Abstract:
:The Golgi apparatus occupies a central position within the secretory pathway where it is a hub for vesicle trafficking. Distinct classes of transport vesicles traffic diverse cargoes into and out of this organelle, as well as between the different Golgi subcompartments. A key feature of Golgi trafficking is the specific recognition of transport vesicles at the different regions of the Golgi apparatus, required for the correct cargo delivery. Specificity is ensured by coiled-coil golgins and multi-subunit tethering complexes (MTCs), which act together to capture vesicles and promote their subsequent fusion with the Golgi membrane. In this review we discuss our current understanding of how golgins and MTCs function together to mediate the specific recognition of vesicles at the Golgi apparatus.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Witkos TM,Lowe Mdoi
10.1016/j.ceb.2017.02.003subject
Has Abstractpub_date
2017-08-01 00:00:00pages
16-23eissn
0955-0674issn
1879-0410pii
S0955-0674(17)30012-1journal_volume
47pub_type
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