Abstract:
:AB toxins deliver their enzymatically active A domain to the cytosol. Some AB-toxins are able to penetrate cellular membranes from endosomes where the low pH triggers their translocation. One such toxin is diphtheria toxin and important features of its translocation mechanism have been unraveled during the last year. Other toxins depend on retrograde transport through the secretory pathway to the ER before translocation, and recent findings suggest that these toxins take advantage of the ER translocation machinery normally used for transport of cellular proteins. In addition, the intracellular targets of many of these toxins have been identified recently.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Falnes PO,Sandvig Kdoi
10.1016/s0955-0674(00)00109-5subject
Has Abstractpub_date
2000-08-01 00:00:00pages
407-13issue
4eissn
0955-0674issn
1879-0410pii
S0955-0674(00)00109-5journal_volume
12pub_type
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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