Cytoskeletal control of growth and cell fate switching.

abstract：:Clathrin-mediated endocytosis (CME) is the main endocytic pathway supporting housekeeping functions in cells. However, CME may be too slow to internalize proteins from the cell surface during certain physiological processes such as reaction to stress hormones ('fight-or-flight' reaction), chemotaxis or compensatory en...

journal_title：Current opinion in cell biology

authors： Watanabe S,Boucrot E

更新日期：2017-08-01 00:00:00

abstract：:Blood vessel development is a vital process during embryonic development, during tissue growth, regeneration and disease processes in the adult. In the past decade researchers have begun to unravel basic molecular mechanisms that regulate the formation of vascular lumen, sprouting angiogenesis, fusion of vessels, and ...

journal_title：Current opinion in cell biology

authors： Wacker A,Gerhardt H

更新日期：2011-12-01 00:00:00

abstract：:The Golgi apparatus occupies a central position within the secretory pathway where it is a hub for vesicle trafficking. Distinct classes of transport vesicles traffic diverse cargoes into and out of this organelle, as well as between the different Golgi subcompartments. A key feature of Golgi trafficking is the specif...

journal_title：Current opinion in cell biology

authors： Witkos TM,Lowe M

更新日期：2017-08-01 00:00:00

abstract：:Tight junctions create a paracellular barrier between both epithelial and endothelial cells. Recent advances have helped define their molecular composition and regulation. Studies in cultured cell lines provide new insights into how assembly and barrier properties may be controlled by signal transduction cascades. ...

journal_title：Current opinion in cell biology

authors： Anderson JM,Balda MS,Fanning AS

更新日期：1993-10-01 00:00:00

abstract：:Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the...

journal_title：Current opinion in cell biology

authors： Nicchitta CV

更新日期：2002-08-01 00:00:00

abstract：:Mitochondria provide an essential role in the maintenance of cellular homeostasis with regard to energy generation, redox signaling, and programmed cell death. Consequently, fast adaptation to metabolic changes associated with developmental demands or stress induction requires a balanced coordination of mitochondrial ...

journal_title：Current opinion in cell biology

authors： Franz A,Kevei É,Hoppe T

更新日期：2015-12-01 00:00:00

abstract：:The past several years have seen major advances in our understanding of the mechanisms of microtubule destabilization by oncoprotein18/stathmin (Op18/stathmin) and related proteins. New structural information has clearly shown how members of the Op18/stathmin protein family bind tubulin dimers and suggests models for ...

journal_title：Current opinion in cell biology

authors： Cassimeris L

更新日期：2002-02-01 00:00:00

abstract：:Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate ...

journal_title：Current opinion in cell biology

authors： Garrod D,Chidgey M,North A

更新日期：1996-10-01 00:00:00

abstract：:The insulin receptor substrates function at the heart of the insulin signalling network. It has recently become apparent that the intracellular localisation of these molecules is regulated in a precise manner that is critical for both the generation and the termination of the insulin signal. Some insulin receptor subs...

journal_title：Current opinion in cell biology

authors： Whitehead JP,Clark SF,Urso B,James DE

更新日期：2000-04-01 00:00:00

abstract：:Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors i...

journal_title：Current opinion in cell biology

authors： Hakes AE,Brand AH

更新日期：2019-10-01 00:00:00

abstract：:Actin polymerization generates the force that deforms the cell membrane, pulls the cell forward and propels endosomes and bacteria within the cell. The mechanism of force generation has been probed using experimental biomimetic systems where force generation and movement occur by the same actin-polymerization processe...

journal_title：Current opinion in cell biology

authors： Plastino J,Sykes C

更新日期：2005-02-01 00:00:00

abstract：:The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors. In the past year, s...

journal_title：Current opinion in cell biology

authors： Hood JK,Silver PA

更新日期：1999-04-01 00:00:00

abstract：:The relationship between cell growth (cell mass increase over time) and cell division is poorly understood in animal stem cells. Recent studies in several Drosophila stem cell types have provided the tools to interrogate this relationship. In several cases (brat, mei-P26, pros, bam, lethal giant larvae, polo), mutatio...

journal_title：Current opinion in cell biology

authors： Kohlmaier A,Edgar BA

更新日期：2008-12-01 00:00:00

abstract：:Piwi-interacting RNAs (piRNAs) were reported in 2006 as a novel class of small non-coding RNAs associated with Piwi proteins of the Argonaute/Piwi family. Recent studies have revealed not only the biogenesis of piRNAs and their roles in transposon silencing, but also the function of the Piwi-piRNA pathway in epigeneti...

journal_title：Current opinion in cell biology

authors： Peng JC,Lin H

更新日期：2013-04-01 00:00:00

abstract：:The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are un...

journal_title：Current opinion in cell biology

authors： Tacke R,Manley JL

更新日期：1999-06-01 00:00:00

abstract：:The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...

journal_title：Current opinion in cell biology

authors： Impens F,Vandekerckhove J,Gevaert K

更新日期：2010-12-01 00:00:00

abstract：:The concept that ostensibly tissue-specific stem cells can give rise to cells of heterologous lineages has gained support from studies using purified hematopoietic stem cells and sensitive donor-cell tracking methods. The ability to exploit these findings in clinical settings will probably depend on new insights into ...

