Abstract：
:Apoptosis, or programmed cell death, plays an essential role in specific cell deletion during normal embryonic and adult development in vertebrate and invertebrate species. Recent evidence suggests that signal transduction pathways governing cellular proliferation and cell cycle progression also mediate the physiological response to changes in the extracellular environment that trigger the anti-proliferative state characteristic of apoptosis.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Lee S,Christakos S,Small MBdoi
10.1016/0955-0674(93)90118-asubject
Has Abstractpub_date
1993-04-01 00:00:00pages
286-91issue
2eissn
0955-0674issn
1879-0410pii
0955-0674(93)90118-Ajournal_volume
5pub_type
杂志文章,评审abstract：:One of the most notable trends in human evolution is the dramatic increase in brain size that has occurred in the great ape clade, culminating in humans. Of particular interest is the vast expanse of the cerebral cortex, which is believed to have resulted in our ability to perform higher cognitive functions. Recent in...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2005.11.004
更新日期：2006-02-01 00:00:00
abstract：:Peroxisomes are part of the ubiquitous set of eukaryotic organelles. They are small, single membrane bounded vesicles, specialized in the degradation of very-long-chain fatty acids and in synthesis of myelin lipids. Once considered inconspicuous, recent new insights in the formation and function of peroxisomes have re...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.05.004
更新日期：2013-08-01 00:00:00
abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2016.04.001
更新日期：2016-10-01 00:00:00
abstract：:The relationship between cell growth (cell mass increase over time) and cell division is poorly understood in animal stem cells. Recent studies in several Drosophila stem cell types have provided the tools to interrogate this relationship. In several cases (brat, mei-P26, pros, bam, lethal giant larvae, polo), mutatio...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2008.10.002
更新日期：2008-12-01 00:00:00
abstract：:Cilia (and flagella) are microtubule-based protrusions that are found in single or multiple copies on the surface of most eukaryotic cells. Defects in cilia formation and/or function have now been correlated with an expanding spectrum of human genetic diseases termed ciliopathies. Recent work indicates that cilia are ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2016.05.004
更新日期：2016-08-01 00:00:00
abstract：:The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokine...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00132-0
更新日期：2000-10-01 00:00:00
abstract：:In the past decade, studies into the way in which intracellular bacterial pathogens hijack and subvert their hosts have provided many important insights into regulation of the actin cytoskeleton and cell motility, in addition to increasing our understanding of the infection process. Viral pathogens, however, may ultim...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00180-0
更新日期：2001-02-01 00:00:00
abstract：:A key difference between yeast and metazoans is the need of the latter to regulate cell proliferation and growth to create organs (and organisms) of reproducible size and shape. Great progress has been made in understanding how growth, cell size and the cell cycle are controlled in metazoans. Recent work has shown tha...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2005.09.008
更新日期：2005-12-01 00:00:00
abstract：:Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors i...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2019.06.001
更新日期：2019-10-01 00:00:00
abstract：:Recent advances in understanding spatial genome organization inside the nucleus have shown that chromatin is compartmentalized into megabase-scale units known as topologically associating domains (TADs). In further studies, TADs were linked to differing transcriptional activity, suggesting that they might provide a sc...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2020.01.003
更新日期：2020-06-01 00:00:00
abstract：:The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2010.08.021
更新日期：2010-12-01 00:00:00
abstract：:A major goal in cell biology is to understand the functional organization of macromolecular complexes in vivo. Electron microscopy is helping cell biologists to achieve this goal, thanks to its ability to resolve structural details in the nanometer range. While issues related to specimen preparation, imaging, and imag...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2008.12.003
更新日期：2009-02-01 00:00:00
abstract：:Despite some recent setbacks, it remains clear that adult stem cells under appropriate experimental conditions can at some frequency exhibit a wider range of differentiation potentials than previously appreciated. This is underscored by the recent demonstration of the extensive differentiation potential of mesenchymal...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(02)00392-7
更新日期：2002-12-01 00:00:00
abstract：:Cell adhesion occurs via a highly regulated set of sequential interactions. Prototypic components of a variety of adhesion cascades are discussed, including integrins, triggering molecules and lectin-carbohydrate interactions. Selectivity and efficiency are achieved by utilizing the right combination of multiple adhes...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(92)90106-m
更新日期：1992-10-01 00:00:00
abstract：:The advent of green fluorescent protein technology, its use in photobleaching experiments and the development of methods to rapidly acquire images and analyze complex datasets have opened the door to unraveling the mechanisms of nuclear functions in living cells. Studies over the past few years have characterized the ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(03)00012-7
