Abstract:
:The materials cells are made of are strikingly different from man-made materials. Metabolism keeps cells out of equilibrium. Motor proteins and energy-consuming polymerization drive shape changes and motion. In contrast to macroscopic machines, though, there is no clear distinction between the force generators and the structural elements. Rather, the force-generating motor proteins are mixed with the elementary building blocks of cell structure on a molecular scale. The composite ensemble presents a new type of active material which is at the focus of intense current research. Simple model systems have been used successfully in exploring fundamental phenomena. Theoretical models are extending conventional soft matter approaches, and pioneering studies strive to analyze the complex nonequilibrium dynamics of living cells.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Mackintosh FC,Schmidt CFdoi
10.1016/j.ceb.2010.01.002subject
Has Abstractpub_date
2010-02-01 00:00:00pages
29-35issue
1eissn
0955-0674issn
1879-0410pii
S0955-0674(10)00004-9journal_volume
22pub_type
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2004.05.001
更新日期:2004-08-01 00:00:00
abstract::A key difference between yeast and metazoans is the need of the latter to regulate cell proliferation and growth to create organs (and organisms) of reproducible size and shape. Great progress has been made in understanding how growth, cell size and the cell cycle are controlled in metazoans. Recent work has shown tha...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2005.09.008
更新日期:2005-12-01 00:00:00
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journal_title:Current opinion in cell biology
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doi:10.1016/j.ceb.2005.02.011
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abstract::Cellular asymmetries have been proposed to play a role in plant embryogenesis. Genetic studies of Arabidopsis and other experimental approaches in several plant species have addressed the origins of cellular asymmetry in specific cases. Although zygote polarity, which precedes the formation of the apical-basal axis of...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(97)80087-7
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abstract::A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:1992-08-01 00:00:00
abstract::Cyclin-dependent kinase (CDK) 7 was originally implicated in cell cycle control by virtue of its ability to phosphorylate and activate other CDKs. Subsequently, both CDK7 and its partner, cyclin H, were found to be associated with the general transcription factor TFIIH, suggesting additional roles for CDK7 in transcri...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(96)80003-2
更新日期:1996-06-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/s0955-0674(96)80108-6
更新日期:1996-10-01 00:00:00
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
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journal_title:Current opinion in cell biology
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abstract::Genetic analysis in model organisms has recently achieved a detailed molecular description of many key cellular processes controlling embryonic morphogenesis. To understand higher order tissue morphogenesis, we now need to define how these processes become integrated across different cell groups and cell layers. Here,...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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更新日期:2000-02-01 00:00:00
abstract::The Sec61 and SecYEG translocation channels mediate the selective transport of proteins across the endoplasmic reticulum and bacterial inner membrane, respectively. These channels are also responsible for the integration of membrane proteins. To accomplish these two critical events in protein expression, the transport...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2009.04.010
更新日期:2009-08-01 00:00:00
abstract::Regulation of skeletal muscle determination and differentiation in vertebrates centers on a core regulatory network which is composed of two families of transcription factors, the MyoD group basic helix-loop-helix (bHLH) muscle regulatory factors (MRFs) and the myocyte enhancer factor 2 (MEF2) group of MADS-box regula...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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abstract::As a 'double-edged sword', neutrophil (polymorphonuclear leukocyte) migration across epithelial-lined organs is an important component of host defense, but it also results in epithelial pathophysiology and disease symptoms. There have been significant advances in better understanding the mechanisms of how leukocytes c...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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abstract::The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depe...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
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abstract::Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid and glucose homeostasis, inflammation and wound healing. In addition to ligand binding, phosphorylation can also regulate PPARs; the biological effects of phosphorylation depend on the stimulus, the kinase, the PPAR isotype, th...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2005.02.002
更新日期:2005-04-01 00:00:00
abstract::Neural induction is the process by which embryonic cells in the ectoderm make a decision to acquire a neural fate (to form the neural plate) rather than give rise to other structures such as epidermis or mesoderm. An influential model proposed a decade ago, the 'default model', postulated that ectodermal cells will be...
journal_title:Current opinion in cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ceb.2006.09.002
更新日期:2006-12-01 00:00:00