Canonical and noncanonical functions of ULK/Atg1.

abstract：:Golgins are a family of coiled-coil proteins associated with the Golgi apparatus necessary for tethering events in membrane fusion and as structural supports for Golgi cisternae. Recent work has shown that golgins such as GM130, golgin-45 and p115 bind to Rab GTPases via their coiled-coil domains, and that GM130, rath...

journal_title：Current opinion in cell biology

authors： Barr FA,Short B

更新日期：2003-08-01 00:00:00

abstract：:A major current issue in vesicle trafficking is whether NSF (N-ethylmaleimide-sensitive factor) and alpha-SNAP (alpha-soluble NSF attachment protein) are required prior to SNARE (SNAP receptor) complex formation to allow vesicle docking, or after docking at a step close to membrane fusion. Recent studies of yeast vacu...

journal_title：Current opinion in cell biology

authors： Hay JC,Scheller RH

更新日期：1997-08-01 00:00:00

abstract：:One of the most notable trends in human evolution is the dramatic increase in brain size that has occurred in the great ape clade, culminating in humans. Of particular interest is the vast expanse of the cerebral cortex, which is believed to have resulted in our ability to perform higher cognitive functions. Recent in...

journal_title：Current opinion in cell biology

authors： Bond J,Woods CG

更新日期：2006-02-01 00:00:00

abstract：:Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism...

journal_title：Current opinion in cell biology

authors： Anastasiadis PZ,Reynolds AB

更新日期：2001-10-01 00:00:00

abstract：:How are cell morphogenesis and cell cycle coordinated? The fission yeast is a rod-shaped unicellular organism widely used to study how a cell self-organizes in space and time. Here, we discuss recent advances in understanding how the cell acquires and maintains its regular rod shape and uses it to control cell divisio...

journal_title：Current opinion in cell biology

authors： Hachet O,Bendezú FO,Martin SG

更新日期：2012-12-01 00:00:00

abstract：:Centromeres and telomeres are both composed of specific DNA sequences and unique chromosomal proteins. Isolation and characterization of some of these sequences and proteins has greatly increased our knowledge of centromere and telomere structure. This information is allowing us to determine how centromeres and telome...

journal_title：Current opinion in cell biology

authors： Price CM

更新日期：1992-06-01 00:00:00

abstract：:Cellular asymmetries have been proposed to play a role in plant embryogenesis. Genetic studies of Arabidopsis and other experimental approaches in several plant species have addressed the origins of cellular asymmetry in specific cases. Although zygote polarity, which precedes the formation of the apical-basal axis of...

journal_title：Current opinion in cell biology

authors： Jürgens G,Grebe M,Steinmann T

更新日期：1997-12-01 00:00:00

abstract：:Actin polymerization generates the force that deforms the cell membrane, pulls the cell forward and propels endosomes and bacteria within the cell. The mechanism of force generation has been probed using experimental biomimetic systems where force generation and movement occur by the same actin-polymerization processe...

journal_title：Current opinion in cell biology

authors： Plastino J,Sykes C

更新日期：2005-02-01 00:00:00

abstract：:Regulation of skeletal muscle determination and differentiation in vertebrates centers on a core regulatory network which is composed of two families of transcription factors, the MyoD group basic helix-loop-helix (bHLH) muscle regulatory factors (MRFs) and the myocyte enhancer factor 2 (MEF2) group of MADS-box regula...

journal_title：Current opinion in cell biology

authors： Yun K,Wold B

更新日期：1996-12-01 00:00:00

abstract：:Apoptosis, or programmed cell death, plays an essential role in specific cell deletion during normal embryonic and adult development in vertebrate and invertebrate species. Recent evidence suggests that signal transduction pathways governing cellular proliferation and cell cycle progression also mediate the physiologi...

journal_title：Current opinion in cell biology

authors： Lee S,Christakos S,Small MB

更新日期：1993-04-01 00:00:00

abstract：:Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and membranes. Innate immune cells and transformed cancer cells share the capacity for both constitutive and induced macropinocytosis, which...

journal_title：Current opinion in cell biology

authors： Stow JL,Hung Y,Wall AA

更新日期：2020-08-01 00:00:00

abstract：:Most cancers arise in epithelia, the tissue type that lines all body cavities. The organization of epithelia enables them to act as a barrier and perform vectorial transport of molecules between body compartments. Crucial for their organization and function is a highly specialized network of cell adhesion and polarity...

journal_title：Current opinion in cell biology

authors： Hinck L,Näthke I

更新日期：2014-02-01 00:00:00

abstract：:Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy bala...

journal_title：Current opinion in cell biology

authors： Wu Z,Puigserver P,Spiegelman BM

更新日期：1999-12-01 00:00:00

abstract：:Research over the past two decades has defined a window of time in the early/mid G1 phase of the cell cycle during which mammalian cells are responsive to extracellular signals. Recent evidence indicates that this period ends with the phosphorylation of the retinoblastoma protein, enabling the cells to pass through th...

journal_title：Current opinion in cell biology

authors： Planas-Silva MD,Weinberg RA

更新日期：1997-12-01 00:00:00

abstract：:Telomeres, the natural termini of eukaryotic chromosomes, have been the subject of intense interest during the last decade because of the roles that these chromosome termini perform in both cancer and aging. As we become more cognizant of the consequences of telomere dysfunction on several aspects of human health, sig...

