Abstract:
:Chromosome segregation during mitosis is mediated by the mitotic spindle, a structure composed of microtubules associated with a variety of proteins. Additionally, a distinct biochemical milieu, the 'spindle matrix', has long been proposed to assist this process and recent work provided compelling evidence for its existence in living animal cells. Here we focus on the dynamic properties of such a matrix, highlighting its roles in the spatial and temporal control of mitotic fidelity in respect to recent findings in different systems. Based on these findings and on theoretical principles behind molecular crowding, we challenge the idea of the spindle matrix as one functional entity and propose that some observed phenomena associated with this elusive structure could simply be a consequence of intrinsic cellular architecture and cytoplasmic 'compartmentalization' during mitosis.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Schweizer N,Weiss M,Maiato Hdoi
10.1016/j.ceb.2014.01.002subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1-7eissn
0955-0674issn
1879-0410pii
S0955-0674(14)00003-9journal_volume
28pub_type
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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