Connexins: functions without junctions.

abstract：:A nuclear pore complex (NPC) is a large protein assembly that mediates the nucleocytoplasmic exchange of molecules. During the cell cycle, NPCs assemble, disassemble, and dynamically change their distribution on assembled nuclear envelope (NE), whereas in post-mitosis, NPCs are extremely stable. Extensive studies on i...

journal_title：Current opinion in cell biology

authors： Imamoto N,Funakoshi T

更新日期：2012-08-01 00:00:00

abstract：:Modulation of energy metabolism is emerging as a key aspect associated with cell fate transition. The establishment of a correct metabolic program is particularly relevant for neural cells given their high bioenergetic requirements. Accordingly, diseases of the nervous system commonly involve mitochondrial impairment....

journal_title：Current opinion in cell biology

authors： Lorenz C,Prigione A

更新日期：2017-12-01 00:00:00

abstract：:Recent discoveries have converged on the emerging enzymology that governs the G1-S phase transition of the mammalian somatic cell cycle. These discoveries have led to an appreciation of the regulatory role of proline-directed protein phosphorylation in molecular signalling, and have resulted in the identification of a...

journal_title：Current opinion in cell biology

authors： Hall FL,Vulliet PR

更新日期：1991-04-01 00:00:00

abstract：:How are cell morphogenesis and cell cycle coordinated? The fission yeast is a rod-shaped unicellular organism widely used to study how a cell self-organizes in space and time. Here, we discuss recent advances in understanding how the cell acquires and maintains its regular rod shape and uses it to control cell divisio...

journal_title：Current opinion in cell biology

authors： Hachet O,Bendezú FO,Martin SG

更新日期：2012-12-01 00:00:00

abstract：:Eukaryotic chromatin is a negatively charged polymer consisting of genomic DNA, histones, and various nonhistone proteins. Because of its highly charged character, the structure of chromatin varies greatly depending on the surrounding environment (i.e. cations etc.): from an extended 10-nm fiber, to a folded 30-nm fib...

journal_title：Current opinion in cell biology

authors： Maeshima K,Tamura S,Hansen JC,Itoh Y

更新日期：2020-06-01 00:00:00

abstract：:Protection from cancer and ensured longevity are tightly linked in mammals. One of the fundamental mechanisms contributing to both is the cellular response to DNA damage. The appropriate response is an initial attempt at repair, but if the damage is too extensive or compromises DNA metabolism, a signalling cascade tri...

journal_title：Current opinion in cell biology

authors： Mitchell JR,Hoeijmakers JH,Niedernhofer LJ

更新日期：2003-04-01 00:00:00

abstract：:Concomitant with packaging the genome, the cell nucleus must also spatially organize the nucleoplasm. This complex mixture of proteins and nucleic acids partitions into a variety of phase-separated, membraneless organelles called nuclear bodies. Significant progress has been made in understanding the relationship betw...

journal_title：Current opinion in cell biology

authors： Weber SC

更新日期：2017-06-01 00:00:00

abstract：:It has become clear that many vital metabolic circuits and early developmental programs are regulated translationally. Until recently, the mechanisms underlying most of these observations were poorly understood. The past year has witnessed several important advances in the understanding of how the translational appara...

journal_title：Current opinion in cell biology

authors： Hentze MW

更新日期：1995-06-01 00:00:00

abstract：:The shaping of the vertebrate embryonic body plan depends heavily on the narrowing and lengthening (convergence and extension) of embryonic tissues by cell intercalation, a process by which cells actively crawl between one another along the axis of convergence to produce a narrower, longer array. We discuss recent evi...

journal_title：Current opinion in cell biology

authors： Skoglund P,Keller R

更新日期：2010-10-01 00:00:00

abstract：:Positive-strand RNA (+RNA) viruses (e.g. poliovirus, hepatitis C virus, dengue virus, SARS-coronavirus) remodel cellular membranes to form so-called viral replication compartments (VRCs), which are the sites where viral RNA genome replication takes place. To induce VRC formation, these viruses extensively rewire lipid...

journal_title：Current opinion in cell biology

authors： Strating JR,van Kuppeveld FJ

更新日期：2017-08-01 00:00:00

abstract：:Cilia (and flagella) are microtubule-based protrusions that are found in single or multiple copies on the surface of most eukaryotic cells. Defects in cilia formation and/or function have now been correlated with an expanding spectrum of human genetic diseases termed ciliopathies. Recent work indicates that cilia are ...

journal_title：Current opinion in cell biology

authors： Verhey KJ,Yang W

更新日期：2016-08-01 00:00:00

abstract：:A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hier...

journal_title：Current opinion in cell biology

authors： Roskelley CD,Srebrow A,Bissell MJ

更新日期：1995-10-01 00:00:00

abstract：:The long-standing interest in centrioles and basal bodies stems from the evolutionary conservation of their structural design and from their dual mode of assembly (templated versus de novo), revealed by electron microscopic studies nearly four decades ago and unique for a subcellular organelle. Molecular dissection of...

journal_title：Current opinion in cell biology

authors： Beisson J,Wright M

更新日期：2003-02-01 00:00:00

abstract：:The nucleoskeleton is composed of many interacting structural proteins that provide the framework for DNA replication, transcription and a variety of other nuclear functions. For example, the type-V intermediate filament proteins, the lamins, and their associated proteins (e.g. Lap2alpha) play important roles in DNA r...

