Dimensions in cell migration.

abstract：:A major goal in cell biology is to understand the functional organization of macromolecular complexes in vivo. Electron microscopy is helping cell biologists to achieve this goal, thanks to its ability to resolve structural details in the nanometer range. While issues related to specimen preparation, imaging, and imag...

journal_title：Current opinion in cell biology

authors： Hoenger A,McIntosh JR

更新日期：2009-02-01 00:00:00

abstract：:Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate ...

journal_title：Current opinion in cell biology

authors： Garrod D,Chidgey M,North A

更新日期：1996-10-01 00:00:00

abstract：:Cell migration is a universal process involving different morphologies and mechanisms in different cell types and tissue environments. Prespecified cell-type-specific patterns of cell migration can be classified into single cell migration (amoeboid, mesenchymal) and collective migration modes (cell sheets, strands, tu...

journal_title：Current opinion in cell biology

authors： Friedl P

更新日期：2004-02-01 00:00:00

abstract：:In Caenorhabditis elegans, cell migration is guided by localized cues, including molecules such as EGL-17/FGF and UNC-6/netrin. These external cues are linked to an intracellular response to migrate, at least in part, by CED-5, a homolog of DOCK180/MBC, and MIG-2, a Rac-like GTPase. In addition, metalloproteases are r...

journal_title：Current opinion in cell biology

authors： Blelloch R,Newman C,Kimble J

更新日期：1999-10-01 00:00:00

abstract：:Transcriptional coactivators enhance gene expression by associating with sequence-specific transcription factors and serve as the primary targets of developmental and physiological signals in diverse biological processes. Recent studies have revealed key roles for transcriptional coactivators in the control of gene ex...

journal_title：Current opinion in cell biology

authors： Liu N,Olson EN

更新日期：2006-12-01 00:00:00

abstract：:The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are un...

journal_title：Current opinion in cell biology

authors： Tacke R,Manley JL

更新日期：1999-06-01 00:00:00

abstract：:Actin polymerization generates the force that deforms the cell membrane, pulls the cell forward and propels endosomes and bacteria within the cell. The mechanism of force generation has been probed using experimental biomimetic systems where force generation and movement occur by the same actin-polymerization processe...

journal_title：Current opinion in cell biology

authors： Plastino J,Sykes C

更新日期：2005-02-01 00:00:00

abstract：:The shaping of the vertebrate embryonic body plan depends heavily on the narrowing and lengthening (convergence and extension) of embryonic tissues by cell intercalation, a process by which cells actively crawl between one another along the axis of convergence to produce a narrower, longer array. We discuss recent evi...

journal_title：Current opinion in cell biology

authors： Skoglund P,Keller R

更新日期：2010-10-01 00:00:00

abstract：:The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...

journal_title：Current opinion in cell biology

authors： Impens F,Vandekerckhove J,Gevaert K

更新日期：2010-12-01 00:00:00

abstract：:The Sec61 and SecYEG translocation channels mediate the selective transport of proteins across the endoplasmic reticulum and bacterial inner membrane, respectively. These channels are also responsible for the integration of membrane proteins. To accomplish these two critical events in protein expression, the transport...

journal_title：Current opinion in cell biology

authors： Mandon EC,Trueman SF,Gilmore R

更新日期：2009-08-01 00:00:00

abstract：:Cell adhesion occurs via a highly regulated set of sequential interactions. Prototypic components of a variety of adhesion cascades are discussed, including integrins, triggering molecules and lectin-carbohydrate interactions. Selectivity and efficiency are achieved by utilizing the right combination of multiple adhes...

journal_title：Current opinion in cell biology

authors： Schweighoffer T,Shaw S

更新日期：1992-10-01 00:00:00

abstract：:In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single cell level have revealed that transcriptional kinetics are high...

journal_title：Current opinion in cell biology

authors： Suter DM,Molina N,Naef F,Schibler U

更新日期：2011-12-01 00:00:00

abstract：:There is a growing appreciation that metabolic signals are integrated and coupled to cell cycle progression. However, the molecular wiring that connects nutrient availability, biosynthetic intermediates and energetic balance to the core cell cycle machinery remains incompletely understood. In this review, we explore t...

journal_title：Current opinion in cell biology

authors： Lee IH,Finkel T

更新日期：2013-12-01 00:00:00

abstract：:Cellular microtubules are mosaic polymers assembled from multiple αβ-tubulin isoforms bearing chemically diverse posttranslational modifications. This tubulin diversity constitutes a combinatorial code that regulates microtubule interactions with cellular effectors and alters their intrinsic dynamic and mechanical pro...

journal_title：Current opinion in cell biology

authors： Roll-Mecak A

更新日期：2019-02-01 00:00:00

abstract：:Cilia (and flagella) are microtubule-based protrusions that are found in single or multiple copies on the surface of most eukaryotic cells. Defects in cilia formation and/or function have now been correlated with an expanding spectrum of human genetic diseases termed ciliopathies. Recent work indicates that cilia are ...

journal_title：Current opinion in cell biology

authors： Verhey KJ,Yang W

更新日期：2016-08-01 00:00:00

abstract：:The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings...

journal_title：Current opinion in cell biology

authors： Phua SC,Nihongaki Y,Inoue T

更新日期：2018-02-01 00:00:00

abstract：:Mitochondria are classically known as the essential energy producers in cells. As such, the activation of mitochondrial metabolism upon cellular differentiation was deemed a necessity to fuel the high metabolic needs of differentiated cells. However, recent studies have revealed a direct role for mitochondrial activit...

