Plasmalemmal caveolae and GPI-anchored membrane proteins.

abstract：:Hermansky-Pudlak syndrome defines a group of genetic disorders characterized by defects in organelles of the endosomal-lysosomal system, most notably melanosomes and platelet-dense granules. About a dozen genes have been implicated in the pathogenesis of the disease in humans and mice. Most of these genes encode novel...

journal_title：Current opinion in cell biology

authors： Dell'Angelica EC

更新日期：2004-08-01 00:00:00

abstract：:Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism...

journal_title：Current opinion in cell biology

authors： Anastasiadis PZ,Reynolds AB

更新日期：2001-10-01 00:00:00

abstract：:The cortical force-generating machinery pulls on dynamic plus-ends of astral microtubules to control spindle position and orientation, which underlie division type specification and cellular patterning in many eukaryotic cells. A prior work identified cytoplasmic dynein, a minus-end directed microtubule motor, as a ke...

journal_title：Current opinion in cell biology

authors： Kiyomitsu T

更新日期：2019-10-01 00:00:00

abstract：:Despite some recent setbacks, it remains clear that adult stem cells under appropriate experimental conditions can at some frequency exhibit a wider range of differentiation potentials than previously appreciated. This is underscored by the recent demonstration of the extensive differentiation potential of mesenchymal...

journal_title：Current opinion in cell biology

authors： Joshi CV,Enver T

更新日期：2002-12-01 00:00:00

abstract：:The Sec61 and SecYEG translocation channels mediate the selective transport of proteins across the endoplasmic reticulum and bacterial inner membrane, respectively. These channels are also responsible for the integration of membrane proteins. To accomplish these two critical events in protein expression, the transport...

journal_title：Current opinion in cell biology

authors： Mandon EC,Trueman SF,Gilmore R

更新日期：2009-08-01 00:00:00

abstract：:In the past year, major advances have been made in our understanding of the regulation of phosphoinositidase C, and of the action of the inositol trisphosphate receptor and how it may generate 'quantal' Ca2+ release. The functions of inositol tetrakisphosphate and of the 3-phosphorylated inositol lipids continue to ge...

journal_title：Current opinion in cell biology

authors： Irvine RF

更新日期：1992-04-01 00:00:00

abstract：:Cell competition is a short-range intercellular communication, in which cells compare their fitness with that of their neighbors and eliminate the cells with relatively lower fitness. It is considered important for the formation and maintenance of healthy tissues; however, its exact role during development, especially...

journal_title：Current opinion in cell biology

authors： Hashimoto M,Sasaki H

更新日期：2020-12-01 00:00:00

abstract：:The cerebral cortex is composed of hundreds of different types of neurons, which underlie its ability to perform highly complex neural processes. How cortical neurons are generated during development constitutes a major challenge in developmental neurosciences with important implications for brain repair and diseases....

journal_title：Current opinion in cell biology

authors： Tiberi L,Vanderhaeghen P,van den Ameele J

更新日期：2012-04-01 00:00:00

abstract：:Apoptosis, or programmed cell death, plays an essential role in specific cell deletion during normal embryonic and adult development in vertebrate and invertebrate species. Recent evidence suggests that signal transduction pathways governing cellular proliferation and cell cycle progression also mediate the physiologi...

journal_title：Current opinion in cell biology

authors： Lee S,Christakos S,Small MB

更新日期：1993-04-01 00:00:00

abstract：:The arrangement and dynamics of chromosomes inside the nucleus of mammalian cells have been studied intensively over the last two years. Although chromosomes are relatively immobile and occupy non-random positions in interphase, their dynamic movements in mitosis have traditionally been assumed to randomize this arran...

journal_title：Current opinion in cell biology

authors： Gerlich D,Ellenberg J

更新日期：2003-12-01 00:00:00

abstract：:The Polycomb group proteins are best known for their role as epigenetic regulators of the fly homeotic (Hox) gene clusters, but it has long been clear that these well conserved proteins have many other targets. For example, they are vital for maintaining both the pluripotency of stem cells and the identity of differen...

journal_title：Current opinion in cell biology

authors： Ringrose L

更新日期：2007-06-01 00:00:00

abstract：:Regulation of skeletal muscle determination and differentiation in vertebrates centers on a core regulatory network which is composed of two families of transcription factors, the MyoD group basic helix-loop-helix (bHLH) muscle regulatory factors (MRFs) and the myocyte enhancer factor 2 (MEF2) group of MADS-box regula...

journal_title：Current opinion in cell biology

authors： Yun K,Wold B

更新日期：1996-12-01 00:00:00

abstract：:Cellular asymmetries have been proposed to play a role in plant embryogenesis. Genetic studies of Arabidopsis and other experimental approaches in several plant species have addressed the origins of cellular asymmetry in specific cases. Although zygote polarity, which precedes the formation of the apical-basal axis of...

journal_title：Current opinion in cell biology

authors： Jürgens G,Grebe M,Steinmann T

更新日期：1997-12-01 00:00:00

abstract：:Organelles of the central membrane system of higher eukaryotes have been shown to utilize microtubules both for maintenance of their characteristic spatial distributions and for efficient transport of their protein and lipid to diverse sites within the cell. Recent work addressing the mechanisms that underlie this org...

journal_title：Current opinion in cell biology

authors： Cole NB,Lippincott-Schwartz J

更新日期：1995-02-01 00:00:00

abstract：:Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial cont...

journal_title：Current opinion in cell biology

authors： Harper CS,White AJ,Lackner LL

更新日期：2020-08-01 00:00:00

abstract：:The insulin receptor substrates function at the heart of the insulin signalling network. It has recently become apparent that the intracellular localisation of these molecules is regulated in a precise manner that is critical for both the generation and the termination of the insulin signal. Some insulin receptor subs...

