Abstract：
:The pancreas is derived from the foregut endoderm during embryonic development. After gastrulation and endoderm germ layer formation complex morphogenetic events coupled with cell differentiation programs pattern the gut tube and induce pancreas organogenesis. This results in formation of exocrine, ductal and hormone-producing endocrine cells. Among these, endocrine cells are responsible for blood glucose homeostasis and their malfunction leads to diabetes mellitus, which cannot be stopped or reversed by the current standard treatments. Thus, intense efforts to regenerate or replace the lost or dysfunctional insulin-producing β-cells are on the way. This depends on identifying the factors that coordinate pancreas organogenesis. Here, we highlight the contribution of canonical and non-canonical Wnt signaling branches in orchestrating endoderm formation, pancreatic morphogenesis as well as endocrine cell formation and function.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Scheibner K,Bakhti M,Bastidas-Ponce A,Lickert Hdoi
10.1016/j.ceb.2019.07.002subject
Has Abstractpub_date
2019-12-01 00:00:00pages
48-55eissn
0955-0674issn
1879-0410pii
S0955-0674(19)30012-2journal_volume
61pub_type
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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journal_title：Current opinion in cell biology
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