Multiscale morphogenesis of the mouse blastocyst by actomyosin contractility.

Abstract:

:During preimplantation development, the mouse embryo forms the blastocyst, which consists of a squamous epithelium enveloping a fluid-filled lumen and a cluster of pluripotent cells. The shaping of the blastocyst into its specific architecture is a prerequisite to implantation and further development of the embryo. Recent studies identified the central role of the actomyosin cortex in generating the forces driving the successive steps of blastocyst morphogenesis. As seen in other developing animals, actomyosin functions across spatial scales from the subcellular to the tissue levels. In addition, the slow development of the mouse embryo reveals that actomyosin contractility operates at multiple timescales with periodic cortical waves of contraction every ∼80 s and tissue remodeling over hours.

journal_name

Curr Opin Cell Biol

authors

Özgüç Ö,Maître JL

doi

10.1016/j.ceb.2020.05.002

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

123-129

eissn

0955-0674

issn

1879-0410

pii

S0955-0674(20)30065-X

journal_volume

66

pub_type

杂志文章,评审
  • Viral transport and the cytoskeleton.

    abstract::In the past decade, studies into the way in which intracellular bacterial pathogens hijack and subvert their hosts have provided many important insights into regulation of the actin cytoskeleton and cell motility, in addition to increasing our understanding of the infection process. Viral pathogens, however, may ultim...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/s0955-0674(00)00180-0

    authors: Ploubidou A,Way M

    更新日期:2001-02-01 00:00:00

  • Spatial encoding of GPCR signaling in the nervous system.

    abstract::Several GPCRs, including receptors previously thought to signal primarily from the cell surface, have been recently shown to signal from many intracellular compartments. This raises the idea that signaling by any given receptor is spatially encoded in the cell, with distinct sites of signal origin dictating distinct d...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2018.12.006

    authors: Weinberg ZY,Crilly SE,Puthenveedu MA

    更新日期:2019-04-01 00:00:00

  • Adder and a coarse-grained approach to cell size homeostasis in bacteria.

    abstract::Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain their size without...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2016.02.004

    authors: Sauls JT,Li D,Jun S

    更新日期:2016-02-01 00:00:00

  • The dynamic spindle matrix.

    abstract::Chromosome segregation during mitosis is mediated by the mitotic spindle, a structure composed of microtubules associated with a variety of proteins. Additionally, a distinct biochemical milieu, the 'spindle matrix', has long been proposed to assist this process and recent work provided compelling evidence for its exi...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2014.01.002

    authors: Schweizer N,Weiss M,Maiato H

    更新日期:2014-06-01 00:00:00

  • Breaking down the wall: the nuclear envelope during mitosis.

    abstract::A defining feature of eukaryotic cells is the nucleus, which houses the genome inside the nuclear envelope (NE): a double lipid bilayer that separates the nuclear and cytoplasmic materials. Although the NE is commonly viewed as a barrier that is overcome only by embedded nuclear pore complexes (NPCs) that facilitate n...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2013.08.002

    authors: Smoyer CJ,Jaspersen SL

    更新日期:2014-02-01 00:00:00

  • Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation.

    abstract::Intracellular signals are received and generated by the alpha(IIb)beta(3) integrin on platelets. Recent advances have been made in the areas of agonist receptors that initiate platelet activation, downstream signaling molecules (e.g. small G-proteins and kinases) and changes in ligand-occupied alpha(IIb)beta(3) that c...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/s0955-0674(99)00018-6

    authors: Parise LV

    更新日期:1999-10-01 00:00:00

  • Targeting tumor cells.

    abstract::Several recent scientific and technical developments have made it possible to postulate the use of the 'magic bullet' concept; that is, the identification of specific antigens present on tumor cells that can be targeted either by therapeutic antibodies or by small molecules. The use of monoclonal antibodies in cancer,...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/s0955-0674(03)00106-6

    authors: Houshmand P,Zlotnik A

    更新日期:2003-10-01 00:00:00

  • Cadherin-actin interactions at adherens junctions.

    abstract::The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place th...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2011.07.001

    authors: Yonemura S

    更新日期:2011-10-01 00:00:00

  • Eukaryotic DNA replication control: lock and load, then fire.

