Unconventional protein secretion (UPS) pathways in plants.

abstract：:Directional guidance of migrating cells is relatively well explored in the reductionist setting of cell culture experiments. Here spatial gradients of chemical cues as well as gradients of mechanical substrate characteristics prove sufficient to attract single cells as well as their collectives. How such gradients pre...

journal_title：Current opinion in cell biology

authors： Majumdar R,Sixt M,Parent CA

更新日期：2014-10-01 00:00:00

abstract：:The assembly of intermediate filament (IF) arrays involves the recruitment of a complex set of cell-type-specific IF-associated proteins. Some of them are integral membrane proteins, others act as crosslinking proteins with vectorial binding activities, and yet others comprise motor proteins. In vivo IFs appear to be ...

journal_title：Current opinion in cell biology

authors： Herrmann H,Aebi U

更新日期：2000-02-01 00:00:00

abstract：:Evolution of the mammalian sex chromosomes heavily impacts on the expression of X-encoded genes, both in marsupials and placental mammals. The loss of genes from the Y chromosome forced a two-fold upregulation of dose sensitive X-linked homologues. As a corollary, female cells would experience a lethal dose of X-linke...

journal_title：Current opinion in cell biology

authors： Gribnau J,Grootegoed JA

更新日期：2012-06-01 00:00:00

abstract：:Cells act as building blocks of multicellular organisms, forming higher-order structures at different biological scales. Niches, tissues and, ultimately, entire organisms consist of single cells that remain in constant communication. Emergence of developmental patterns and tissue architecture thus relies on single cel...

journal_title：Current opinion in cell biology

authors： Zinner M,Lukonin I,Liberali P

更新日期：2020-12-01 00:00:00

abstract：:Recent discoveries have converged on the emerging enzymology that governs the G1-S phase transition of the mammalian somatic cell cycle. These discoveries have led to an appreciation of the regulatory role of proline-directed protein phosphorylation in molecular signalling, and have resulted in the identification of a...

journal_title：Current opinion in cell biology

authors： Hall FL,Vulliet PR

更新日期：1991-04-01 00:00:00

abstract：:The septins are a novel family of proteins that were first recognized in yeast as proteins associated with the neck filaments. Recent work has shown that septins are also present in other fungi, insects, and vertebrates. Despite the apparent differences in modes of cytokinesis amongst species, septins appear to be ess...

journal_title：Current opinion in cell biology

authors： Longtine MS,DeMarini DJ,Valencik ML,Al-Awar OS,Fares H,De Virgilio C,Pringle JR

更新日期：1996-02-01 00:00:00

abstract：:Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy bala...

journal_title：Current opinion in cell biology

authors： Wu Z,Puigserver P,Spiegelman BM

更新日期：1999-12-01 00:00:00

abstract：:Classical heterochromatin chromosomal landmarks, such as centromeres and telomeres, are characterized by specific chromatin signatures. Among these, the incorporation of histone variants has recently emerged as an important feature. Using the centromere as a paradigm, we consider the role of histone variant dynamics i...

journal_title：Current opinion in cell biology

authors： Boyarchuk E,Montes de Oca R,Almouzni G

更新日期：2011-06-01 00:00:00

abstract：:Inter-organelle membrane contact sites are zones where heterologous membranes, usually the endoplasmic reticulum plus a partner organelle, come into close apposition. These sites are very poorly understood because so few of their components have been identified; however, it is clear that they are specialised for traff...

journal_title：Current opinion in cell biology

authors： Levine T,Loewen C

更新日期：2006-08-01 00:00:00

abstract：:The advent of green fluorescent protein technology, its use in photobleaching experiments and the development of methods to rapidly acquire images and analyze complex datasets have opened the door to unraveling the mechanisms of nuclear functions in living cells. Studies over the past few years have characterized the ...

journal_title：Current opinion in cell biology

authors： Janicki SM,Spector DL

更新日期：2003-04-01 00:00:00

abstract：:The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depe...

journal_title：Current opinion in cell biology

authors： Doyle AD,Petrie RJ,Kutys ML,Yamada KM

更新日期：2013-10-01 00:00:00

abstract：:Vesicle and tubule transport containers move proteins and lipids from one membrane system to another. Newly forming transport containers frequently have electron-dense coats. Coats coordinate the accumulation of cargo and sculpt the membrane. Recent advances have shown that components of both COP1 and clathrin-adaptor...

journal_title：Current opinion in cell biology

authors： McMahon HT,Mills IG

更新日期：2004-08-01 00:00:00

abstract：:To preserve fitness in unpredictable, fluctuating environments, a range of biological systems probabilistically generate variant phenotypes--a process often referred to as 'bet-hedging', after the financial practice of diversifying assets to minimize risk in volatile markets. The molecular mechanisms enabling bet-hedg...

journal_title：Current opinion in cell biology

authors： Weinberger LS

更新日期：2015-12-01 00:00:00

abstract：:Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis fo...

journal_title：Current opinion in cell biology

authors： Griffith JK,Baker ME,Rouch DA,Page MG,Skurray RA,Paulsen IT,Chater KF,Baldwin SA,Henderson PJ

更新日期：1992-08-01 00:00:00

abstract：:Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold o...

