Abstract:
:Actin filament assembly is a tightly regulated process that functions in many aspects of cell physiology. Members of the Ena/VASP (Drosophila Enabled/vasodilator-stimulated phosphoprotein) family are key players in regulating actin filament assembly, in many cases through their association with binding partners that display a particular proline-rich motif, FPPPP. Ena/VASP proteins interact with these partners via the highly conserved Ena/VASP homology 1 (EVH1) domain. The diverse array of binding partners for EVH1 domains, including cytoskeletal proteins such as zyxin, transmembrane guidance receptors such as Roundabout, and the T-cell signaling protein Fyb/SLAP, shows that these interactions are likely to be important in a number of cellular processes that require regulated actin filament assembly.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Renfranz PJ,Beckerle MCdoi
10.1016/s0955-0674(01)00299-xsubject
Has Abstractpub_date
2002-02-01 00:00:00pages
88-103issue
1eissn
0955-0674issn
1879-0410pii
S095506740100299Xjournal_volume
14pub_type
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journal_title:Current opinion in cell biology
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