular and extracellular stimuli. Significant progress has been made in the understanding of the biochemical mechanisms underlying mating-factor signal transduction in Saccharomyces cerevisiae. Some of t...

journal_title：Current opinion in cell biology

authors： Oehlen B,Cross FR

更新日期：1994-12-01 00:00:00

abstract：:Autophagy is a crucial component of the cellular stress adaptation response that maintains mammalian homeostasis. Autophagy protects against neurodegenerative and inflammatory conditions, aging, and cancer. This is accomplished by the degradation and intracellular recycling of cellular components to maintain energy me...

journal_title：Current opinion in cell biology

authors： White E,Karp C,Strohecker AM,Guo Y,Mathew R

更新日期：2010-04-01 00:00:00

abstract：:It has become clear that many vital metabolic circuits and early developmental programs are regulated translationally. Until recently, the mechanisms underlying most of these observations were poorly understood. The past year has witnessed several important advances in the understanding of how the translational appara...

journal_title：Current opinion in cell biology

authors： Hentze MW

更新日期：1995-06-01 00:00:00

abstract：:Centromeres and telomeres are both composed of specific DNA sequences and unique chromosomal proteins. Isolation and characterization of some of these sequences and proteins has greatly increased our knowledge of centromere and telomere structure. This information is allowing us to determine how centromeres and telome...

journal_title：Current opinion in cell biology

authors： Price CM

更新日期：1992-06-01 00:00:00

abstract：:Studies of yeast transcription factors have contributed greatly to understanding basic molecular mechanisms of eukaryotic gene regulation, largely due to powerful genetic approaches that are unavailable in other organisms. The broad outlines of these mechanisms are fairly well understood, and there is an increasing nu...

journal_title：Current opinion in cell biology

authors： Struhl K

更新日期：1993-06-01 00:00:00

abstract：:Cell surface molecules, ligands, and solutes can be endocytosed into animal cells via several pathways in addition to clathrin-mediated endocytosis, which all seem to lead to canonical endosomes. It seems that viruses can enter and infect cells through most of, if not all, endocytic routes, having evolved different, s...

journal_title：Current opinion in cell biology

authors： Gruenberg J

更新日期：2009-08-01 00:00:00

abstract：:Neural induction is the process by which embryonic cells in the ectoderm make a decision to acquire a neural fate (to form the neural plate) rather than give rise to other structures such as epidermis or mesoderm. An influential model proposed a decade ago, the 'default model', postulated that ectodermal cells will be...

journal_title：Current opinion in cell biology

authors： Stern CD

更新日期：2006-12-01 00:00:00

abstract：:The relationship between cell growth (cell mass increase over time) and cell division is poorly understood in animal stem cells. Recent studies in several Drosophila stem cell types have provided the tools to interrogate this relationship. In several cases (brat, mei-P26, pros, bam, lethal giant larvae, polo), mutatio...

journal_title：Current opinion in cell biology

authors： Kohlmaier A,Edgar BA

更新日期：2008-12-01 00:00:00

abstract：:Cohesin is a four subunit complex, conserved from yeast to man, with the ability to hold together two DNA segments within its ring-shaped structure. When the two segments belong to sister chromatids, cohesin is mediating cohesion, which is essential for chromosome segregation in mitosis and meiosis and for homologous ...

journal_title：Current opinion in cell biology

authors： Remeseiro S,Losada A

更新日期：2013-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid and glucose homeostasis, inflammation and wound healing. In addition to ligand binding, phosphorylation can also regulate PPARs; the biological effects of phosphorylation depend on the stimulus, the kinase, the PPAR isotype, th...

journal_title：Current opinion in cell biology

authors： Gelman L,Michalik L,Desvergne B,Wahli W

更新日期：2005-04-01 00:00:00

abstract：:Several GPCRs, including receptors previously thought to signal primarily from the cell surface, have been recently shown to signal from many intracellular compartments. This raises the idea that signaling by any given receptor is spatially encoded in the cell, with distinct sites of signal origin dictating distinct d...

journal_title：Current opinion in cell biology

authors： Weinberg ZY,Crilly SE,Puthenveedu MA

更新日期：2019-04-01 00:00:00

abstract：:Mammalian cell biology is witnessing a new era in which cellular processes are explained through dynamic networks of interacting cellular components. In this fast-pacing field, where image-based RNAi screening is taking a central role, there is a strong need to improve ways to capture such interactions in space and ti...

journal_title：Current opinion in cell biology

authors： Sacher R,Stergiou L,Pelkmans L

更新日期：2008-08-01 00:00:00