Protein O-mannosylation in the early secretory pathway.

Abstract:

:Protein O-mannosylation and N-glycosylation are essential post-translational modifications, which initiate in the endoplasmic reticulum (ER). In yeast, the two glycosylation machineries act at the Sec61 translocon complex where they can even compete for certain substrate proteins. N-linked glycans play a crucial role in the ER quality control of glycoproteins. In recent years, it became clear that in addition to its important functions for cell surface proteins, O-mannosylation impacts the ER protein homeostasis. These glycans can exclude unfavorable folding intermediates from futile folding attempts, increase the solubility of irreversibly misfolded proteins, and even mark them for degradation. O-Mannose glycoproteomics now captures the molecular complexity of this modification opening exciting opportunities to explore further roles of O-mannosylation in the early secretory pathway.

journal_name

Curr Opin Cell Biol

authors

Neubert P,Strahl S

doi

10.1016/j.ceb.2016.04.010

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

100-8

eissn

0955-0674

issn

1879-0410

pii

S0955-0674(16)30085-0

journal_volume

41

pub_type

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