Fibronectin: from gene to protein.

abstract：:A nuclear pore complex (NPC) is a large protein assembly that mediates the nucleocytoplasmic exchange of molecules. During the cell cycle, NPCs assemble, disassemble, and dynamically change their distribution on assembled nuclear envelope (NE), whereas in post-mitosis, NPCs are extremely stable. Extensive studies on i...

journal_title：Current opinion in cell biology

authors： Imamoto N,Funakoshi T

更新日期：2012-08-01 00:00:00

abstract：:Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functi...

journal_title：Current opinion in cell biology

authors： Will CL,Lührmann R

更新日期：1997-06-01 00:00:00

abstract：:Research into the molecular mechanisms of target cell recognition by natural killer (NK) cells has recently progressed rapidly. NK cells express several MHC I recognizing receptors that inactivate the NK cells' functions. In pathological alterations of MHC I expression, the NK cell inhibitory receptors do not engage a...

journal_title：Current opinion in cell biology

authors： Timonen T,Helander TS

更新日期：1997-10-01 00:00:00

abstract：:Diverse post-translational modifications of histone amino termini represent an important epigenetic mechanism for the organisation of chromatin structure and the regulation of gene activity. Within the past two years, great progress has been made in understanding the functional implications of histone methylation; in ...

journal_title：Current opinion in cell biology

authors： Lachner M,Jenuwein T

更新日期：2002-06-01 00:00:00

abstract：:The COPII coat produces ER-derived transport vesicles. Recent findings suggest that the COPII coat is a highly dynamic polymer and that efficient capture of cargo molecules into COPII vesicles depends on several parameters, including export signals, membrane environment, metabolic control and the presence of a reperto...

journal_title：Current opinion in cell biology

authors： Antonny B,Schekman R

更新日期：2001-08-01 00:00:00

abstract：:Intracellular signals are received and generated by the alpha(IIb)beta(3) integrin on platelets. Recent advances have been made in the areas of agonist receptors that initiate platelet activation, downstream signaling molecules (e.g. small G-proteins and kinases) and changes in ligand-occupied alpha(IIb)beta(3) that c...

journal_title：Current opinion in cell biology

authors： Parise LV

更新日期：1999-10-01 00:00:00

abstract：:The G protein-coupled receptor (GPCR) family is among the most druggable families in the human proteome. GPCRs are involved in most physiological processes, and our ability to modulate their activity is a hallmark of modern pharmacology. The means by which the activity of GPCRs can be modulated have been expanded by e...

journal_title：Current opinion in cell biology

authors： Giguere PM,Kroeze WK,Roth BL

更新日期：2014-04-01 00:00:00

abstract：:Classical heterochromatin chromosomal landmarks, such as centromeres and telomeres, are characterized by specific chromatin signatures. Among these, the incorporation of histone variants has recently emerged as an important feature. Using the centromere as a paradigm, we consider the role of histone variant dynamics i...

journal_title：Current opinion in cell biology

authors： Boyarchuk E,Montes de Oca R,Almouzni G

更新日期：2011-06-01 00:00:00

abstract：:Considerable advances into the basis of RNA-polymerase-II-mediated transcriptional regulation have recently emerged. Biochemical, genetic and structural studies have contributed to novel insights into transcription, as well as the functional significance of covalent histone modifications. New details regarding transcr...

journal_title：Current opinion in cell biology

authors： Sims RJ 3rd,Mandal SS,Reinberg D

更新日期：2004-06-01 00:00:00

abstract：:Commitment to division requires that cells sense, interpret, and respond appropriately to multiple signals. In most eukaryotes, cells commit to division in G1 before DNA replication. Beyond a point, known as Start in yeast and the restriction point in mammals, cells will proceed through the cell cycle despite changes ...

journal_title：Current opinion in cell biology

authors： Johnson A,Skotheim JM

更新日期：2013-12-01 00:00:00

abstract：:As a 'double-edged sword', neutrophil (polymorphonuclear leukocyte) migration across epithelial-lined organs is an important component of host defense, but it also results in epithelial pathophysiology and disease symptoms. There have been significant advances in better understanding the mechanisms of how leukocytes c...

journal_title：Current opinion in cell biology

authors： Zen K,Parkos CA

更新日期：2003-10-01 00:00:00

abstract：:A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connecti...

journal_title：Current opinion in cell biology

authors： Shaw TJ,Martin P

更新日期：2016-10-01 00:00:00

abstract：:Actin filament assembly is a tightly regulated process that functions in many aspects of cell physiology. Members of the Ena/VASP (Drosophila Enabled/vasodilator-stimulated phosphoprotein) family are key players in regulating actin filament assembly, in many cases through their association with binding partners that d...

journal_title：Current opinion in cell biology

authors： Renfranz PJ,Beckerle MC

更新日期：2002-02-01 00:00:00

abstract：:Cell migration is a universal process involving different morphologies and mechanisms in different cell types and tissue environments. Prespecified cell-type-specific patterns of cell migration can be classified into single cell migration (amoeboid, mesenchymal) and collective migration modes (cell sheets, strands, tu...

journal_title：Current opinion in cell biology

authors： Friedl P

更新日期：2004-02-01 00:00:00

abstract：:There is accumulating evidence that lateral assemblies (rafts) of sphingolipids and cholesterol form platforms that serve to support numerous cellular events in membrane traffic and signal transduction. Raft membrane microdomains are thought to function by preferentially associating with specific proteins while exclud...

