Abstract:
:Cellular microtubules are mosaic polymers assembled from multiple αβ-tubulin isoforms bearing chemically diverse posttranslational modifications. This tubulin diversity constitutes a combinatorial code that regulates microtubule interactions with cellular effectors and alters their intrinsic dynamic and mechanical properties. Cells generate stereotyped and complex tubulin modification patterns that are important for their specialized functions. Here we give a brief overview of the tubulin genetic and chemical diversity and highlight recent advances in our understanding of how the tubulin code regulates essential biological processes ranging from intracellular cargo transport, to cell division and cardiomyocyte contraction. Finally, we speculate on the molecular mechanisms for the generation and maintenance of the complex stereotyped modification patterns that form cellular microtubule mosaics.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Roll-Mecak Adoi
10.1016/j.ceb.2018.10.009subject
Has Abstractpub_date
2019-02-01 00:00:00pages
102-108eissn
0955-0674issn
1879-0410pii
S0955-0674(18)30138-8journal_volume
56pub_type
杂志文章,评审abstract::Several proteins involved in exocytosis have been identified recently, but it is still completely unclear which molecules perform the fusion event itself. Although in viral fusion the fusion proteins are known, even there the molecular mechanism remains controversial. Investigation of single fusion events by electroph...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(95)80007-7
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abstract::Research over the past two decades has defined a window of time in the early/mid G1 phase of the cell cycle during which mammalian cells are responsive to extracellular signals. Recent evidence indicates that this period ends with the phosphorylation of the retinoblastoma protein, enabling the cells to pass through th...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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abstract::The cortical force-generating machinery pulls on dynamic plus-ends of astral microtubules to control spindle position and orientation, which underlie division type specification and cellular patterning in many eukaryotic cells. A prior work identified cytoplasmic dynein, a minus-end directed microtubule motor, as a ke...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2019.03.001
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(91)90051-y
更新日期:1991-10-01 00:00:00
abstract::Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and membranes. Innate immune cells and transformed cancer cells share the capacity for both constitutive and induced macropinocytosis, which...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:1996-06-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:1999-12-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:1993-04-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2013.07.010
更新日期:2013-12-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(00)00234-9
更新日期:2001-08-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2013.05.008
更新日期:2013-10-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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doi:10.1016/s0955-0674(96)80103-7
更新日期:1996-10-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2005.02.011
更新日期:2005-04-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/0955-0674(93)90128-d
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(97)80030-0
更新日期:1997-08-01 00:00:00
abstract::The mitotic and meiotic cell cycle share many regulators, but there are also important differences between the two processes. The meiotic maturation of Xenopus oocytes has proved useful for understanding the regulation of Cdc2-cyclin-B, a key activator of G2/M progression. New insights have been made recently into the...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(00)00150-2
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2008.12.004
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2009.03.006
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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abstract::A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Cell Biology. ...
journal_title:Current opinion in cell biology
pub_type:
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更新日期:2001-08-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2018.01.008
更新日期:2018-02-01 00:00:00
abstract::Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals. During the past year, numerous candidate downstream targets for these GTPases have been identified using affinity chromatography and yeast two-hybrid t...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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abstract::The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including ...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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