Transforming growth factor-beta-related genes in Drosophila and vertebrate development.

abstract：:The Golgi apparatus occupies a central position within the secretory pathway where it is a hub for vesicle trafficking. Distinct classes of transport vesicles traffic diverse cargoes into and out of this organelle, as well as between the different Golgi subcompartments. A key feature of Golgi trafficking is the specif...

journal_title：Current opinion in cell biology

authors： Witkos TM,Lowe M

更新日期：2017-08-01 00:00:00

abstract：:Intracellular signals are received and generated by the alpha(IIb)beta(3) integrin on platelets. Recent advances have been made in the areas of agonist receptors that initiate platelet activation, downstream signaling molecules (e.g. small G-proteins and kinases) and changes in ligand-occupied alpha(IIb)beta(3) that c...

journal_title：Current opinion in cell biology

authors： Parise LV

更新日期：1999-10-01 00:00:00

abstract：:Primordial germ cells (PGCs), the progenitors of the gametes, migrate from the position where they are specified towards the region where the gonad develops. To reach their target, the PGCs obtain directional cues from cells positioned along their migration path. One such cue, the chemokine SDF-1, has recently been fo...

journal_title：Current opinion in cell biology

authors： Raz E

更新日期：2004-04-01 00:00:00

abstract：:Spatiotemporal Ca2+ signalling in the cytoplasm is currently understood as an excitation phenomenon by analogy with electrical excitation in the plasma membrane. In many cell types, Ca2+ waves and Ca2+ oscillations are mediated by inositol 1,4,5-trisphosphate (IP3) receptor/Ca2+ channels in the endoplasmic reticulum m...

journal_title：Current opinion in cell biology

authors： Miyazaki S

更新日期：1995-04-01 00:00:00

abstract：:Cell migration is a universal process involving different morphologies and mechanisms in different cell types and tissue environments. Prespecified cell-type-specific patterns of cell migration can be classified into single cell migration (amoeboid, mesenchymal) and collective migration modes (cell sheets, strands, tu...

journal_title：Current opinion in cell biology

authors： Friedl P

更新日期：2004-02-01 00:00:00

abstract：:Several new members of the gelsolin family have been discovered in the past year. Determination of the structure of gelsolin and identification of lysophosphatidic acid as a negative regulator provide novel functional insights. Gelsolin is an obligate downstream effector of Rac for motility in dermal fibroblasts, regu...

journal_title：Current opinion in cell biology

authors： Kwiatkowski DJ

更新日期：1999-02-01 00:00:00

abstract：:The shaping of the vertebrate embryonic body plan depends heavily on the narrowing and lengthening (convergence and extension) of embryonic tissues by cell intercalation, a process by which cells actively crawl between one another along the axis of convergence to produce a narrower, longer array. We discuss recent evi...

journal_title：Current opinion in cell biology

authors： Skoglund P,Keller R

更新日期：2010-10-01 00:00:00

abstract：:The actin supergene family encodes a number of structurally related, but perhaps functionally distinct, protein isoforms that regulate contractile potential in muscle tissues and help to control the shape as well as the motility of non-muscle cells. In spite of the documented conservation amongst isoactin genes and th...

journal_title：Current opinion in cell biology

authors： Herman IM

更新日期：1993-02-01 00:00:00

abstract：:The multimolecular WAVE regulatory (WRC) and Arp2/3 complexes are primarily responsible to generate pushing forces at migratory leading edges by promoting branch elongation of actin filaments. The architectural complexity of these units betrays the necessity to impose a tight control on their activity. This is exerted...

journal_title：Current opinion in cell biology

authors： Bisi S,Disanza A,Malinverno C,Frittoli E,Palamidessi A,Scita G

更新日期：2013-10-01 00:00:00

abstract：:One parental copy of an imprinted gene is invariably expressed during development. The characteristic of the heritable epigenetic germline imprint remains elusive, but recent evidence stresses the necessity for additional post-zygotic epigenetic modifications to account for this temporal and tissue-specific mono-allel...

journal_title：Current opinion in cell biology

authors： Surani MA

更新日期：1994-06-01 00:00:00

abstract：:Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial cont...

journal_title：Current opinion in cell biology

authors： Harper CS,White AJ,Lackner LL

更新日期：2020-08-01 00:00:00

abstract：:Studies of yeast transcription factors have contributed greatly to understanding basic molecular mechanisms of eukaryotic gene regulation, largely due to powerful genetic approaches that are unavailable in other organisms. The broad outlines of these mechanisms are fairly well understood, and there is an increasing nu...

journal_title：Current opinion in cell biology

authors： Struhl K

更新日期：1993-06-01 00:00:00

abstract：:Nuclear mRNA export through the nuclear pore complex has been proposed to be a unidirectional, signal-mediated and energy-dependent process. Evidence exists that this process can be influenced by many factors including other steps in the pathway of cytoplasmic mRNA formation, sequences of the RNA substrate that are ei...

journal_title：Current opinion in cell biology

authors： Maquat LE

更新日期：1991-12-01 00:00:00

abstract：:A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of...

journal_title：Current opinion in cell biology

authors： Gruenberg J,Clague MJ

更新日期：1992-08-01 00:00:00

abstract：:Living cells must be able to switch between growth and differentiation with high fidelity and precise spatial control to ensure that normal tissue patterns are formed in the embryo and maintained throughout adult life. Most work on cell proliferation focuses on elucidating the signaling pathways responsible for contro...