journal_title：Current opinion in cell biology

authors： Whitehead JP,Clark SF,Urso B,James DE

更新日期：2000-04-01 00:00:00

abstract：:The cell biologist's insight into endosomal diversity, in terms of both form and function, has increased dramatically in the past few years. This understanding has been promoted by the availability of powerful new techniques that allow imaging of both cargo and machinery in the endocytic process in real time, and by o...

journal_title：Current opinion in cell biology

authors： Perret E,Lakkaraju A,Deborde S,Schreiner R,Rodriguez-Boulan E

更新日期：2005-08-01 00:00:00

abstract：:Recently, findings regarding a group of cancer predisposition and chromosome instability syndromes, Nijmegen breakage syndrome (NBS), the ataxia-telangiectasia-like disorder (A-TLD) and ataxia telangiectasia have shed light on the unexpected role of recombinational DNA repair proteins in DNA-damage-dependent cell-cycl...

journal_title：Current opinion in cell biology

authors： Petrini JH

更新日期：2000-06-01 00:00:00

abstract：:The activation of the serine/threonine kinase Raf-1 is proving to be an intricate multistep process. Recent advances in elucidating how Raf-1 becomes activated in response to signaling events have emphasized the role of phosphorylation and protein interactions in Raf-1 regulation. The picture clearly emerging is that ...

journal_title：Current opinion in cell biology

authors： Morrison DK,Cutler RE

更新日期：1997-04-01 00:00:00

abstract：:There are, in theory, several ways in which proteins may pass through the Golgi apparatus. Among these, the cisternal progression-maturation mode has gained broad consensus. However, there remain questions regarding the molecular mechanisms by which resident proteins are sorted from cargo and move backward to the prox...

journal_title：Current opinion in cell biology

authors： Nakano A,Luini A

更新日期：2010-08-01 00:00:00

abstract：:Oocyte cytoplasmic factors can reprogramme the sperm genome during fertilisation or the somatic cell genome during cloning. Diverse reprogramming machinery acts sequentially and interdependently on the imported genome to drive it to totipotency, but their three-dimensional interactions in the cytoplasm remain unknown....

journal_title：Current opinion in cell biology

authors： Kang YK,Lee KK,Han YM

更新日期：2003-06-01 00:00:00

abstract：:The past several years have seen major advances in our understanding of the mechanisms of microtubule destabilization by oncoprotein18/stathmin (Op18/stathmin) and related proteins. New structural information has clearly shown how members of the Op18/stathmin protein family bind tubulin dimers and suggests models for ...

journal_title：Current opinion in cell biology

authors： Cassimeris L

更新日期：2002-02-01 00:00:00

abstract：:The assembly of intermediate filament (IF) arrays involves the recruitment of a complex set of cell-type-specific IF-associated proteins. Some of them are integral membrane proteins, others act as crosslinking proteins with vectorial binding activities, and yet others comprise motor proteins. In vivo IFs appear to be ...

journal_title：Current opinion in cell biology

authors： Herrmann H,Aebi U

更新日期：2000-02-01 00:00:00

abstract：:Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail. The cilium is assembled from mature (mother) centr...

journal_title：Current opinion in cell biology

authors： Kim S,Dynlacht BD

更新日期：2013-08-01 00:00:00

abstract：:A major goal in cell biology is to understand the functional organization of macromolecular complexes in vivo. Electron microscopy is helping cell biologists to achieve this goal, thanks to its ability to resolve structural details in the nanometer range. While issues related to specimen preparation, imaging, and imag...

journal_title：Current opinion in cell biology

authors： Hoenger A,McIntosh JR

更新日期：2009-02-01 00:00:00

abstract：:The processes of dying are as tightly regulated as those of growth and proliferation, and together they establish a finely tuned balance that ensures proper organ size and function. Failure in the regulation of these responses lies at the heart of many human diseases. Certain members of the inhibitor of apoptosis (IAP...

journal_title：Current opinion in cell biology

authors： Lopez J,Meier P

更新日期：2010-12-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid and glucose homeostasis, inflammation and wound healing. In addition to ligand binding, phosphorylation can also regulate PPARs; the biological effects of phosphorylation depend on the stimulus, the kinase, the PPAR isotype, th...

journal_title：Current opinion in cell biology

authors： Gelman L,Michalik L,Desvergne B,Wahli W

更新日期：2005-04-01 00:00:00

abstract：:Golgins are a family of coiled-coil proteins associated with the Golgi apparatus necessary for tethering events in membrane fusion and as structural supports for Golgi cisternae. Recent work has shown that golgins such as GM130, golgin-45 and p115 bind to Rab GTPases via their coiled-coil domains, and that GM130, rath...

journal_title：Current opinion in cell biology

authors： Barr FA,Short B

更新日期：2003-08-01 00:00:00

abstract：:In the adult, angiogenesis, the formation of new blood vessels from pre-existing vasculature contributes to the pathogenesis of many disorders including cancer. The role of adhesion molecules, especially integrins, in pathological angiogenesis has long been the subject of investigation, mostly because of their potenti...

journal_title：Current opinion in cell biology

authors： Hodivala-Dilke K

更新日期：2008-10-01 00:00:00

abstract：:Peroxisomes are part of the ubiquitous set of eukaryotic organelles. They are small, single membrane bounded vesicles, specialized in the degradation of very-long-chain fatty acids and in synthesis of myelin lipids. Once considered inconspicuous, recent new insights in the formation and function of peroxisomes have re...

journal_title：Current opinion in cell biology

authors： van der Zand A,Tabak HF

更新日期：2013-08-01 00:00:00