Abstract:
:Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors in the brain suggests there are many potential routes to tumour initiation. Studies in Drosophila melanogaster have enhanced our understanding of the tumourigenic potential of distinct cell types in the brain. Here we review recent studies that have improved our knowledge of neural stem cell behaviour during development and in brain tumour models.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Hakes AE,Brand AHdoi
10.1016/j.ceb.2019.06.001subject
Has Abstractpub_date
2019-10-01 00:00:00pages
131-138eissn
0955-0674issn
1879-0410pii
S0955-0674(19)30052-3journal_volume
60pub_type
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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