journal_title：Current opinion in cell biology

authors： Goodell MA

更新日期：2001-12-01 00:00:00

abstract：:The structure and integrity of the mitochondrial compartment are features essential for it to function efficiently. The maintenance of mitochondrial structure in cells ranging from yeast to humans has been shown to require both ongoing fission and fusion. Recent characterization of many of the molecular components tha...

journal_title：Current opinion in cell biology

authors： Scott SV,Cassidy-Stone A,Meeusen SL,Nunnari J

更新日期：2003-08-01 00:00:00

abstract：:Within the class of integral membrane proteins, the bacterial porins display a remarkable resistance to denaturants and proteases. This stability is probably crucial for the formation of highly ordered, three-dimensional crystals. Structural analysis of these crystals has been possible in atomic detail. This analysis ...

journal_title：Current opinion in cell biology

authors： Schulz GE

更新日期：1993-08-01 00:00:00

abstract：:Cohesin, one of structural maintenance of chromosomes (SMC) complexes, forms a ring-shaped protein complex, and mediates sister chromatid cohesion for accurate chromosome segregation and precise genome inheritance. The cohesin ring entraps one or two DNA molecules to achieve cohesion, which is further regulated by coh...

journal_title：Current opinion in cell biology

authors： Nishiyama T

更新日期：2019-06-01 00:00:00

abstract：:Several recent scientific and technical developments have made it possible to postulate the use of the 'magic bullet' concept; that is, the identification of specific antigens present on tumor cells that can be targeted either by therapeutic antibodies or by small molecules. The use of monoclonal antibodies in cancer,...

journal_title：Current opinion in cell biology

authors： Houshmand P,Zlotnik A

更新日期：2003-10-01 00:00:00

abstract：:The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the extracellular matrix to permit normal remodeling and contribute to pathological tissue destruction and tumor cell invasion. More recently, the identification of specific matrix and non-matrix substrates for MMPs and the elucidation of ...

journal_title：Current opinion in cell biology

authors： McCawley LJ,Matrisian LM

更新日期：2001-10-01 00:00:00

abstract：:In the past decade, studies into the way in which intracellular bacterial pathogens hijack and subvert their hosts have provided many important insights into regulation of the actin cytoskeleton and cell motility, in addition to increasing our understanding of the infection process. Viral pathogens, however, may ultim...

journal_title：Current opinion in cell biology

authors： Ploubidou A,Way M

更新日期：2001-02-01 00:00:00

abstract：:Focal adhesion kinase (pp125FAK), a protein tyrosine kinase, has recently been suggested to regulate aspects of signalling induced by integrins and by certain growth factor and hormone receptors. New studies indicate that the domains of pp125FAK regulate its interactions with integrin subunits, other protein tyrosine ...

journal_title：Current opinion in cell biology

authors： Schaller MD,Parsons JT

更新日期：1994-10-01 00:00:00

abstract：:Cell migration requires the integration and coordination of specific focal adhesion dynamics at the cell front, center and rear. In this review, we will present our understanding of the regulation of adhesion turnover and disassembly in various regions of the cell. Adhesion turnover involves a number of tyrosine kinas...

journal_title：Current opinion in cell biology

authors： Broussard JA,Webb DJ,Kaverina I

更新日期：2008-02-01 00:00:00

abstract：:Germline stem cells (GSCs) sustain gametogenesis during the life of organisms. Recent progress has substantially extended our understanding of GSC behavior, including the mechanisms of stem cell self-renewal, asymmetric stem cell division, stem cell niches, dedifferentiation, and tissue aging. GSCs typically are highl...

journal_title：Current opinion in cell biology

authors： Yuan H,Yamashita YM

更新日期：2010-12-01 00:00:00

abstract：:Force arising from actin polymerization and myosin activity drives a number of different actin-based cell movements. Several new reports support previous data suggesting that actin polymerization drives lamellipodial protrusion and bacterial propulsion, and one report describes a more indirect role for actin assembly ...

journal_title：Current opinion in cell biology

authors： Cramer LP,Mitchison TJ,Theriot JA

更新日期：1994-02-01 00:00:00

abstract：:The Arp2/3 complex is necessary for nucleating the formation of branched networks of actin filaments at the cell cortex, and an increasing number of proteins able to activate the Arp2/3 complex have been described. The Wiskott-Aldrich syndrome protein (WASP) family and cortactin comprise the large majority of the know...

journal_title：Current opinion in cell biology

authors： Weaver AM,Young ME,Lee WL,Cooper JA

更新日期：2003-02-01 00:00:00

abstract：:Most cancers arise in epithelia, the tissue type that lines all body cavities. The organization of epithelia enables them to act as a barrier and perform vectorial transport of molecules between body compartments. Crucial for their organization and function is a highly specialized network of cell adhesion and polarity...

journal_title：Current opinion in cell biology

authors： Hinck L,Näthke I

更新日期：2014-02-01 00:00:00

abstract：:The mitotic and meiotic cell cycle share many regulators, but there are also important differences between the two processes. The meiotic maturation of Xenopus oocytes has proved useful for understanding the regulation of Cdc2-cyclin-B, a key activator of G2/M progression. New insights have been made recently into the...

journal_title：Current opinion in cell biology

authors： Nebreda AR,Ferby I

更新日期：2000-12-01 00:00:00