更新日期：2003-04-01 00:00:00
abstract：:Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by GEFs (guanine nucleotide exchange factors) and then inactivated by GAPs (GTPase activating proteins). Recent evidence shows that in addition to activati...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2019.03.004
更新日期：2019-08-01 00:00:00
abstract：:Asymmetric cell division (ACD) is the fundamental process through which one cell divides into two cells with different fates. In animals, it is crucial for the generation of cell-type diversity and for stem cells, which use ACD both to self-renew and produce one differentiating daughter cell. One of the most prominent...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2019.07.018
更新日期：2020-02-01 00:00:00
abstract：:The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are un...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/S0955-0674(99)80050-7
更新日期：1999-06-01 00:00:00
abstract：:Commitment to division requires that cells sense, interpret, and respond appropriately to multiple signals. In most eukaryotes, cells commit to division in G1 before DNA replication. Beyond a point, known as Start in yeast and the restriction point in mammals, cells will proceed through the cell cycle despite changes ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2013.07.010
更新日期：2013-12-01 00:00:00
abstract：:Golgins are a family of coiled-coil proteins associated with the Golgi apparatus necessary for tethering events in membrane fusion and as structural supports for Golgi cisternae. Recent work has shown that golgins such as GM130, golgin-45 and p115 bind to Rab GTPases via their coiled-coil domains, and that GM130, rath...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(03)00054-1
更新日期：2003-08-01 00:00:00
abstract：:The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete in...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2011.11.011
更新日期：2012-02-01 00:00:00
abstract：:Microtubule self-assembly dynamics serve to facilitate many vital cellular functions, such as chromosome segregation during mitosis and synaptic plasticity. However, the detailed atomistic basis of assembly dynamics has remained an unresolved puzzle. A key challenge is connecting together the vast range of relevant le...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2017.12.013
更新日期：2018-02-01 00:00:00
abstract：:A fusion of mouse and human genetics has now proven that intermediate filaments form a flexible scaffold essential for structuring cytoplasm in a variety of cell contexts. In some cases, the formation of this scaffold is achieved through a newly identified family of intermediate-filament-associated proteins that form ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(98)80091-4
更新日期：1998-02-01 00:00:00
abstract：:Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the alpha-subunits of G proteins as the pathway for downstream regulation, very active roles for the beta gamma-subunits have...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(94)90136-8
更新日期：1994-04-01 00:00:00
abstract：:The nucleoskeleton is composed of many interacting structural proteins that provide the framework for DNA replication, transcription and a variety of other nuclear functions. For example, the type-V intermediate filament proteins, the lamins, and their associated proteins (e.g. Lap2alpha) play important roles in DNA r...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(03)00050-4
更新日期：2003-06-01 00:00:00
abstract：:Concomitant with packaging the genome, the cell nucleus must also spatially organize the nucleoplasm. This complex mixture of proteins and nucleic acids partitions into a variety of phase-separated, membraneless organelles called nuclear bodies. Significant progress has been made in understanding the relationship betw...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2017.03.003
更新日期：2017-06-01 00:00:00
abstract：:Chromosome segregation during mitosis is mediated by the mitotic spindle, a structure composed of microtubules associated with a variety of proteins. Additionally, a distinct biochemical milieu, the 'spindle matrix', has long been proposed to assist this process and recent work provided compelling evidence for its exi...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2014.01.002
更新日期：2014-06-01 00:00:00
abstract：:Spatiotemporal Ca2+ signalling in the cytoplasm is currently understood as an excitation phenomenon by analogy with electrical excitation in the plasma membrane. In many cell types, Ca2+ waves and Ca2+ oscillations are mediated by inositol 1,4,5-trisphosphate (IP3) receptor/Ca2+ channels in the endoplasmic reticulum m...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(95)80027-1
更新日期：1995-04-01 00:00:00
abstract：:Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal networks, made of actin filaments, microtubules, and intermediate filaments. These three types of cytoskeletal polymers have rather different structural and physical properties, enabling specific cellular functions. However, there ...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2014.10.005
更新日期：2015-02-01 00:00:00
abstract：:Several proteins involved in exocytosis have been identified recently, but it is still completely unclear which molecules perform the fusion event itself. Although in viral fusion the fusion proteins are known, even there the molecular mechanism remains controversial. Investigation of single fusion events by electroph...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(95)80007-7
更新日期：1995-08-01 00:00:00
