Abstract:
:Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate from the interplay among ligands and receptors is greatly preserved. In this review we will cover the latest findings on the different mechanisms for Notch activation and signaling. The regulation of this pathway is essential to understand development, cell differentiation and disease.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Bigas A,Espinosa Ldoi
10.1016/j.ceb.2018.06.010subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1-7eissn
0955-0674issn
1879-0410pii
S0955-0674(18)30026-7journal_volume
55pub_type
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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