    abstract::The initiation of chromosomal DNA replication involves initiator proteins that recruit and load hexameric DNA helicases at replication origins. This helicase loading step is tightly regulated in bacteria and eukaryotes. In contrast to the situation in bacteria, the eukaryotic helicase is loaded in an inactive form. Th...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2009.08.002

    authors: Remus D,Diffley JF

    更新日期:2009-12-01 00:00:00

  • Intermediate filaments and their associated proteins: multiple dynamic personalities.

    abstract::A fusion of mouse and human genetics has now proven that intermediate filaments form a flexible scaffold essential for structuring cytoplasm in a variety of cell contexts. In some cases, the formation of this scaffold is achieved through a newly identified family of intermediate-filament-associated proteins that form ...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/s0955-0674(98)80091-4

    authors: Houseweart MK,Cleveland DW

    更新日期:1998-02-01 00:00:00

  • Connexins: functions without junctions.

    abstract::Emerging studies indicate that connexins have activities completely unrelated to gap junctions and, conversely, that non-connexin proteins can form gap junction channels. ...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2004.07.014

    authors: Stout C,Goodenough DA,Paul DL

    更新日期:2004-10-01 00:00:00

  • Endosomal microdomains: Formation and function.

    abstract::It is widely recognized that after endocytosis, internalized cargo is delivered to endosomes that act as sorting stations. The limiting membrane of endosomes contain specialized subregions, or microdomains, that represent distinct functions of the endosome, including regions competing for cargo capture leading to degr...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2020.02.018

    authors: Norris A,Grant BD

    更新日期:2020-08-01 00:00:00

  • Changes in cell and tissue organization in cancer of the breast and colon.

    abstract::Most cancers arise in epithelia, the tissue type that lines all body cavities. The organization of epithelia enables them to act as a barrier and perform vectorial transport of molecules between body compartments. Crucial for their organization and function is a highly specialized network of cell adhesion and polarity...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2013.11.003

    authors: Hinck L,Näthke I

    更新日期:2014-02-01 00:00:00

  • Genetic control of branching morphogenesis during Drosophila tracheal development.

    abstract::Branching morphogenesis is a widely used strategy to increase the surface area of a given organ. A number of tissues undergo branching morphogenesis during development, including the lung, kidney, vascular system and numerous glands. Until recently, very little has been known about the genetic principles underlying th...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/s0955-0674(00)00160-5

    authors: Affolter M,Shilo BZ

    更新日期:2000-12-01 00:00:00

  • Transcription factors: positive and negative regulators of cell growth and disease.

    abstract::Recent advances in our understanding of transcription factors that regulate RNA polymerase II transcribed genes are described. This review considers the role of alternate protein-protein interactions to yield positive or negative regulation, the consequences of deregulated factor activity on cell function and approach...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/0955-0674(92)90015-5

    authors: Morimoto RI

    更新日期:1992-06-01 00:00:00

  • Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits.

    abstract::Metastatic cancer cells produce invasive membrane protrusions called invadopodia and pseudopodia, which play a central role in driving cancer cell dissemination in the body. Malignant cells use these structures to attach to and degrade extracellular matrix proteins, generate force for cell locomotion, and to penetrate...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2012.08.005

    authors: Klemke RL

    更新日期:2012-10-01 00:00:00

  • Design principles of tissue organisation: How single cells coordinate across scales.

    abstract::Cells act as building blocks of multicellular organisms, forming higher-order structures at different biological scales. Niches, tissues and, ultimately, entire organisms consist of single cells that remain in constant communication. Emergence of developmental patterns and tissue architecture thus relies on single cel...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2020.07.004

    authors: Zinner M,Lukonin I,Liberali P

    更新日期:2020-12-01 00:00:00

  • Prespecification and plasticity: shifting mechanisms of cell migration.

    abstract::Cell migration is a universal process involving different morphologies and mechanisms in different cell types and tissue environments. Prespecified cell-type-specific patterns of cell migration can be classified into single cell migration (amoeboid, mesenchymal) and collective migration modes (cell sheets, strands, tu...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2003.11.001

    authors: Friedl P

    更新日期:2004-02-01 00:00:00

  • Basal body/centriole assembly and continuity.

    abstract::The long-standing interest in centrioles and basal bodies stems from the evolutionary conservation of their structural design and from their dual mode of assembly (templated versus de novo), revealed by electron microscopic studies nearly four decades ago and unique for a subcellular organelle. Molecular dissection of...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/s0955-0674(02)00017-0

    authors: Beisson J,Wright M

    更新日期:2003-02-01 00:00:00

  • Desmosomes: differentiation, development, dynamics and disease.