journal_title：Current opinion in cell biology

authors： Fernandez-Martinez J,Rout MP

更新日期：2009-08-01 00:00:00

abstract：:There is a growing appreciation that metabolic signals are integrated and coupled to cell cycle progression. However, the molecular wiring that connects nutrient availability, biosynthetic intermediates and energetic balance to the core cell cycle machinery remains incompletely understood. In this review, we explore t...

journal_title：Current opinion in cell biology

authors： Lee IH,Finkel T

更新日期：2013-12-01 00:00:00

abstract：:Research over the past two decades has defined a window of time in the early/mid G1 phase of the cell cycle during which mammalian cells are responsive to extracellular signals. Recent evidence indicates that this period ends with the phosphorylation of the retinoblastoma protein, enabling the cells to pass through th...

journal_title：Current opinion in cell biology

authors： Planas-Silva MD,Weinberg RA

更新日期：1997-12-01 00:00:00

abstract：:The principal subunits of a large superfamily of plasma-membrane cation channels are functionally autonomous in ion conductance and in gating by membrane potential and intracellular ligands. Recent work has located the structural elements responsible for the ion conductance and gating of these channels. These studies ...

journal_title：Current opinion in cell biology

authors： Catterall WA

更新日期：1994-08-01 00:00:00

abstract：:Integrins are heterodimeric transmembrane receptors that connect the extracellular matrix environment to the actin cytoskeleton via adaptor molecules through assembly of a range of adhesion structures. Recent advances in biochemical, imaging and biophysical methods have enabled a deeper understanding of integrin signa...

journal_title：Current opinion in cell biology

authors： Michael M,Parsons M

更新日期：2020-04-01 00:00:00

abstract：:Force arising from actin polymerization and myosin activity drives a number of different actin-based cell movements. Several new reports support previous data suggesting that actin polymerization drives lamellipodial protrusion and bacterial propulsion, and one report describes a more indirect role for actin assembly ...

journal_title：Current opinion in cell biology

authors： Cramer LP,Mitchison TJ,Theriot JA

更新日期：1994-02-01 00:00:00

abstract：:Studies of yeast transcription factors have contributed greatly to understanding basic molecular mechanisms of eukaryotic gene regulation, largely due to powerful genetic approaches that are unavailable in other organisms. The broad outlines of these mechanisms are fairly well understood, and there is an increasing nu...

journal_title：Current opinion in cell biology

authors： Struhl K

更新日期：1993-06-01 00:00:00

abstract：:The recent introduction of positional proteomics made it possible to screen for protease processing events on a proteome-wide scale. As a highly regulated and protease-dependent process, cell death has been particularly well-studied with these emerging technologies. This review provides an overview of the results obta...

journal_title：Current opinion in cell biology

authors： Impens F,Vandekerckhove J,Gevaert K

更新日期：2010-12-01 00:00:00

abstract：:The establishment of left-right asymmetry during development of vertebrate embryos depends on leftward flow in the nodal cavity. The flow is produced by the rotational movement of the posteriorly tilted nodal cilia. However, it remains poorly understood how the nodal cilia are tilted posteriorly, and how the direction...

journal_title：Current opinion in cell biology

authors： Hirokawa N,Tanaka Y,Okada Y

更新日期：2012-02-01 00:00:00

abstract：:Myosins are a large family of structurally diverse mechanoenzymes which, upon interaction with actin filaments, convert energy from ATP hydrolysis into mechanical force. Consistent with the ubiquitous association of actin with membranes, many of these novel myosins are membrane-associated. In the past two years, evide...

journal_title：Current opinion in cell biology

authors： Hasson T,Mooseker MS

更新日期：1995-08-01 00:00:00

abstract：:Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the...

journal_title：Current opinion in cell biology

authors： Nicchitta CV

更新日期：2002-08-01 00:00:00

abstract：:A fusion of mouse and human genetics has now proven that intermediate filaments form a flexible scaffold essential for structuring cytoplasm in a variety of cell contexts. In some cases, the formation of this scaffold is achieved through a newly identified family of intermediate-filament-associated proteins that form ...

journal_title：Current opinion in cell biology

authors： Houseweart MK,Cleveland DW

更新日期：1998-02-01 00:00:00

abstract：:The structure of mitochondria is highly dynamic. Mitochondrial shape is cell-type specific and can be modified to meet changing requirements in energy production, calcium homeostasis, lipid biogenesis, fatty acid synthesis and other mitochondrial activities. This is achieved by modulating the dynamic properties of mit...

journal_title：Current opinion in cell biology

authors： Hoppins S

更新日期：2014-08-01 00:00:00

abstract：:A major current issue in vesicle trafficking is whether NSF (N-ethylmaleimide-sensitive factor) and alpha-SNAP (alpha-soluble NSF attachment protein) are required prior to SNARE (SNAP receptor) complex formation to allow vesicle docking, or after docking at a step close to membrane fusion. Recent studies of yeast vacu...

journal_title：Current opinion in cell biology

authors： Hay JC,Scheller RH

更新日期：1997-08-01 00:00:00

abstract：:Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism...

journal_title：Current opinion in cell biology

authors： Anastasiadis PZ,Reynolds AB

更新日期：2001-10-01 00:00:00

abstract：:Recent advances in several key areas of fibronectin biology are discussed. These include its expression, from transcription to secretion of dimers, the structural requirements for several of the binding activities, potential roles for alternatively spliced segments in cell adhesion, and the assembly of a fibronectin m...

journal_title：Current opinion in cell biology

authors： Schwarzbauer JE

更新日期：1991-10-01 00:00:00