Abstract:
:Polarity is defined by the segregation of cellular components along a defined axis. To polarize robustly, cells must be able to break symmetry and subsequently amplify these nascent asymmetries. Finally, asymmetric localization of signaling molecules must be translated into functional regulation of downstream effector pathways. Central to these behaviors are a diverse set of cell polarity networks. Within these networks, molecules exhibit varied behaviors, dynamically switching among different complexes and states, active versus inactive, bound versus unbound, immobile versus diffusive. This ability to switch dynamically between states is intimately connected to the ability of molecules to generate asymmetric patterns within cells. Focusing primarily on polarity pathways governed by the conserved PAR proteins, we discuss strategies enabled by these dynamic behaviors that are used by cells to polarize. We highlight not only how switching between states is linked to the ability of polarity proteins to localize asymmetrically, but also how cells take advantage of 'state switching' to regulate polarity in time and space.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Peglion F,Goehring NWdoi
10.1016/j.ceb.2019.05.002subject
Has Abstractpub_date
2019-10-01 00:00:00pages
121-130eissn
0955-0674issn
1879-0410pii
S0955-0674(19)30037-7journal_volume
60pub_type
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