Abstract:
:During preimplantation development, the mouse embryo forms the blastocyst, which consists of a squamous epithelium enveloping a fluid-filled lumen and a cluster of pluripotent cells. The shaping of the blastocyst into its specific architecture is a prerequisite to implantation and further development of the embryo. Recent studies identified the central role of the actomyosin cortex in generating the forces driving the successive steps of blastocyst morphogenesis. As seen in other developing animals, actomyosin functions across spatial scales from the subcellular to the tissue levels. In addition, the slow development of the mouse embryo reveals that actomyosin contractility operates at multiple timescales with periodic cortical waves of contraction every ∼80 s and tissue remodeling over hours.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Özgüç Ö,Maître JLdoi
10.1016/j.ceb.2020.05.002subject
Has Abstractpub_date
2020-10-01 00:00:00pages
123-129eissn
0955-0674issn
1879-0410pii
S0955-0674(20)30065-Xjournal_volume
66pub_type
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