journal_title：Current opinion in cell biology

authors： Shumaker DK,Kuczmarski ER,Goldman RD

更新日期：2003-06-01 00:00:00

abstract：:This review discusses recent advances in our understanding of adhesion receptor trafficking in vitro, and extrapolates them as far as what is currently possible towards an understanding of migration in three dimensions in vivo. Our specific focus is the mechanisms for endocytosis and recycling of the two major classes...

journal_title：Current opinion in cell biology

authors： Jacquemet G,Humphries MJ,Caswell PT

更新日期：2013-10-01 00:00:00

abstract：:Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate from the interplay among ligands and receptors is greatly preserved. In this review we will cov...

journal_title：Current opinion in cell biology

authors： Bigas A,Espinosa L

更新日期：2018-12-01 00:00:00

abstract：:New techniques have enhanced our picture of E2F regulation. These studies have shed light on the roles played by individual E2F and retinoblastoma family members and implicate these proteins in processes extending well beyond the G1/S transition. One thorny issue remains: do our current molecular models of E2F and ret...

journal_title：Current opinion in cell biology

authors： Stevaux O,Dyson NJ

更新日期：2002-12-01 00:00:00

abstract：:One of the most notable trends in human evolution is the dramatic increase in brain size that has occurred in the great ape clade, culminating in humans. Of particular interest is the vast expanse of the cerebral cortex, which is believed to have resulted in our ability to perform higher cognitive functions. Recent in...

journal_title：Current opinion in cell biology

authors： Bond J,Woods CG

更新日期：2006-02-01 00:00:00

abstract：:Receptors for the two peroxisomal targeting signals PTS1 and PTS2 have recently been identified in yeasts. The disparate subcellular locations of PTS receptor homologs have led to proposals of receptor shuttling between the cytosol and the peroxisomal membrane, and to the suggestion that some of these molecules may ev...

journal_title：Current opinion in cell biology

authors： Subramani S

更新日期：1996-08-01 00:00:00

abstract：:Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and membranes. Innate immune cells and transformed cancer cells share the capacity for both constitutive and induced macropinocytosis, which...

journal_title：Current opinion in cell biology

authors： Stow JL,Hung Y,Wall AA

更新日期：2020-08-01 00:00:00

abstract：:During preimplantation development, the mouse embryo forms the blastocyst, which consists of a squamous epithelium enveloping a fluid-filled lumen and a cluster of pluripotent cells. The shaping of the blastocyst into its specific architecture is a prerequisite to implantation and further development of the embryo. Re...

journal_title：Current opinion in cell biology

authors： Özgüç Ö,Maître JL

更新日期：2020-10-01 00:00:00

abstract：:The mitotic spindle assembly and chromosome segregation in eukaryotes must be coordinated with the nuclear envelope (NE) remodeling. In a so-called 'open' mitosis the envelope of the mother nucleus is dismantled allowing the cytoplasmic spindle microtubules to capture the chromosomes. Alternatively, cells undergoing '...

journal_title：Current opinion in cell biology

authors： Zhang D,Oliferenko S

更新日期：2013-02-01 00:00:00

abstract：:Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate ...

journal_title：Current opinion in cell biology

authors： Garrod D,Chidgey M,North A

更新日期：1996-10-01 00:00:00

abstract：:The field of molecular physiology of ClC chloride channels has witnessed a tremendous surge in knowledge over the past few years; however, fundamental issues such as the stoichiometry of ClC channels and the identification of pore-lining sequences have only recently begun to be addressed. New studies have also provide...

journal_title：Current opinion in cell biology

authors： Valverde MA

更新日期：1999-08-01 00:00:00

abstract：:Telomeres, the natural termini of eukaryotic chromosomes, have been the subject of intense interest during the last decade because of the roles that these chromosome termini perform in both cancer and aging. As we become more cognizant of the consequences of telomere dysfunction on several aspects of human health, sig...

journal_title：Current opinion in cell biology

authors： Bertuch AA,Lundblad V

更新日期：2006-06-01 00:00:00

abstract：:Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic...

journal_title：Current opinion in cell biology

authors： Burke B

更新日期：2018-06-01 00:00:00

abstract：:Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals. During the past year, numerous candidate downstream targets for these GTPases have been identified using affinity chromatography and yeast two-hybrid t...

journal_title：Current opinion in cell biology

authors： Tapon N,Hall A

更新日期：1997-02-01 00:00:00

abstract：:It is during gastrulation that the primordial germ layers are specified, embryonic axes become morphologically manifest, and the embryonic body plan begins to take shape. As morphogenetic movements push and pull nascent tissues into position within the gastrula, new interactions are established between neighboring cel...

journal_title：Current opinion in cell biology

authors： Williams ML,Solnica-Krezel L

更新日期：2017-10-01 00:00:00

abstract：:Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functi...

journal_title：Current opinion in cell biology

authors： Will CL,Lührmann R

更新日期：1997-06-01 00:00:00

abstract：:At the time of this writing, searching Google Scholar for 'light-sheet microscopy' returns almost 8500 results; over three-quarters of which were published in the last 5 years alone. Searching for other advanced imaging methods in the last 5 years yields similar results: 'super-resolution microscopy' (>16 000), 'singl...

journal_title：Current opinion in cell biology

authors： Lemon WC,McDole K

更新日期：2020-10-01 00:00:00