    abstract::Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate ...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/s0955-0674(96)80108-6

    authors: Garrod D,Chidgey M,North A

    更新日期:1996-10-01 00:00:00

  • Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives.

    abstract::Cell polarization is critical for lineage segregation and morphogenesis during mammalian embryogenesis. However, the processes and mechanisms that establish cell polarity in the mammalian embryo are not well understood. Recent studies suggest that unique regulatory mechanisms are deployed by the mouse embryo to establ...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2019.11.005

    authors: Zhu M,Zernicka-Goetz M

    更新日期:2020-02-01 00:00:00

  • Functions of gelsolin: motility, signaling, apoptosis, cancer.

    abstract::Several new members of the gelsolin family have been discovered in the past year. Determination of the structure of gelsolin and identification of lysophosphatidic acid as a negative regulator provide novel functional insights. Gelsolin is an obligate downstream effector of Rac for motility in dermal fibroblasts, regu...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/s0955-0674(99)80012-x

    authors: Kwiatkowski DJ

    更新日期:1999-02-01 00:00:00

  • Cell cycle markers in clinical oncology.

    abstract::Analysis of complex and redundant pathways that control proliferation, differentiation, apoptosis and DNA damage response by global genome wide analysis is an intensive area of investigation aimed at identifying unique molecular signatures of prognostic significance in cancer. An alternative approach is to focus on th...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2007.10.005

    authors: Williams GH,Stoeber K

    更新日期:2007-12-01 00:00:00

  • Cytoskeletal crosstalk: when three different personalities team up.

    abstract::Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal networks, made of actin filaments, microtubules, and intermediate filaments. These three types of cytoskeletal polymers have rather different structural and physical properties, enabling specific cellular functions. However, there ...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2014.10.005

    authors: Huber F,Boire A,López MP,Koenderink GH

    更新日期:2015-02-01 00:00:00

  • Wnt signaling: implications in endoderm development and pancreas organogenesis.

    abstract::The pancreas is derived from the foregut endoderm during embryonic development. After gastrulation and endoderm germ layer formation complex morphogenetic events coupled with cell differentiation programs pattern the gut tube and induce pancreas organogenesis. This results in formation of exocrine, ductal and hormone-...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2019.07.002

    authors: Scheibner K,Bakhti M,Bastidas-Ponce A,Lickert H

    更新日期:2019-12-01 00:00:00

  • Towards molecular mechanisms for gamete adhesion and fusion during mammalian fertilization.

    abstract::The process of fertilization is fundamental to the maintenance of life. The ability of unfertilized eggs and free-swimming sperm to recognize, adhere to, and fuse with each other are vital aspects of the fertilization process. Significant progress has been made recently in identifying and characterizing (glyco)protein...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/0955-0674(95)80107-3

    authors: Wassarman PM

    更新日期:1995-10-01 00:00:00

  • Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs.

    abstract::The control of translation and mRNA degradation plays a key role in the regulation of eukaryotic gene expression. In the cytosol, mRNAs engaged in translation are distributed throughout the cytosol, while translationally inactive mRNAs can accumulate in P bodies, in complex with mRNA degradation and translation repres...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2009.03.005

    authors: Balagopal V,Parker R

    更新日期:2009-06-01 00:00:00

  • Regulation of intracellular membrane transport.

    abstract::A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/0955-0674(92)90077-p

    authors: Gruenberg J,Clague MJ

    更新日期:1992-08-01 00:00:00

  • Probing the macromolecular organization of cells by electron tomography.

    abstract::A major goal in cell biology is to understand the functional organization of macromolecular complexes in vivo. Electron microscopy is helping cell biologists to achieve this goal, thanks to its ability to resolve structural details in the nanometer range. While issues related to specimen preparation, imaging, and imag...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2008.12.003

    authors: Hoenger A,McIntosh JR

    更新日期:2009-02-01 00:00:00

  • Chromatin and signaling.

    abstract::Signaling involves the coordinated action of multiple molecules including stimuli, receptors and enzymes part of which interact with the transcriptional machinery and target chromatin. Signaling systems regulate the cell events responsible for survival, development and homeostasis. Many of the signaling pathways induc...

    journal_title:Current opinion in cell biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ceb.2013.02.016

    authors: Suganuma T,Workman JL

    更新日期:2013-06-01 00:00:00