Abstract:
:Centrioles are essential microtubule-based organelles, typically present in pairs, which organize cilia and centrosomes. Their mode of biogenesis is unique for a subcellular organelle since, during cell division, each pre-existing centriole guides the formation of a new one, a process that is coordinated with DNA replication. After centriole duplication, the new centrosomes migrate in opposite direction and localize at each pole of the mitotic spindle. This singular dynamics led to think that centrioles were permanent self-replicating structures coordinating cytoplasm and nuclear division. This vision then fell gradually into disuse when centrioles were shown to be capable to form de novo, in the absence of a pre-existing structure, and to be actually dispensable for cell division. However, new data, which are reviewed here, have breathed new life into the old ideas.
journal_name
Curr Opin Cell Bioljournal_title
Current opinion in cell biologyauthors
Meunier A,Spassky Ndoi
10.1016/j.ceb.2016.02.007subject
Has Abstractpub_date
2016-02-01 00:00:00pages
60-7eissn
0955-0674issn
1879-0410pii
S0955-0674(16)30014-Xjournal_volume
38pub_type
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