journal_title：Current opinion in cell biology

authors： Bertuch AA,Lundblad V

更新日期：2006-06-01 00:00:00

abstract：:Germline stem cells (GSCs) sustain gametogenesis during the life of organisms. Recent progress has substantially extended our understanding of GSC behavior, including the mechanisms of stem cell self-renewal, asymmetric stem cell division, stem cell niches, dedifferentiation, and tissue aging. GSCs typically are highl...

journal_title：Current opinion in cell biology

authors： Yuan H,Yamashita YM

更新日期：2010-12-01 00:00:00

abstract：:Several lines of evidence indicate that the lipids in the plasma membrane of animal cells are inhomogeneously distributed, and that various types of specialized lipid domains play an important role in many biological processes. The characteristics of these domains, such as size, composition and dynamics, are currently...

journal_title：Current opinion in cell biology

authors： Maxfield FR

更新日期：2002-08-01 00:00:00

abstract：:Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold o...

journal_title：Current opinion in cell biology

authors： Fernandez-Martinez J,Rout MP

更新日期：2009-08-01 00:00:00

abstract：:Integrins are heterodimeric transmembrane receptors that connect the extracellular matrix environment to the actin cytoskeleton via adaptor molecules through assembly of a range of adhesion structures. Recent advances in biochemical, imaging and biophysical methods have enabled a deeper understanding of integrin signa...

journal_title：Current opinion in cell biology

authors： Michael M,Parsons M

更新日期：2020-04-01 00:00:00

abstract：:Particle engulfment during phagocytosis has long been appreciated to be an active, actin-driven process. By contrast, the preceding stage--securing the target to the surface of the phagocyte--was thought to result from the passive diffusion of receptors along the membrane towards their ligands on the particle surface....

journal_title：Current opinion in cell biology

authors： Jaumouillé V,Grinstein S

更新日期：2011-02-01 00:00:00

abstract：:This past year has seen a significant increase in our understanding of eukaryotic origins of replication, of the proteins that identify these origins, of DNA sequences that promote their unwinding, and of transcription factors that stimulate origin activity. DNA replication begins at specific sites in both simple and ...

journal_title：Current opinion in cell biology

authors： DePamphilis ML

更新日期：1993-06-01 00:00:00

abstract：:The actin supergene family encodes a number of structurally related, but perhaps functionally distinct, protein isoforms that regulate contractile potential in muscle tissues and help to control the shape as well as the motility of non-muscle cells. In spite of the documented conservation amongst isoactin genes and th...

journal_title：Current opinion in cell biology

authors： Herman IM

更新日期：1993-02-01 00:00:00

abstract：:A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of...

journal_title：Current opinion in cell biology

authors： Gruenberg J,Clague MJ

更新日期：1992-08-01 00:00:00

abstract：:At the time of this writing, searching Google Scholar for 'light-sheet microscopy' returns almost 8500 results; over three-quarters of which were published in the last 5 years alone. Searching for other advanced imaging methods in the last 5 years yields similar results: 'super-resolution microscopy' (>16 000), 'singl...

journal_title：Current opinion in cell biology

authors： Lemon WC,McDole K

更新日期：2020-10-01 00:00:00

abstract：:A consensus view on the three-dimensional structure of the F-actin filament and the relative strength of the intersubunit contacts in the filament has been established from an atomic filament model and recent three-dimensional reconstructions from electron micrographs of F-actin filaments. Functional implications of r...

journal_title：Current opinion in cell biology

authors： Bremer A,Aebi U

更新日期：1992-02-01 00:00:00

abstract：:A defining feature of eukaryotic cells is the nucleus, which houses the genome inside the nuclear envelope (NE): a double lipid bilayer that separates the nuclear and cytoplasmic materials. Although the NE is commonly viewed as a barrier that is overcome only by embedded nuclear pore complexes (NPCs) that facilitate n...

journal_title：Current opinion in cell biology

authors： Smoyer CJ,Jaspersen SL

更新日期：2014-02-01 00:00:00

abstract：:Neural induction is the process by which embryonic cells in the ectoderm make a decision to acquire a neural fate (to form the neural plate) rather than give rise to other structures such as epidermis or mesoderm. An influential model proposed a decade ago, the 'default model', postulated that ectodermal cells will be...

journal_title：Current opinion in cell biology

authors： Stern CD

更新日期：2006-12-01 00:00:00

abstract：:A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hier...

journal_title：Current opinion in cell biology

authors： Roskelley CD,Srebrow A,Bissell MJ

更新日期：1995-10-01 00:00:00

abstract：:Several recently discovered mammalian cell adhesion proteins recognize and bind to sialic acid-containing ligands. Reports concerning the molecular specificities of these interactions have been intriguing but somewhat confusing, partly because of pitfalls in methodology or interpretation. Nevertheless, these protein-c...

journal_title：Current opinion in cell biology

authors： Varki A

更新日期：1992-04-01 00:00:00

abstract：:Primordial germ cells (PGCs), the progenitors of the gametes, migrate from the position where they are specified towards the region where the gonad develops. To reach their target, the PGCs obtain directional cues from cells positioned along their migration path. One such cue, the chemokine SDF-1, has recently been fo...

journal_title：Current opinion in cell biology

authors： Raz E

更新日期：2004-04-01 00:00:00