journal_title：Current opinion in cell biology

authors： Mammoto A,Ingber DE

更新日期：2009-12-01 00:00:00

abstract：:As a 'double-edged sword', neutrophil (polymorphonuclear leukocyte) migration across epithelial-lined organs is an important component of host defense, but it also results in epithelial pathophysiology and disease symptoms. There have been significant advances in better understanding the mechanisms of how leukocytes c...

journal_title：Current opinion in cell biology

authors： Zen K,Parkos CA

更新日期：2003-10-01 00:00:00

abstract：:A major current issue in vesicle trafficking is whether NSF (N-ethylmaleimide-sensitive factor) and alpha-SNAP (alpha-soluble NSF attachment protein) are required prior to SNARE (SNAP receptor) complex formation to allow vesicle docking, or after docking at a step close to membrane fusion. Recent studies of yeast vacu...

journal_title：Current opinion in cell biology

authors： Hay JC,Scheller RH

更新日期：1997-08-01 00:00:00

abstract：:Evolution of the mammalian sex chromosomes heavily impacts on the expression of X-encoded genes, both in marsupials and placental mammals. The loss of genes from the Y chromosome forced a two-fold upregulation of dose sensitive X-linked homologues. As a corollary, female cells would experience a lethal dose of X-linke...

journal_title：Current opinion in cell biology

authors： Gribnau J,Grootegoed JA

更新日期：2012-06-01 00:00:00

abstract：:Cellular microtubules are mosaic polymers assembled from multiple αβ-tubulin isoforms bearing chemically diverse posttranslational modifications. This tubulin diversity constitutes a combinatorial code that regulates microtubule interactions with cellular effectors and alters their intrinsic dynamic and mechanical pro...

journal_title：Current opinion in cell biology

authors： Roll-Mecak A

更新日期：2019-02-01 00:00:00

abstract：:Emerging studies indicate that connexins have activities completely unrelated to gap junctions and, conversely, that non-connexin proteins can form gap junction channels. ...

journal_title：Current opinion in cell biology

authors： Stout C,Goodenough DA,Paul DL

更新日期：2004-10-01 00:00:00

abstract：:The conserved Aurora family of protein kinases have emerged as crucial regulators of mitosis and cytokinesis. Despite their high degree of homology, Aurora A and B have very distinctive localisations and functions: Aurora A associates with the spindle poles to regulate entry into mitosis, centrosome maturation and spi...

journal_title：Current opinion in cell biology

authors： Carmena M,Ruchaud S,Earnshaw WC

更新日期：2009-12-01 00:00:00

abstract：:Modulation of energy metabolism is emerging as a key aspect associated with cell fate transition. The establishment of a correct metabolic program is particularly relevant for neural cells given their high bioenergetic requirements. Accordingly, diseases of the nervous system commonly involve mitochondrial impairment....

journal_title：Current opinion in cell biology

authors： Lorenz C,Prigione A

更新日期：2017-12-01 00:00:00

abstract：:The principal subunits of a large superfamily of plasma-membrane cation channels are functionally autonomous in ion conductance and in gating by membrane potential and intracellular ligands. Recent work has located the structural elements responsible for the ion conductance and gating of these channels. These studies ...

journal_title：Current opinion in cell biology

authors： Catterall WA

更新日期：1994-08-01 00:00:00

abstract：:The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including ...

journal_title：Current opinion in cell biology

authors： Ferretti E,Hadjantonakis AK

更新日期：2019-12-01 00:00:00

abstract：:Tight junctions create a paracellular barrier between both epithelial and endothelial cells. Recent advances have helped define their molecular composition and regulation. Studies in cultured cell lines provide new insights into how assembly and barrier properties may be controlled by signal transduction cascades. ...

journal_title：Current opinion in cell biology

authors： Anderson JM,Balda MS,Fanning AS

更新日期：1993-10-01 00:00:00

abstract：:Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown that PcG mechanisms control a large number of genes regulating many cellular functions and all developmental pathways. Cur...

journal_title：Current opinion in cell biology

authors： Schwartz YB,Pirrotta V

更新日期：2008-06-01 00:00:00

abstract：:The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depe...

journal_title：Current opinion in cell biology

authors： Doyle AD,Petrie RJ,Kutys ML,Yamada KM

更新日期：2013-10-01 00:00:00

abstract：:Apoptosis, or programmed cell death, plays an essential role in specific cell deletion during normal embryonic and adult development in vertebrate and invertebrate species. Recent evidence suggests that signal transduction pathways governing cellular proliferation and cell cycle progression also mediate the physiologi...

journal_title：Current opinion in cell biology

authors： Lee S,Christakos S,Small MB

更新日期：1993-04-01 00:00:00

abstract：:Antigen processing leads to binding of antigenic peptides to major histocompatibility complex (MHC) molecules, and these peptide-MHC complexes are recognized by T cells. The class I and class II MHC antigen processing pathways employ different mechanisms and patterns of intracellular transport that allow the two class...

journal_title：Current opinion in cell biology

authors： Harding CV,Geuze HJ

更新日期：1993-08-01 00:00:00

abstract：:This review discusses recent advances in our understanding of adhesion receptor trafficking in vitro, and extrapolates them as far as what is currently possible towards an understanding of migration in three dimensions in vivo. Our specific focus is the mechanisms for endocytosis and recycling of the two major classes...

journal_title：Current opinion in cell biology

authors： Jacquemet G,Humphries MJ,Caswell PT

更新日期：2013-10-01 00:00:00