Abstract:
:The conserved Aurora family of protein kinases have emerged as crucial regulators of mitosis and cytokinesis. Despite their high degree of homology, Aurora A and B have very distinctive localisations and functions: Aurora A associates with the spindle poles to regulate entry into mitosis, centrosome maturation and spindle assembly; Aurora B is a member of the Chromosomal Passenger Complex (CPC) that transfers from the inner centromere in early mitosis to the spindle midzone, equatorial cortex and midbody in late mitosis and cytokinesis. Aurora B functions include regulation of chromosome-microtubule interactions, cohesion, spindle stability and cytokinesis. This review will focus on how interacting proteins make this functional diversity possible by targeting the kinases to different subcellular locations and regulating their activity.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Carmena M,Ruchaud S,Earnshaw WCdoi
10.1016/j.ceb.2009.09.008subject
Has Abstractpub_date
2009-12-01 00:00:00pages
796-805issue
6eissn
0955-0674issn
1879-0410pii
S0955-0674(09)00172-0journal_volume
21pub_type
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