journal_title：Current opinion in cell biology

authors： Harder T,Simons K

更新日期：1997-08-01 00:00:00

abstract：:Mammalian Unc-51-like kinases 1 and 2 (ULK1 and ULK2) belong to the ULK/Atg1 family of serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 is best known for regulating flux through the autophagy pathway, it has evolutionarily conserved noncanonical functions in protein trafficking th...

journal_title：Current opinion in cell biology

authors： Wang B,Kundu M

更新日期：2017-04-01 00:00:00

abstract：:In the adult, angiogenesis, the formation of new blood vessels from pre-existing vasculature contributes to the pathogenesis of many disorders including cancer. The role of adhesion molecules, especially integrins, in pathological angiogenesis has long been the subject of investigation, mostly because of their potenti...

journal_title：Current opinion in cell biology

authors： Hodivala-Dilke K

更新日期：2008-10-01 00:00:00

abstract：:A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hier...

journal_title：Current opinion in cell biology

authors： Roskelley CD,Srebrow A,Bissell MJ

更新日期：1995-10-01 00:00:00

abstract：:Recently there have been advances in studies of the molecular biology of the receptor for CNTF. In contrast with the receptors for other known neurotrophic factors, which belong to the family of receptor tyrosine kinases, the CNTF receptor belongs to the family of cytokine receptors. This review will describe the stru...

journal_title：Current opinion in cell biology

authors： Davis S,Yancopoulos GD

更新日期：1993-04-01 00:00:00

abstract：:Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic...

journal_title：Current opinion in cell biology

authors： Burke B

更新日期：2018-06-01 00:00:00

abstract：:Cohesin, one of structural maintenance of chromosomes (SMC) complexes, forms a ring-shaped protein complex, and mediates sister chromatid cohesion for accurate chromosome segregation and precise genome inheritance. The cohesin ring entraps one or two DNA molecules to achieve cohesion, which is further regulated by coh...

journal_title：Current opinion in cell biology

authors： Nishiyama T

更新日期：2019-06-01 00:00:00

abstract：:The materials cells are made of are strikingly different from man-made materials. Metabolism keeps cells out of equilibrium. Motor proteins and energy-consuming polymerization drive shape changes and motion. In contrast to macroscopic machines, though, there is no clear distinction between the force generators and the...

journal_title：Current opinion in cell biology

authors： Mackintosh FC,Schmidt CF

更新日期：2010-02-01 00:00:00

abstract：:A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Cell Biology. ...

journal_title：Current opinion in cell biology

authors： Pines J,Lafont F

更新日期：2001-08-01 00:00:00

abstract：:In the past decade, studies into the way in which intracellular bacterial pathogens hijack and subvert their hosts have provided many important insights into regulation of the actin cytoskeleton and cell motility, in addition to increasing our understanding of the infection process. Viral pathogens, however, may ultim...

journal_title：Current opinion in cell biology

authors： Ploubidou A,Way M

更新日期：2001-02-01 00:00:00

abstract：:Inability to meet protein folding demands within the endoplasmic reticulum (ER) activates the unfolded protein response (UPR), a signaling pathway with both adaptive and apoptotic outputs. While some secretory cell types have a remarkable ability to increase protein folding capacity, their upper limits can be reached ...

journal_title：Current opinion in cell biology

authors： Shore GC,Papa FR,Oakes SA

更新日期：2011-04-01 00:00:00

abstract：:The number and variety of factors underlying control of gene expression have been frequently underestimated. Non-coding RNAs generated through pervasive transcription have recently been implicated in shaping the transcriptional landscape in different organisms from bacteria to higher eukaryotes, adding a previously un...

journal_title：Current opinion in cell biology

authors： Castelnuovo M,Stutz F

更新日期：2015-06-01 00:00:00

abstract：:Genetic analysis in model organisms has recently achieved a detailed molecular description of many key cellular processes controlling embryonic morphogenesis. To understand higher order tissue morphogenesis, we now need to define how these processes become integrated across different cell groups and cell layers. Here,...

journal_title：Current opinion in cell biology

authors： Zhang H,Gally C,Labouesse M

更新日期：2010-10-01 00:00:00

abstract：:The cerebral cortex is composed of hundreds of different types of neurons, which underlie its ability to perform highly complex neural processes. How cortical neurons are generated during development constitutes a major challenge in developmental neurosciences with important implications for brain repair and diseases....

journal_title：Current opinion in cell biology

authors： Tiberi L,Vanderhaeghen P,van den Ameele J

更新日期：2012-04-01 00:00:00

abstract：:Signaling involves the coordinated action of multiple molecules including stimuli, receptors and enzymes part of which interact with the transcriptional machinery and target chromatin. Signaling systems regulate the cell events responsible for survival, development and homeostasis. Many of the signaling pathways induc...

journal_title：Current opinion in cell biology

authors： Suganuma T,Workman JL

更新日期：2013-06-01 00:00:00

abstract：:Several homeotic genes controlling flower development have been characterized in Antirrhinum and Arabidopsis. Comparisons of their mutant phenotypes, expression patterns and genetic interactions have revealed that many of the basic mechanisms controlling flower development have been conserved in evolution, although im...

journal_title：Current opinion in cell biology

authors： Coen ES

更新日期：1992-12-01 00:00:00