Abstract：
:The multimolecular WAVE regulatory (WRC) and Arp2/3 complexes are primarily responsible to generate pushing forces at migratory leading edges by promoting branch elongation of actin filaments. The architectural complexity of these units betrays the necessity to impose a tight control on their activity. This is exerted through temporally coordinated and coincident signals which limit the intensity and duration of this activity. In addition, interactions of the WRC and Arp2/3 complexes with membrane binding and surprisingly membrane trafficking proteins is also emerging, revealing the existence of an 'endocytic wiring system' that spatially restrict branched actin elongation for the execution of polarized functions during cell migration.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Bisi S,Disanza A,Malinverno C,Frittoli E,Palamidessi A,Scita Gdoi
10.1016/j.ceb.2013.04.001subject
Has Abstractpub_date
2013-10-01 00:00:00pages
565-73issue
5eissn
0955-0674issn
1879-0410pii
S0955-0674(13)00064-1journal_volume
25pub_type
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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