journal_title：Current opinion in cell biology

authors： Khacho M,Slack RS

更新日期：2017-12-01 00:00:00

abstract：:Golgins are a family of coiled-coil proteins associated with the Golgi apparatus necessary for tethering events in membrane fusion and as structural supports for Golgi cisternae. Recent work has shown that golgins such as GM130, golgin-45 and p115 bind to Rab GTPases via their coiled-coil domains, and that GM130, rath...

journal_title：Current opinion in cell biology

authors： Barr FA,Short B

更新日期：2003-08-01 00:00:00

abstract：:Cyclic AMP regulates a myriad of cellular processes through the cAMP-dependent protein kinase A. In many cases, activation of protein kinase A leads to altered patterns of gene transcription. Identification of the cAMP-response-element-binding-protein as a major nuclear substrate for protein kinase A accounts for many...

journal_title：Current opinion in cell biology

authors： Lee KA

更新日期：1991-12-01 00:00:00

abstract：:Recently there have been advances in studies of the molecular biology of the receptor for CNTF. In contrast with the receptors for other known neurotrophic factors, which belong to the family of receptor tyrosine kinases, the CNTF receptor belongs to the family of cytokine receptors. This review will describe the stru...

journal_title：Current opinion in cell biology

authors： Davis S,Yancopoulos GD

更新日期：1993-04-01 00:00:00

abstract：:Chemotaxis allows bacteria to follow gradients of nutrients and other environmental stimuli. The bacterium Escherichia coli performs chemotaxis via a run-and-tumble strategy in which sensitive temporal comparisons lead to a biased random walk, with longer runs in the preferred gradient direction. The chemotaxis networ...

journal_title：Current opinion in cell biology

authors： Sourjik V,Wingreen NS

更新日期：2012-04-01 00:00:00

abstract：:Recent advances in several key areas of fibronectin biology are discussed. These include its expression, from transcription to secretion of dimers, the structural requirements for several of the binding activities, potential roles for alternatively spliced segments in cell adhesion, and the assembly of a fibronectin m...

journal_title：Current opinion in cell biology

authors： Schwarzbauer JE

更新日期：1991-10-01 00:00:00

abstract：:Vesicle and tubule transport containers move proteins and lipids from one membrane system to another. Newly forming transport containers frequently have electron-dense coats. Coats coordinate the accumulation of cargo and sculpt the membrane. Recent advances have shown that components of both COP1 and clathrin-adaptor...

journal_title：Current opinion in cell biology

authors： McMahon HT,Mills IG

更新日期：2004-08-01 00:00:00

abstract：:Several new members of the gelsolin family have been discovered in the past year. Determination of the structure of gelsolin and identification of lysophosphatidic acid as a negative regulator provide novel functional insights. Gelsolin is an obligate downstream effector of Rac for motility in dermal fibroblasts, regu...

journal_title：Current opinion in cell biology

authors： Kwiatkowski DJ

更新日期：1999-02-01 00:00:00

abstract：:The histones which pack new DNA during the S phase of animal cells are made from mRNAs that are cleaved at their 3' end but not polyadenylated. Some of the factors used in this reaction are unique to it while others are shared with the polyadenylation process that generates all other mRNAs. Recent work has begun to sh...

journal_title：Current opinion in cell biology

authors： Romeo V,Schümperli D

更新日期：2016-06-01 00:00:00

abstract：:Secretion of proteins across the bacterial outer membrane takes place via a variety of mechanisms from simple one-component systems to complex multicomponent pathways. Secretion pathways can be organized into evolutionarily and functionally related groups, which highlight their relationship with organelle biogenesis. ...

journal_title：Current opinion in cell biology

authors： Thanassi DG,Hultgren SJ

更新日期：2000-08-01 00:00:00

abstract：:Protein degradation plays key roles in diverse pathways in cell division, growth and differentiation. Aberrant stabilization of crucial proteins participating in oncogenic pathways is often observed in cancer. The importance of proper protein turnover is exemplified by the SCF(Fbxw7) ubiquitin ligase, which is frequen...

journal_title：Current opinion in cell biology

authors： Kourtis N,Strikoudis A,Aifantis I

更新日期：2015-12-01 00:00:00

abstract：:Classical heterochromatin chromosomal landmarks, such as centromeres and telomeres, are characterized by specific chromatin signatures. Among these, the incorporation of histone variants has recently emerged as an important feature. Using the centromere as a paradigm, we consider the role of histone variant dynamics i...

journal_title：Current opinion in cell biology

authors： Boyarchuk E,Montes de Oca R,Almouzni G

更新日期：2011-06-01 00:00:00

abstract：:It is widely recognized that after endocytosis, internalized cargo is delivered to endosomes that act as sorting stations. The limiting membrane of endosomes contain specialized subregions, or microdomains, that represent distinct functions of the endosome, including regions competing for cargo capture leading to degr...

journal_title：Current opinion in cell biology

authors： Norris A,Grant BD

更新日期：2020-08-01 00:00:00

abstract：:During the preceding year significant progress has been made in our understanding of laminin structure and expression. Highlights include the identification of new subunit chains and molecular isoforms as well as new information on tissue-specific gene expression, laminin self-assembly and interactions with other matr...

journal_title：Current opinion in cell biology

authors： Tryggvason K

更新日期：1993-10-01 00:00:00