Sequence-encoded material properties dictate the structure and function of nuclear bodies.

abstract：:A standout feature of eukaryotic cells is the presence of organelles with distinct chemical compositions and physical properties, which aid in the accomplishment of specialized metabolic tasks. This complex topology, however, makes a permanent crosstalk between the organelles a necessity for the coordination of cellul...

journal_title：Current opinion in cell biology

authors： Lang A,John Peter AT,Kornmann B

更新日期：2015-08-01 00:00:00

abstract：:In the past year, major advances have been made in our understanding of the regulation of phosphoinositidase C, and of the action of the inositol trisphosphate receptor and how it may generate 'quantal' Ca2+ release. The functions of inositol tetrakisphosphate and of the 3-phosphorylated inositol lipids continue to ge...

journal_title：Current opinion in cell biology

authors： Irvine RF

更新日期：1992-04-01 00:00:00

abstract：:Living cells must be able to switch between growth and differentiation with high fidelity and precise spatial control to ensure that normal tissue patterns are formed in the embryo and maintained throughout adult life. Most work on cell proliferation focuses on elucidating the signaling pathways responsible for contro...

journal_title：Current opinion in cell biology

authors： Mammoto A,Ingber DE

更新日期：2009-12-01 00:00:00

abstract：:The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depe...

journal_title：Current opinion in cell biology

authors： Doyle AD,Petrie RJ,Kutys ML,Yamada KM

更新日期：2013-10-01 00:00:00

abstract：:Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression. ...

journal_title：Current opinion in cell biology

authors： Nigg EA

更新日期：1993-04-01 00:00:00

abstract：:Acetyl-CoA represents a key node in metabolism due to its intersection with many metabolic pathways and transformations. Emerging evidence reveals that cells monitor the levels of acetyl-CoA as a key indicator of their metabolic state, through distinctive protein acetylation modifications dependent on this metabolite....

journal_title：Current opinion in cell biology

authors： Shi L,Tu BP

更新日期：2015-04-01 00:00:00

abstract：:The G protein-coupled receptor (GPCR) family is among the most druggable families in the human proteome. GPCRs are involved in most physiological processes, and our ability to modulate their activity is a hallmark of modern pharmacology. The means by which the activity of GPCRs can be modulated have been expanded by e...

journal_title：Current opinion in cell biology

authors： Giguere PM,Kroeze WK,Roth BL

更新日期：2014-04-01 00:00:00

abstract：:Throughout their lifetimes, all cells experience force. These forces are sensed by cell surface adhesion receptors, such as the cadherins and integrins. Much attention has focused on identifying how these adhesion receptors transmit force. In contrast, less is known regarding how these force-activated pathways are int...

journal_title：Current opinion in cell biology

authors： Salvi AM,DeMali KA

更新日期：2018-10-01 00:00:00

abstract：:Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal networks, made of actin filaments, microtubules, and intermediate filaments. These three types of cytoskeletal polymers have rather different structural and physical properties, enabling specific cellular functions. However, there ...

journal_title：Current opinion in cell biology

authors： Huber F,Boire A,López MP,Koenderink GH

更新日期：2015-02-01 00:00:00

abstract：:The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokine...

journal_title：Current opinion in cell biology

authors： Agace WW,Higgins JM,Sadasivan B,Brenner MB,Parker CM

更新日期：2000-10-01 00:00:00

abstract：:A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of...

journal_title：Current opinion in cell biology

authors： Gruenberg J,Clague MJ

更新日期：1992-08-01 00:00:00

abstract：:The structure and integrity of the mitochondrial compartment are features essential for it to function efficiently. The maintenance of mitochondrial structure in cells ranging from yeast to humans has been shown to require both ongoing fission and fusion. Recent characterization of many of the molecular components tha...

journal_title：Current opinion in cell biology

authors： Scott SV,Cassidy-Stone A,Meeusen SL,Nunnari J

更新日期：2003-08-01 00:00:00

abstract：:Mitochondria are classically known as the essential energy producers in cells. As such, the activation of mitochondrial metabolism upon cellular differentiation was deemed a necessity to fuel the high metabolic needs of differentiated cells. However, recent studies have revealed a direct role for mitochondrial activit...

journal_title：Current opinion in cell biology

authors： Khacho M,Slack RS

更新日期：2017-12-01 00:00:00

abstract：:Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail. The cilium is assembled from mature (mother) centr...

journal_title：Current opinion in cell biology

authors： Kim S,Dynlacht BD

更新日期：2013-08-01 00:00:00

abstract：:A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity toward relevant substrates. Recently the structural basis for these protein-protein interactions has ...

journal_title：Current opinion in cell biology

authors： Beene DL,Scott JD

更新日期：2007-04-01 00:00:00

abstract：:The nuclear pore complex (NPC) has long been viewed as a point-like entry and exit channel between the nucleus and the cytoplasm. New data support a different view whereby the complex displays distinct spatial dynamics of variable duration ranging from milliseconds to events spanning the entire cell cycle. Discrete in...

