Abstract：
:Commitment to division requires that cells sense, interpret, and respond appropriately to multiple signals. In most eukaryotes, cells commit to division in G1 before DNA replication. Beyond a point, known as Start in yeast and the restriction point in mammals, cells will proceed through the cell cycle despite changes in upstream signals. In metazoans, misregulated G1 control can lead to developmental problems or disease, so it is important to understand how cells decipher the myriad external and internal signals that contribute to the fundamental all-or-none decision to divide. Extensive study of G1 control in the budding yeast Saccharomyces cerevisiae and mammalian culture systems has revealed highly similar networks regulating commitment. However, protein sequences of functional orthologs often indicate a total lack of conservation suggesting significant evolution of G1 control. Here, we review recent studies defining the conserved and diverged features of G1 control and highlight systems-level aspects that may be common to other biological regulatory networks.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Johnson A,Skotheim JMdoi
10.1016/j.ceb.2013.07.010subject
Has Abstractpub_date
2013-12-01 00:00:00pages
717-23issue
6eissn
0955-0674issn
1879-0410pii
S0955-0674(13)00124-5journal_volume
25pub_type
杂志文章,评审abstract：:In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two...
journal_title：Current opinion in cell biology
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更新日期：1999-04-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00212-x
更新日期：2001-06-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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更新日期：2017-08-01 00:00:00
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：1992-04-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：1992-10-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00111-3
更新日期：2000-08-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2016.01.015
更新日期：2016-06-01 00:00:00
abstract：:The Drosophila decapentaplegic gene, the Xenopus activin genes and the genes encoding the mouse bone morphogenetic proteins are transforming growth factor-beta-related genes whose roles in development are the focus of current studies. They exhibit elaborate patterns of expression during development, and the protein pr...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/0955-0674(91)90112-c
更新日期：1991-12-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2011.07.001
更新日期：2011-10-01 00:00:00
abstract：:Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/s0955-0674(00)00258-1
更新日期：2001-10-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：1991-12-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2018.11.006
更新日期：2019-06-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2017.04.006
更新日期：2017-10-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：2002-12-01 00:00:00
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journal_title：Current opinion in cell biology
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更新日期：2003-12-01 00:00:00
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
doi：10.1016/j.ceb.2004.07.014
更新日期：2004-10-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
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journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：2002-10-01 00:00:00
abstract：:Spatiotemporal Ca2+ signalling in the cytoplasm is currently understood as an excitation phenomenon by analogy with electrical excitation in the plasma membrane. In many cell types, Ca2+ waves and Ca2+ oscillations are mediated by inositol 1,4,5-trisphosphate (IP3) receptor/Ca2+ channels in the endoplasmic reticulum m...
journal_title：Current opinion in cell biology
pub_type： 杂志文章,评审
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更新日期：1995-04-01 00:00:00
