Abstract:
:Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulated storage and release of lipids to fulfil their fundamental roles in energy metabolism, membrane synthesis and provision of lipid-derived signaling molecules. Although small LDs are observed in all types of eukaryotic cells, it is adipocytes that present the widest range of sizes up to the massive unilocular droplet of a white adipocyte. Our knowledge of the proteins and associated processes that control LD dynamics is improving. The dynamic expression of LD-associated proteins is vital for controlling LD biology and is most apparent during adipocyte differentiation. Recent findings on the molecular mechanisms of lipid droplet enlargement reveal the importance of distinct functional groups of proteins and phospholipids.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Barneda D,Christian Mdoi
10.1016/j.ceb.2017.02.002subject
Has Abstractpub_date
2017-08-01 00:00:00pages
9-15eissn
0955-0674issn
1879-0410pii
S0955-0674(16)30212-5journal_volume
47pub_type
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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