journal_title：Current opinion in cell biology

authors： Grünwald D,Singer RH

更新日期：2012-02-01 00:00:00

abstract：:Intracellular signals are received and generated by the alpha(IIb)beta(3) integrin on platelets. Recent advances have been made in the areas of agonist receptors that initiate platelet activation, downstream signaling molecules (e.g. small G-proteins and kinases) and changes in ligand-occupied alpha(IIb)beta(3) that c...

journal_title：Current opinion in cell biology

authors： Parise LV

更新日期：1999-10-01 00:00:00

abstract：:Particle engulfment during phagocytosis has long been appreciated to be an active, actin-driven process. By contrast, the preceding stage--securing the target to the surface of the phagocyte--was thought to result from the passive diffusion of receptors along the membrane towards their ligands on the particle surface....

journal_title：Current opinion in cell biology

authors： Jaumouillé V,Grinstein S

更新日期：2011-02-01 00:00:00

abstract：:Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate ...

journal_title：Current opinion in cell biology

authors： Garrod D,Chidgey M,North A

更新日期：1996-10-01 00:00:00

abstract：:Oocyte cytoplasmic factors can reprogramme the sperm genome during fertilisation or the somatic cell genome during cloning. Diverse reprogramming machinery acts sequentially and interdependently on the imported genome to drive it to totipotency, but their three-dimensional interactions in the cytoplasm remain unknown....

journal_title：Current opinion in cell biology

authors： Kang YK,Lee KK,Han YM

更新日期：2003-06-01 00:00:00

abstract：:In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two...

journal_title：Current opinion in cell biology

authors： Ohi R,Gould KL

更新日期：1999-04-01 00:00:00

abstract：:Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the...

journal_title：Current opinion in cell biology

authors： Nicchitta CV

更新日期：2002-08-01 00:00:00

abstract：:As a key part of the mechanism which controls growth and division, cells are able to respond to a variety of intracellular and extracellular stimuli. Significant progress has been made in the understanding of the biochemical mechanisms underlying mating-factor signal transduction in Saccharomyces cerevisiae. Some of t...

journal_title：Current opinion in cell biology

authors： Oehlen B,Cross FR

更新日期：1994-12-01 00:00:00

abstract：:A key difference between yeast and metazoans is the need of the latter to regulate cell proliferation and growth to create organs (and organisms) of reproducible size and shape. Great progress has been made in understanding how growth, cell size and the cell cycle are controlled in metazoans. Recent work has shown tha...

journal_title：Current opinion in cell biology

authors： Leevers SJ,McNeill H

更新日期：2005-12-01 00:00:00

abstract：:To preserve fitness in unpredictable, fluctuating environments, a range of biological systems probabilistically generate variant phenotypes--a process often referred to as 'bet-hedging', after the financial practice of diversifying assets to minimize risk in volatile markets. The molecular mechanisms enabling bet-hedg...

journal_title：Current opinion in cell biology

authors： Weinberger LS

更新日期：2015-12-01 00:00:00

abstract：:Recent evidence corroborates the idea that the structure of the nucleolus need not be strictly maintained for proper function, suggesting that the organelle is composed of supramolecular assemblies formed during rRNA synthesis. More controversial is whether the nucleolus exists in the absence of rRNA synthesis and whe...

journal_title：Current opinion in cell biology

authors： Mélèse T,Xue Z

更新日期：1995-06-01 00:00:00

abstract：:Although it is universally accepted that protein synthesis occurs in the cytoplasm, the possibility that translation can also take place in the nucleus has been hotly debated. Reports have been published claiming to demonstrate nuclear translation, but alternative explanations for these results have not been excluded,...

journal_title：Current opinion in cell biology

authors： Dahlberg JE,Lund E

更新日期：2004-06-01 00:00:00

abstract：:Peroxisomes are part of the ubiquitous set of eukaryotic organelles. They are small, single membrane bounded vesicles, specialized in the degradation of very-long-chain fatty acids and in synthesis of myelin lipids. Once considered inconspicuous, recent new insights in the formation and function of peroxisomes have re...

journal_title：Current opinion in cell biology

authors： van der Zand A,Tabak HF

更新日期：2013-08-01 00:00:00

abstract：:Germline stem cells (GSCs) sustain gametogenesis during the life of organisms. Recent progress has substantially extended our understanding of GSC behavior, including the mechanisms of stem cell self-renewal, asymmetric stem cell division, stem cell niches, dedifferentiation, and tissue aging. GSCs typically are highl...

journal_title：Current opinion in cell biology

authors： Yuan H,Yamashita YM

更新日期：2010-12-01 00:00:00

abstract：:Protein splicing is a series of enzymatic events involving intramolecular protein breakage, rejoining and intron homing, in which introns are able to promote the recombinative transposition of their own coding sequences. Eukaryotic and prokaryotic spliced proteins have conserved similar gene structure, but little amin...

journal_title：Current opinion in cell biology

authors： Neff NF

更新日期：1993-12-01 00:00:00